UniProtKB - Q856K7 (KU_BPMCO)
Protein
Protein Ku
Gene
87
Organism
Mycobacterium phage Corndog (Mycobacteriophage Corndog)
Status
Functioni
Required for replication of viruses with short cos ends (4 bases). Stimulates dsDNA end-joining by host LigD. Binds dsDNA with either blunt, 5'- or 3-overhangs, protecting it from host exonuclease degradation.1 Publication
GO - Molecular functioni
- double-stranded DNA binding Source: UniProtKB
GO - Biological processi
- DNA end degradation evasion by virus Source: UniProtKB-KW
- double-strand break repair via nonhomologous end joining Source: InterPro
- viral entry into host cell Source: UniProtKB-KW
- viral genome circularization Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | DNA end degradation evasion by virus, Host-virus interaction, Viral genome circularization, Virus entry into host cell |
Names & Taxonomyi
Protein namesi | Recommended name: Protein KuAlternative name(s): Cd-Ku Gp87 |
Gene namesi | Name:87 |
Organismi | Mycobacterium phage Corndog (Mycobacteriophage Corndog) |
Taxonomic identifieri | 205875 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Uroviricota › Caudoviricetes › Caudovirales › Siphoviridae › Corndogvirus |
Virus hosti | Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) [TaxID: 246196] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000425947 | 1 – 284 | Protein KuAdd BLAST | 284 |
Interactioni
Subunit structurei
Homodimer (Probable).
Interacts with host LigD.
Curated1 PublicationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 189 | KuAdd BLAST | 180 |
Family and domain databases
Gene3Di | 2.40.290.10, 1 hit |
InterProi | View protein in InterPro IPR006164, Ku70/Ku80_beta-barrel_dom IPR009187, Prok_Ku IPR016194, SPOC-like_C_dom_sf |
PANTHERi | PTHR41251, PTHR41251, 1 hit |
Pfami | View protein in Pfam PF02735, Ku, 1 hit |
PIRSFi | PIRSF006493, Prok_Ku, 1 hit |
SMARTi | View protein in SMART SM00559, Ku78, 1 hit |
SUPFAMi | SSF100939, SSF100939, 1 hit |
i Sequence
Sequence statusi: Complete.
Q856K7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRSVGNVDLT IGLVTVPVKM VGVSESHDRK ASMYHPHEDG NFGKIKMPKL
60 70 80 90 100
CEDCGEVVPT ADIAKGFEEG GDIVILTADE LASIAAATGA ALEVPQFVKA
110 120 130 140 150
EQINPMLFAN ENIYRLVPDP KRGRQAATTY LMVRHILVSQ ELVGVVQYTR
160 170 180 190 200
WGRNRLGVLD VEPSDDGGVL VIRNMMWADE LRSTEGIVPT NVTEDDIDPR
210 220 230 240 250
LLPVMASVVE SMTGDWDPTA YTDRYTEQLS EAITAKAQGD EIATVASESG
260 270 280
KAIDDVSDLL AKLEASIQKK APAKKATARR KKTA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY129335 Genomic DNA Translation: AAN02019.1 |
RefSeqi | NP_817938.1, NC_004685.1 |
Genome annotation databases
GeneIDi | 1259566 |
KEGGi | vg:1259566 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY129335 Genomic DNA Translation: AAN02019.1 |
RefSeqi | NP_817938.1, NC_004685.1 |
3D structure databases
SMRi | Q856K7 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 1259566 |
KEGGi | vg:1259566 |
Family and domain databases
Gene3Di | 2.40.290.10, 1 hit |
InterProi | View protein in InterPro IPR006164, Ku70/Ku80_beta-barrel_dom IPR009187, Prok_Ku IPR016194, SPOC-like_C_dom_sf |
PANTHERi | PTHR41251, PTHR41251, 1 hit |
Pfami | View protein in Pfam PF02735, Ku, 1 hit |
PIRSFi | PIRSF006493, Prok_Ku, 1 hit |
SMARTi | View protein in SMART SM00559, Ku78, 1 hit |
SUPFAMi | SSF100939, SSF100939, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KU_BPMCO | |
Accessioni | Q856K7Primary (citable) accession number: Q856K7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 19, 2014 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |