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Entry version 81 (05 Jun 2019)
Sequence version 1 (01 Nov 1996)
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Protein

RNA-dependent RNA polymerase

Gene

pc1

Organism
Rice stripe virus (isolate T) (RSV)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandNucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-dependent RNA polymerase (EC:2.7.7.48)
Alternative name(s):
Replicase
Transcriptase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:pc1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRice stripe virus (isolate T) (RSV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36394 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaNegarnaviricotaPolyploviricotinaEllioviricetesBunyaviralesPhenuiviridaeTenuivirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiAvena sativa (Oat) [TaxID: 4498]
Digitaria [TaxID: 66017]
Eragrostis [TaxID: 38413]
Hordeum vulgare (Barley) [TaxID: 4513]
Oryza sativa (Rice) [TaxID: 4530]
Setaria italica (Foxtail millet) (Panicum italicum) [TaxID: 4555]
Setaria viridis (Green bristlegrass) (Setaria italica subsp. viridis) [TaxID: 4556]
Triticum aestivum (Wheat) [TaxID: 4565]
Zea mays (Maize) [TaxID: 4577]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006677 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004039291 – 2919RNA-dependent RNA polymeraseAdd BLAST2919

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q85431

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q85431

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1472 – 1671RdRp catalyticPROSITE-ProRule annotationAdd BLAST200

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022531 DUF3770
IPR029124 L_protein_N
IPR003323 OTU_dom
IPR007099 RNA-dir_pol_NSvirus
IPR015842 RNA-dir_pol_tenuivirus
IPR007322 RNA_pol_bunyavir

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04196 Bunya_RdRp, 1 hit
PF12603 DUF3770, 1 hit
PF15518 L_protein_N, 1 hit
PF02338 OTU, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036873 L_TenuV, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50802 OTU, 1 hit
PS50525 RDRP_SSRNA_NEG_SEG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q85431-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTPPLVIPL HVHGRSYELL AGYHEVDWQE IEELEETDVR GDGFCLYHSI
60 70 80 90 100
LYSMGLSKEN SRTTEFMIKL RSNPAICQLD QEMQLSLMKQ LDPNDSSAWG
110 120 130 140 150
EDIAIGFIAI ILRIKIIAYQ TVDGKLFKTI YGAEFESTIR IRNYGNYHFK
160 170 180 190 200
SLETDFDHKV KLRSKIEEFL RMPVEDCESI SLWHASVYKP IVSDSLSGHK
210 220 230 240 250
SFSNVDELIG SIISSMYKIM DNGDQCFLWS AMRMVARPSE KLYALAVFLG
260 270 280 290 300
FNLKFYHVRK RAEKLTAKLE SDHTNLGVKL IEVYEVSEPT RSTWVLKPGG
310 320 330 340 350
SRITETRNFV IEEIIDNRRS LESLFVSSSE YPAELCSQKL SAIKDRIALM
360 370 380 390 400
FGFINRTPEN SGRELYINTY YLKRILQVER NVIRDSLRSQ PAVGMIQIIR
410 420 430 440 450
LPTAFGTYNP EVGTLLLAQT GLIYRLGTTT RVQMEVRRSP SVISRSHKIT
460 470 480 490 500
SFPETQKHNN NLYDYAPRTQ ETFYHPNAEI YEAVDVKTPS VITEIVDNHI
510 520 530 540 550
VIKLNTDDKG WSVSDSIKQD FVYRKRLMDA KNIVHDFVFD ILSTETDKSF
560 570 580 590 600
KGADLSIGGI SDNWSPDVII SRESDPQYED IVVYEFTTRS TESIESLLRS
610 620 630 640 650
VEVKSLRYKE AIQERAITLK KRISYYTICV SLDAVATNLL SLPADVCREL
660 670 680 690 700
IIRLRVANQV KIQLADNDIN LDSATLLAPD IYRIKEMFRE SFPNNKFIHP
710 720 730 740 750
ITKEMYEHFV NPMISGEKDY VANLKSIIDK ETRDEQRKNL ESLKVVDGKK
760 770 780 790 800
YTERKAETAL NEMSQAEEHY RSYFENDNFR STLKAPVQLP LIIPDVSSQD
810 820 830 840 850
NQFSNKELSD RIRKKPIDHP IYNIWDQAVN KRNCSIALGH LDELEISMLE
860 870 880 890 900
GQVAKKVEES YKKDRSQYNR TTLLTNMKED IYLAERGINA KKRLEEPDVK
910 920 930 940 950
FYRDQSKRPF HPFVSETRDI EQFTQKECLE LNEESGHCSL INVEDLVLSA
960 970 980 990 1000
LELHEVGDLE HLWNNIKAHS KTKFALYAKF ISDLATELAI SLSQNCKEDT
1010 1020 1030 1040 1050
YVVKKLRDFS CYVLIKPVNL KSNVFFSLYI PSNIYKSHNT TFKTLIGSPE
1060 1070 1080 1090 1100
SGYMTDFVSA NVSKLVNWVR CEAMMLAQRG FWREFYAVAP SIEEQDGMAE
1110 1120 1130 1140 1150
PDSVCQMMSW TLLILLNDKH QLEEMITVSR FVHMEGFVTF PAWPKPYKMF
1160 1170 1180 1190 1200
DKLSVTPRSR LECLVIKRLI MLMKHYSENP IKFMIEDEKK KWFGFKNMFL
1210 1220 1230 1240 1250
LDCNGKLADL SDQDQMLNLF YLGYLKNKDE EVEDNGMGQL LTKILGFESA
1260 1270 1280 1290 1300
MPKTRDFLGM KDPEYGTIKK HEFSISYVKD LCDKFLDRLK KTHGIKDPIT
1310 1320 1330 1340 1350
YLGDKIAKFL STQFIETMAS LKASSNFSED YYLYTPSRRL KNQEQSRSKH
1360 1370 1380 1390 1400
VIDAGGNISA SVKGKLYHRS KVIEKLTTLI KDETPGKELK IVVDLLPKAM
1410 1420 1430 1440 1450
EVLNKNECMH ICIFKKNQHG GLREIYVLNI FERIMQKTVE DFSRAILECC
1460 1470 1480 1490 1500
PSETMTSPKN KFRIPELHNM EARKTLKNEY MTISTSDDAS KWNQGHYVSK
1510 1520 1530 1540 1550
FMCMLLRLTP TYYHGFLVQA LQLWHHKKIF LGDQLLQLFN QNAMLNTMDT
1560 1570 1580 1590 1600
TLMKVFQAYK GEIQVPWMKA GRSYIETETG MMQGILHYTS SLFHAIFLDQ
1610 1620 1630 1640 1650
LAEECRRDIN RAIKTINNKE NEKVSCIVNN MESSDDSSFI ISIPNFKENE
1660 1670 1680 1690 1700
AAQLYLLCVV NSWFRKKEKL GTYLGIYKSP KSTTQTLFVM EFNSEFFFSG
1710 1720 1730 1740 1750
DVHRPTFRWV NAAVLIGEQE TLSGIQEELS NTLKDVIEGG GTYALTFIVQ
1760 1770 1780 1790 1800
VAQAMIHYRM LGSSASSVWP AYETLLKNSY DPALGFFLMD NPKCAGLLGF
1810 1820 1830 1840 1850
NYNVWIACTT TPLGEKYHEM IQEEMKAESQ SLKSVTEDTI NTGLVSRTTM
1860 1870 1880 1890 1900
VGFGNKKRWM KLMTTLNLSA DVYEKIEEEP RVYFFHAATA EQIIQKIAIK
1910 1920 1930 1940 1950
MKSPGVIQSL SKGNMLARKI ASSVFFISRH IVFTMSAYYD ADPETRKTSL
1960 1970 1980 1990 2000
LKELINSSKI PQRHDYLQEP HTLKPTKVEV DEDSWEFKSA KEECVRVLKQ
2010 2020 2030 2040 2050
RIKIHTGREE RSISLLFENM AKSMIGRCTD QYDVRENVSI LACALKMNYS
2060 2070 2080 2090 2100
IFKKDAAPNR YLLDEKNLVY PLIGKEVSVY VKSDKVHIEI SEKKERLSTK
2110 2120 2130 2140 2150
LFNIDKMKDI EETLSLLFPS YGDYLSLKET IDQVTFQSAI HKVNERRRVR
2160 2170 2180 2190 2200
ADVHLTGTEG FSKLPMYTAA VWAWFDVKTI PAHDSIYRTI WKVYKEQYSW
2210 2220 2230 2240 2250
LSDTLKETVE KGPFKTVQGV VNFISRAGVR SRVVHLVGSF GKNVRGSINL
2260 2270 2280 2290 2300
VTAIKDNFSN GLVFKGNIFD IKAKKTRESL DNYLSICTTL SQAPITKHDK
2310 2320 2330 2340 2350
NQILRSLFVS GPRIQYVSSQ FGSRRNRMSI LQEVVADDPT LHWPDQDTSQ
2360 2370 2380 2390 2400
KQLEDKFREL AHKELPFLTE KVFHDYLEKI EQLMKENTHL GGRDVDASKT
2410 2420 2430 2440 2450
PYVLARANDI EIHCYELWRE YDEDEDEAYQ AYCSEVEAAM DQEKLNALIE
2460 2470 2480 2490 2500
RYHVDPKANW IQMLMNGEIE TVEELNKLDK GFESHRLALV ERIRVGKLGI
2510 2520 2530 2540 2550
LGSYTKCQQR IEELDGEGNK THRYTGEGIW RGSFDDSDVC IVVQDLKKTR
2560 2570 2580 2590 2600
ESYLKCVVFS KVSDYKVLMG HLKTWCREHH ISNDEFPTCT QKELLSYGVT
2610 2620 2630 2640 2650
KSSVLLYKMN GMKMLRNMEK GIPLYWNPSL STRSQTYINW LAVDITDHSL
2660 2670 2680 2690 2700
RLRNRTVENG RVVNQTIMVV PLYKTDVQIF KTSPVDLEQD VQNDRLKLLS
2710 2720 2730 2740 2750
VTKAGELRWL QDWIMWRSSA VDDLNILNQV RRNKAARDHF NAKPEFKKWI
2760 2770 2780 2790 2800
KELWDYALDT TLINKKVFIT TQGSESQSTV SSGDSDSAVA PLTDEAVDEI
2810 2820 2830 2840 2850
HDLLDKELEK GTLKQIIHDA TIDAQLDIPA IESFLAEEME VFKSSLAKSH
2860 2870 2880 2890 2900
PLLLNYVRYM IQEIGVTNFR SLIDSFNQKD PLKSVSLSIL DLKEVFKFVY
2910
QDINDAYFVK QEEDHKFDF
Length:2,919
Mass (Da):336,877
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16FB7BC57FB12FC0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D31879 Genomic RNA Translation: BAA06677.1

NCBI Reference Sequences

More...
RefSeqi
NP_620522.1, NC_003755.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
962685

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:962685

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31879 Genomic RNA Translation: BAA06677.1
RefSeqiNP_620522.1, NC_003755.1

3D structure databases

SMRiQ85431
ModBaseiSearch...

Proteomic databases

PRIDEiQ85431

Genome annotation databases

GeneIDi962685
KEGGivg:962685

Family and domain databases

InterProiView protein in InterPro
IPR022531 DUF3770
IPR029124 L_protein_N
IPR003323 OTU_dom
IPR007099 RNA-dir_pol_NSvirus
IPR015842 RNA-dir_pol_tenuivirus
IPR007322 RNA_pol_bunyavir
PfamiView protein in Pfam
PF04196 Bunya_RdRp, 1 hit
PF12603 DUF3770, 1 hit
PF15518 L_protein_N, 1 hit
PF02338 OTU, 1 hit
PIRSFiPIRSF036873 L_TenuV, 1 hit
PROSITEiView protein in PROSITE
PS50802 OTU, 1 hit
PS50525 RDRP_SSRNA_NEG_SEG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRDRP_RSVT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q85431
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: November 1, 1996
Last modified: June 5, 2019
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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