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Protein

DNA polymerase catalytic subunit

Gene

UL54

Organism
Rat cytomegalovirus (strain Maastricht)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication, Viral DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase catalytic subunit (EC:2.7.7.7)
Gene namesi
Name:UL54
OrganismiRat cytomegalovirus (strain Maastricht)
Taxonomic identifieri79700 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeMuromegalovirus
Virus hostiRattus [TaxID: 10114]
Proteomesi
  • UP000008288 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000465091 – 1173DNA polymerase catalytic subunitAdd BLAST1173

Proteomic databases

PRIDEiQ85428

Structurei

3D structure databases

ProteinModelPortaliQ85428
SMRiQ85428
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.Curated

Phylogenomic databases

KOiK18964
OrthoDBiVOG0900001M

Family and domain databases

Gene3Di3.30.420.10, 1 hit
3.90.1600.10, 3 hits
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR023211 DNA_pol_palm_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 1 hit
PRINTSiPR00106 DNAPOLB
SMARTiView protein in SMART
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 2 hits
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

Sequencei

Sequence statusi: Complete.

Q85428-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAEIFFNPY LHTKRSRRDW RAEPAADNKE SFLQIVPRGV LYDGATGLIK
60 70 80 90 100
TQCELSPRMF FEDREYVLDP VMVWPGLDIA ADGEAVPPCD FVFHTFDQVV
110 120 130 140 150
SLVFAEGRGR ARRWRQHISP AGNVIRLFGA TALGTPVCVN VFGQKSYFYC
160 170 180 190 200
ENRPGEDLRD VIHDLADASR SPGPLSASPS RRAPLVAVRL RPGDIPHLYR
210 220 230 240 250
VSFNNWSMAR KVGALMVQEG RRAYEIGVDP LARFLIDRKI PSFGWLRVGR
260 270 280 290 300
FSRRCNGQTS TAVIELDCQV GDVVAGQPLP NWPPYRCLSF DIECMSASGA
310 320 330 340 350
FPQAEVLDDI VIQISCVCFV VGGSGAHRFT FAEKHLFTIG SCAPVEDVWV
360 370 380 390 400
YTFPSEYEML LGFFIFFNRF SPDFLTGYNI NGFDIKYLLH RMCRVYQKDA
410 420 430 440 450
GRFTKLRRGG RFFVNSPDGS GDAFGGRSGV IKVFCAGTVV LDMYPVCSAK
460 470 480 490 500
TSAPNYKLDT MAERYLGQRK EDLSYKEIPV AFLGGEEGRA RVGKYCVQDG
510 520 530 540 550
ARQGPLNVIA YHYEAAASPN LARIPLRRVI FDGQQIRIYT CILEECSARG
560 570 580 590 600
MVLPSLPSSP PSSGGDGAGL EGGDGGTAGR RKKKRSGSAP DGEDEDDPEG
610 620 630 640 650
GDEGENGECR ENGLEKEGSQ GSASGNVGYQ GATVLAPECG YHHNPILVFD
660 670 680 690 700
FASLYPSIIM SNNLCYSTLL VDGSPPVPDE DVLEVVVGEA TRYRFVREHV
710 720 730 740 750
RRSLLAELLV RWLKQRKLVR DAMKACGDEK QRMFMDKQQL ALKVTCNAFY
760 770 780 790 800
GFTGVAAPML PCLPIAASIT KIGRDMLLAT SAYMERHCND VEFLVSEVGV
810 820 830 840 850
PREAVDRDAL RVKIVYGDTD SVFVGFRGIG REVLVKVAGK LAAAVTRDLF
860 870 880 890 900
RDPVRLEFEK MFVSLMMICK KRYIGKVYGE NKLCMKGVDL VRRHACAFVR
910 920 930 940 950
SIVSEVVDVI FHDEAVSEGA MRLSEMSFEE LRRQGVPVGF FPVIRRLCDA
960 970 980 990 1000
RDDLFLDRVP VAQLVLSSVL SQDASRYKQK NLPHLAVYRS LVERGEELPG
1010 1020 1030 1040 1050
VGDRIEYVLT CPDESKKRAP NYEVAEDPAH VREAKIPIHA EKYFDQIVKA
1060 1070 1080 1090 1100
VTNVLLPVFP KDMPRRERFF AYVLPIRTYL PEVFLRMSKE DRECGAYLAR
1110 1120 1130 1140 1150
ESGLGMNSFI VYGEDTCGSR VGEGPGRGEG LGVGGGEGTR PPRKNGHARL
1160 1170
VSGCLYGSRP FNKKDRFVTL HIE
Length:1,173
Mass (Da):130,496
Last modified:July 11, 2001 - v2
Checksum:i900199F268F95DC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF232689 Genomic DNA Translation: AAF99153.1
RefSeqiNP_064160.1, NC_002512.2

Genome annotation databases

GeneIDi940420
KEGGivg:940420

Entry informationi

Entry nameiDPOL_RCMVM
AccessioniPrimary (citable) accession number: Q85428
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 11, 2001
Last modified: May 23, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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