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UniProtKB - Q84W41 (GLR36_ARATH)
Protein
Glutamate receptor 3.6
Gene
GLR3.6
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Glutamate-gated receptor that probably acts as non-selective cation channel. Mediates leaf-to-leaf wound signaling. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.
1 PublicationGO - Molecular functioni
- calcium channel activity Source: UniProtKB
- glutamate receptor activity Source: UniProtKB
- ligand-gated ion channel activity Source: GO_Central
- signaling receptor activity Source: GO_Central
GO - Biological processi
- calcium ion transport Source: UniProtKB
- calcium-mediated signaling Source: UniProtKB
- cell-cell signaling Source: UniProtKB
- cellular response to amino acid stimulus Source: UniProtKB
- induced systemic resistance, jasmonic acid mediated signaling pathway Source: UniProtKB
- response to wounding Source: UniProtKB
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Protein family/group databases
TCDBi | 1.A.10.1.24, the glutamate-gated ion channel (gic) family of neurotransmitter receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate receptor 3.6Alternative name(s): Ligand-gated ion channel 3.6 |
Gene namesi | Name:GLR3.6 Ordered Locus Names:At3g51480 ORF Names:F26O13.120 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT3G51480 |
TAIRi | locus:2081805, AT3G51480 |
Subcellular locationi
Other locations
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 576 | ExtracellularSequence analysisAdd BLAST | 551 | |
Transmembranei | 577 – 597 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 598 – 606 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 607 – 627 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 628 – 638 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 639 – 659 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 660 – 821 | ExtracellularSequence analysisAdd BLAST | 162 | |
Transmembranei | 822 – 842 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 843 – 903 | CytoplasmicSequence analysisAdd BLAST | 61 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Disruption phenotypei
Reduced wound-activated surface potential changes (WASP) duration in the systemic leaves, resulting in a decreased induction of the regulators of jasmonate-signaling. Glr3.3 and glr3.6 double mutant has no detectable changes in surface potential in systemic leaves and the induction of the regulators of jasmonate-signaling is more strongly decreased.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000011610 | 26 – 903 | Glutamate receptor 3.6Add BLAST | 878 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 65 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 207 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 300 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 333 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 411 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 425 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q84W41 |
PRIDEi | Q84W41 |
Expressioni
Tissue specificityi
Expressed predominantly in roots and siliques.1 Publication
Gene expression databases
ExpressionAtlasi | Q84W41, baseline and differential |
Genevisiblei | Q84W41, AT |
Interactioni
Subunit structurei
May form heteromers.
By similarityProtein-protein interaction databases
BioGRIDi | 9629, 7 interactors |
STRINGi | 3702.AT3G51480.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 881 – 903 | DisorderedSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1052, Eukaryota |
HOGENOMi | CLU_007358_0_1_1 |
InParanoidi | Q84W41 |
OrthoDBi | 188544at2759 |
PhylomeDBi | Q84W41 |
Family and domain databases
CDDi | cd19990, PBP1_GABAb_receptor_plant, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR044440, GABAb_receptor_plant_PBP1 IPR001320, Iontro_rcpt IPR017103, Iontropic_Glu_rcpt_pln IPR028082, Peripla_BP_I IPR001638, Solute-binding_3/MltF_N |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00060, Lig_chan, 1 hit PF00497, SBP_bac_3, 1 hit |
PIRSFi | PIRSF037090, Iontro_Glu-like_rcpt_pln, 1 hit |
SMARTi | View protein in SMART SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q84W41-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKWFLLMLII CNAVPLQGLT KIVSARPQVV NIGSVFTFNS LIGKVIKVAM
60 70 80 90 100
DAAVEDVNAS PSILNTTTLR IIMHDTKYNG FMSIMEPLQF MESETVAIIG
110 120 130 140 150
PQRSTTARVV AHVATELKIP ILSFSATDPT MSPLQFPFFI RTSQNDLFQM
160 170 180 190 200
AAIADIVQFY GWREVVAIYG DDDYGRNGVA ALGDRLSEKR CRISYKAALP
210 220 230 240 250
PAPTRENITD LLIKVALSES RIIVVHASFI WGLELFNVAR NLGMMSTGYV
260 270 280 290 300
WIATNWLSTI IDTDSPLPLD TINNIQGVIT LRLHTPNSIM KQNFVQRWHN
310 320 330 340 350
LTHVGLSTYA LYAYDTVWLL AQAIDDFFKK GGNVSFSKNP IISELGGGNL
360 370 380 390 400
HLDALKVFDG GKIFLESILQ VDRIGLTGRM KFTSDRNLVN PAFDVLNVIG
410 420 430 440 450
TGYTTIGYWF NHSGLSVMPA DEMENTSFSG QKLHSVVWPG HSIKIPRGWV
460 470 480 490 500
FSNNGRHLRI GVPNRYRFEE VVSVKSNGMI TGFCVDVFIA AINLLPYAVP
510 520 530 540 550
FELVAFGNGH DNPSNSELVR LITTGVYDAG VGDITIITER TKMADFTQPY
560 570 580 590 600
VESGLVVVAP VRKLGSSAMA FLRPFTPQMW LIAAASFLIV GAVIWCLEHK
610 620 630 640 650
HNDEFRGPPR RQVITTFWFS FSTLFFSHRE TTTSNLGRIV LIIWLFVVLI
660 670 680 690 700
INSSYTASLT SILTVHQLSS PIKGIETLQT NHDPIGYPQG SFVRDYLIHE
710 720 730 740 750
LNIHVSRLVP LRSPEEYDKA LRDGPGKGGV AAVVDERAYI ELFLSNRCEF
760 770 780 790 800
GIVGQEFTKN GWGFAFPRNS PLAVDVSAAI LQLSENGDMQ RIRDKWLLRK
810 820 830 840 850
ACSLQGAEIE VDRLELKSFW GLFVVCGVAC VLALAVYTVL MIRQFGQQCP
860 870 880 890 900
EEAEGSIRRR SSPSARIHSF LSFVKEKEED AKARSSRERQ LEDISANGSS
RCN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1I9LP22 | A0A1I9LP22_ARATH | Glutamate receptor | GLR3.6 ATGLR3.6, glutamate receptor 3.6, At3g51480 | 813 | Annotation score: | ||
A0A1I9LP23 | A0A1I9LP23_ARATH | Glutamate receptor | GLR3.6 ATGLR3.6, glutamate receptor 3.6, At3g51480 | 777 | Annotation score: |
Sequence cautioni
The sequence CAB63012 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL133452 Genomic DNA Translation: CAB63012.1 Sequence problems. CP002686 Genomic DNA Translation: AEE78797.1 CP002686 Genomic DNA Translation: ANM64332.1 BT004264 mRNA Translation: AAO42266.1 |
PIRi | T45779 |
RefSeqi | NP_001326369.1, NM_001339518.1 NP_190716.3, NM_115007.4 |
Genome annotation databases
EnsemblPlantsi | AT3G51480.1; AT3G51480.1; AT3G51480 AT3G51480.4; AT3G51480.4; AT3G51480 |
GeneIDi | 824311 |
Gramenei | AT3G51480.1; AT3G51480.1; AT3G51480 AT3G51480.4; AT3G51480.4; AT3G51480 |
KEGGi | ath:AT3G51480 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL133452 Genomic DNA Translation: CAB63012.1 Sequence problems. CP002686 Genomic DNA Translation: AEE78797.1 CP002686 Genomic DNA Translation: ANM64332.1 BT004264 mRNA Translation: AAO42266.1 |
PIRi | T45779 |
RefSeqi | NP_001326369.1, NM_001339518.1 NP_190716.3, NM_115007.4 |
3D structure databases
SMRi | Q84W41 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 9629, 7 interactors |
STRINGi | 3702.AT3G51480.1 |
Protein family/group databases
TCDBi | 1.A.10.1.24, the glutamate-gated ion channel (gic) family of neurotransmitter receptors |
Proteomic databases
PaxDbi | Q84W41 |
PRIDEi | Q84W41 |
Genome annotation databases
EnsemblPlantsi | AT3G51480.1; AT3G51480.1; AT3G51480 AT3G51480.4; AT3G51480.4; AT3G51480 |
GeneIDi | 824311 |
Gramenei | AT3G51480.1; AT3G51480.1; AT3G51480 AT3G51480.4; AT3G51480.4; AT3G51480 |
KEGGi | ath:AT3G51480 |
Organism-specific databases
Araporti | AT3G51480 |
TAIRi | locus:2081805, AT3G51480 |
Phylogenomic databases
eggNOGi | KOG1052, Eukaryota |
HOGENOMi | CLU_007358_0_1_1 |
InParanoidi | Q84W41 |
OrthoDBi | 188544at2759 |
PhylomeDBi | Q84W41 |
Miscellaneous databases
PROi | PR:Q84W41 |
Gene expression databases
ExpressionAtlasi | Q84W41, baseline and differential |
Genevisiblei | Q84W41, AT |
Family and domain databases
CDDi | cd19990, PBP1_GABAb_receptor_plant, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR044440, GABAb_receptor_plant_PBP1 IPR001320, Iontro_rcpt IPR017103, Iontropic_Glu_rcpt_pln IPR028082, Peripla_BP_I IPR001638, Solute-binding_3/MltF_N |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00060, Lig_chan, 1 hit PF00497, SBP_bac_3, 1 hit |
PIRSFi | PIRSF037090, Iontro_Glu-like_rcpt_pln, 1 hit |
SMARTi | View protein in SMART SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GLR36_ARATH | |
Accessioni | Q84W41Primary (citable) accession number: Q84W41 Secondary accession number(s): Q9SD01 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | June 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families