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Entry version 152 (02 Jun 2021)
Sequence version 1 (01 Jun 2003)
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Protein

AIR carboxylase

Gene

At2g37690

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route).ARBA annotation This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDecarboxylaseARBA annotation, Lyase
Biological processPurine biosynthesisARBA annotation
LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
ARA:AT2G37690-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00074;UER00130

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AIR carboxylaseARBA annotation (EC:4.1.1.21ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:At2g37690Imported
ORF Names:F13M22.19Imported, F13M22_19Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

The Arabidopsis Information Resource

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TAIRi
locus:2040771, AT2G37690

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
187795

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT2G37690.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini194 – 382ATP-graspInterPro annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni55 – 83DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi55 – 75Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2835, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011534_2_1_1

Identification of Orthologs from Complete Genome Data

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OMAi
DGWESYL

Database of Orthologous Groups

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OrthoDBi
945274at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.20, 1 hit
3.40.50.7700, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01929, PurE_classI, 1 hit
MF_01928, PurK, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016301, Ade2_fungi/plant
IPR011761, ATP-grasp
IPR003135, ATP-grasp_carboxylate-amine
IPR013815, ATP_grasp_subdomain_1
IPR016185, PreATP-grasp_dom_sf
IPR033747, PurE_ClassI
IPR000031, PurE_dom
IPR035893, PurE_sf
IPR005875, PurK
IPR040686, PurK_C
IPR011054, Rudment_hybrid_motif

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00731, AIRC, 1 hit
PF02222, ATP-grasp, 1 hit
PF17769, PurK_C, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF001340, AIR_carboxylase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01001, AIRC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51246, SSF51246, 1 hit
SSF52255, SSF52255, 1 hit
SSF52440, SSF52440, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01162, purE, 1 hit
TIGR01161, purK, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50975, ATP_GRASP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q84TI2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLLKQSSAA VLVVGNTTPV LHTSRSTYRV GPFPVTRTQS FQSLTMANLQ
60 70 80 90 100
KLPTSSSGKL NTASAVPCSS HDASPISENR ENKHVHGVSE KIVGVLGGGQ
110 120 130 140 150
LGRMLCQAAS QLAIKVMILD PSKNCSASAL SYGHMVDSFD DSATVEEFAK
160 170 180 190 200
RCGVLTVEIE HVDVDTLEKL EKQGVDCQPK ASTIRIIQDK YMQKVHFSQH
210 220 230 240 250
GIPLPEFMEI SDIEGARKAG ELFGYPLMIK SKRLAYDGRG NAVANNQDEL
260 270 280 290 300
SSAVTALGGF SRGLYIEKWA PFVKELAVIV ARGRDGSMVC YPVVETIHRD
310 320 330 340 350
NICHIVKAPA DVPWKINKLA TDVAQKAVGS LEGAGVFAVE LFLTEDSQIL
360 370 380 390 400
LNEVAPRPHN SGHQTIECCY TSQFEQHLRA VVGLPLGDPS MRTPASIMYN
410 420 430 440 450
ILGEDDGEAG FKLAHRLIAR ALCIPGASVH WYDKPEMRKQ RKMGHITLVG
460 470 480 490 500
QSMGILEQRL QCILSEQSHQ VHETPRVAII MGSDTDLPVM KDAAKILDLF
510 520 530 540 550
GVTHEVKIVS AHRTPEMMYT YATSAHSRGV QVIIAGAGGA AHLPGMVASL
560 570 580 590 600
TPLPVIGVPV RATRLDGVDS LLSIVQMPRG VPVATVAINN ATNAALLAVR
610 620 630 640
MLGISDTDLV SRMRQYQEDM RDENLNKGEK LETEGWESYL NQ
Length:642
Mass (Da):69,752
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2BA8FACC864B37C1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BT005770 mRNA Translation: AAO64174.1
BT008606 mRNA Translation: AAP40431.1
CP002685 Genomic DNA Translation: AEC09435.1
AK228627 mRNA Translation: BAF00537.1

NCBI Reference Sequences

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RefSeqi
NP_181305.2, NM_129325.6

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G37690.1; AT2G37690.1; AT2G37690

Database of genes from NCBI RefSeq genomes

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GeneIDi
818346

Gramene; a comparative resource for plants

More...
Gramenei
AT2G37690.1; AT2G37690.1; AT2G37690

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G37690

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT005770 mRNA Translation: AAO64174.1
BT008606 mRNA Translation: AAP40431.1
CP002685 Genomic DNA Translation: AEC09435.1
AK228627 mRNA Translation: BAF00537.1
RefSeqiNP_181305.2, NM_129325.6

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3702.AT2G37690.1

Proteomic databases

ProteomicsDBi187795

Genome annotation databases

EnsemblPlantsiAT2G37690.1; AT2G37690.1; AT2G37690
GeneIDi818346
GrameneiAT2G37690.1; AT2G37690.1; AT2G37690
KEGGiath:AT2G37690

Organism-specific databases

TAIRilocus:2040771, AT2G37690

Phylogenomic databases

eggNOGiKOG2835, Eukaryota
HOGENOMiCLU_011534_2_1_1
OMAiDGWESYL
OrthoDBi945274at2759

Enzyme and pathway databases

UniPathwayiUPA00074;UER00130
BioCyciARA:AT2G37690-MONOMER

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
3.40.50.7700, 1 hit
HAMAPiMF_01929, PurE_classI, 1 hit
MF_01928, PurK, 1 hit
InterProiView protein in InterPro
IPR016301, Ade2_fungi/plant
IPR011761, ATP-grasp
IPR003135, ATP-grasp_carboxylate-amine
IPR013815, ATP_grasp_subdomain_1
IPR016185, PreATP-grasp_dom_sf
IPR033747, PurE_ClassI
IPR000031, PurE_dom
IPR035893, PurE_sf
IPR005875, PurK
IPR040686, PurK_C
IPR011054, Rudment_hybrid_motif
PfamiView protein in Pfam
PF00731, AIRC, 1 hit
PF02222, ATP-grasp, 1 hit
PF17769, PurK_C, 1 hit
PIRSFiPIRSF001340, AIR_carboxylase, 1 hit
SMARTiView protein in SMART
SM01001, AIRC, 1 hit
SUPFAMiSSF51246, SSF51246, 1 hit
SSF52255, SSF52255, 1 hit
SSF52440, SSF52440, 1 hit
TIGRFAMsiTIGR01162, purE, 1 hit
TIGR01161, purK, 1 hit
PROSITEiView protein in PROSITE
PS50975, ATP_GRASP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ84TI2_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q84TI2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: June 2, 2021
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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