UniProtKB - Q84MA2 (IP5P1_ARATH)
Protein
Type I inositol polyphosphate 5-phosphatase 1
Gene
IP5P1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Has phosphatase activity toward Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but not toward Ins(1,4)P2, Ins1P (PubMed:11402208). Seems to be involved in the abscisic acid (ABA) signaling pathway (PubMed:12805629). Could also be able to hydrolyze PtdIns(4,5)P2 and PtdIns(3,4,5)P3 (PubMed:23658066).3 Publications
Catalytic activityi
- 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate1 PublicationEC:3.1.3.561 Publication
- 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate1 PublicationEC:3.1.3.561 Publication
GO - Molecular functioni
- inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Source: UniProtKB-EC
- inositol-1,4,5-trisphosphate 5-phosphatase activity Source: UniProtKB-EC
- inositol-polyphosphate 5-phosphatase activity Source: TAIR
- inositol trisphosphate phosphatase activity Source: TAIR
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Source: UniProtKB
- phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Source: UniProtKB
GO - Biological processi
- abscisic acid-activated signaling pathway Source: UniProtKB-KW
- inositol phosphate dephosphorylation Source: TAIR
- inositol trisphosphate metabolic process Source: TAIR
- phosphatidylinositol dephosphorylation Source: UniProtKB
- seed germination Source: UniProtKB
- seedling development Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Biological process | Abscisic acid signaling pathway |
Enzyme and pathway databases
BioCyci | ARA:AT1G34120-MONOMER MetaCyc:AT1G34120-MONOMER |
BRENDAi | 3.1.3.56, 399 |
Names & Taxonomyi
Protein namesi | Recommended name: Type I inositol polyphosphate 5-phosphatase 11 Publication (EC:3.1.3.561 Publication)Short name: At5PTase11 Publication |
Gene namesi | Name:IP5P11 Publication Synonyms:5P11 Publication Ordered Locus Names:At1g34120Imported ORF Names:F12G12.6Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G34120 |
TAIRi | locus:2009061, AT1G34120 |
Pathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000209722 | 1 – 590 | Type I inositol polyphosphate 5-phosphatase 1Add BLAST | 590 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 60 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q84MA2 |
PRIDEi | Q84MA2 |
ProteomicsDBi | 232224 [Q84MA2-1] |
PTM databases
iPTMneti | Q84MA2 |
Expressioni
Tissue specificityi
Expressed ubiquitously.2 Publications
Inductioni
Induced by ABA at both transcript and protein levels in a specific, transient manner.1 Publication
Gene expression databases
ExpressionAtlasi | Q84MA2, baseline and differential |
Genevisiblei | Q84MA2, AT |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 445 – 460 | Catalytic 11 PublicationAdd BLAST | 16 | |
Regioni | 523 – 538 | Catalytic 21 PublicationAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the inositol polyphosphate 5-phosphatase family.Curated
Phylogenomic databases
eggNOGi | KOG0565, Eukaryota |
InParanoidi | Q84MA2 |
OrthoDBi | 1399831at2759 |
PhylomeDBi | Q84MA2 |
Family and domain databases
Gene3Di | 3.60.10.10, 2 hits |
InterProi | View protein in InterPro IPR036691, Endo/exonu/phosph_ase_sf IPR005135, Endo/exonuclease/phosphatase IPR000300, IPPc |
Pfami | View protein in Pfam PF03372, Exo_endo_phos, 1 hit |
SMARTi | View protein in SMART SM00128, IPPc, 1 hit |
SUPFAMi | SSF56219, SSF56219, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketNote: Additional isoforms seem to exist.
This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q84MA2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEVRSRSRR TESNWATICC SAFSCLQLYW ARIVLRKWFN VSASESDYSA
60 70 80 90 100
DSDDDYEDRS QEFDPISSGV TNPRVDTDGN VIYRPKLRRR NSETFRMQYI
110 120 130 140 150
DTKAIRICAG TWNVGGRVPS SDLDIDGWLD TLEPADIYVL GLQEIVPLNA
160 170 180 190 200
GNIFGMEDDQ PALEWENLIR DALNRVQPRK LKIKSHSDPP SPSKFKQPEE
210 220 230 240 250
VPYSVEDMFV ETSHDACDGI SSMDNKLNSV ESTDVPIVSE DSLTNIDVLG
260 270 280 290 300
STNDNASCLP IQEYLQRQFS TPNTPDRSLS MQINSDSKRE ERFSYTERVG
310 320 330 340 350
LSWPEPPLRL LNQYVSERRG SFKSVNLTIT NLRKPSYVRI VSKQMVGVFL
360 370 380 390 400
TIWVRRNLRK HISNLCVSTV GVGIMGYIGN KGSVSVSMSI YQTPFCFLCT
410 420 430 440 450
HLSSGEKDTD QEKRNDDVRE IHRRTQFLPH SLNANELPRS ICNHERIIWL
460 470 480 490 500
GDLNYRINLS YEKTHELIAR KEWQRLVEYD QLSREMTKGN LFEGWSEGTL
510 520 530 540 550
DFAPTYKYEI DSENYIGDDP ESGKRRPAWC DRIIWNGKGM KLFNYRRNEI
560 570 580 590
KLSDHRPVTA TFLAEVEVLS PRKLQHALTL TYAEIQGLDA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1P8AUF0 | A0A1P8AUF0_ARATH | Inositol polyphosphate 5-phosphatas... | IP5PI AT5P1, AT5PTASE1, ATIP5PI, At1g34120, F12G12.6 | 475 | Annotation score: | ||
A0A1P8AUF3 | A0A1P8AUF3_ARATH | Inositol polyphosphate 5-phosphatas... | IP5PI AT5P1, AT5PTASE1, ATIP5PI, At1g34120, F12G12.6 | 435 | Annotation score: | ||
F4HT46 | F4HT46_ARATH | Inositol polyphosphate 5-phosphatas... | IP5PI AT5P1, AT5PTASE1, ATIP5PI, At1g34120, F12G12.6 | 589 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 21 | S → L in AAG17824 (PubMed:11340187).Curated | 1 | |
Sequence conflicti | 80 | N → D in AAD10828 (Ref. 2) Curated | 1 | |
Sequence conflicti | 239 | S → G in AAD10828 (Ref. 2) Curated | 1 | |
Sequence conflicti | 478 | E → K in AAD10828 (Ref. 2) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013848 | 79 – 83 | GNVIY → D in isoform 2. 3 Publications | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF289633 mRNA Translation: AAG17824.1 AF117062 mRNA Translation: AAD10828.1 AC015446 Genomic DNA Translation: AAG12525.1 CP002684 Genomic DNA Translation: AEE31672.1 CP002684 Genomic DNA Translation: AEE31674.1 BT006448 mRNA Translation: AAP21256.1 AK227368 mRNA Translation: BAE99376.1 |
PIRi | C86465 |
RefSeqi | NP_564437.1, NM_103135.4 [Q84MA2-2] NP_849745.1, NM_179414.1 [Q84MA2-1] |
Genome annotation databases
EnsemblPlantsi | AT1G34120.1; AT1G34120.1; AT1G34120 [Q84MA2-2] AT1G34120.2; AT1G34120.2; AT1G34120 [Q84MA2-1] |
GeneIDi | 840311 |
Gramenei | AT1G34120.1; AT1G34120.1; AT1G34120 [Q84MA2-2] AT1G34120.2; AT1G34120.2; AT1G34120 [Q84MA2-1] |
KEGGi | ath:AT1G34120 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF289633 mRNA Translation: AAG17824.1 AF117062 mRNA Translation: AAD10828.1 AC015446 Genomic DNA Translation: AAG12525.1 CP002684 Genomic DNA Translation: AEE31672.1 CP002684 Genomic DNA Translation: AEE31674.1 BT006448 mRNA Translation: AAP21256.1 AK227368 mRNA Translation: BAE99376.1 |
PIRi | C86465 |
RefSeqi | NP_564437.1, NM_103135.4 [Q84MA2-2] NP_849745.1, NM_179414.1 [Q84MA2-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 3702.AT1G34120.2 |
PTM databases
iPTMneti | Q84MA2 |
Proteomic databases
PaxDbi | Q84MA2 |
PRIDEi | Q84MA2 |
ProteomicsDBi | 232224 [Q84MA2-1] |
Genome annotation databases
EnsemblPlantsi | AT1G34120.1; AT1G34120.1; AT1G34120 [Q84MA2-2] AT1G34120.2; AT1G34120.2; AT1G34120 [Q84MA2-1] |
GeneIDi | 840311 |
Gramenei | AT1G34120.1; AT1G34120.1; AT1G34120 [Q84MA2-2] AT1G34120.2; AT1G34120.2; AT1G34120 [Q84MA2-1] |
KEGGi | ath:AT1G34120 |
Organism-specific databases
Araporti | AT1G34120 |
TAIRi | locus:2009061, AT1G34120 |
Phylogenomic databases
eggNOGi | KOG0565, Eukaryota |
InParanoidi | Q84MA2 |
OrthoDBi | 1399831at2759 |
PhylomeDBi | Q84MA2 |
Enzyme and pathway databases
BioCyci | ARA:AT1G34120-MONOMER MetaCyc:AT1G34120-MONOMER |
BRENDAi | 3.1.3.56, 399 |
Miscellaneous databases
PROi | PR:Q84MA2 |
Gene expression databases
ExpressionAtlasi | Q84MA2, baseline and differential |
Genevisiblei | Q84MA2, AT |
Family and domain databases
Gene3Di | 3.60.10.10, 2 hits |
InterProi | View protein in InterPro IPR036691, Endo/exonu/phosph_ase_sf IPR005135, Endo/exonuclease/phosphatase IPR000300, IPPc |
Pfami | View protein in Pfam PF03372, Exo_endo_phos, 1 hit |
SMARTi | View protein in SMART SM00128, IPPc, 1 hit |
SUPFAMi | SSF56219, SSF56219, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IP5P1_ARATH | |
Accessioni | Q84MA2Primary (citable) accession number: Q84MA2 Secondary accession number(s): Q0WU22 Q9ZSC4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | June 7, 2005 | |
Last modified: | April 7, 2021 | |
This is version 126 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families