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Entry version 136 (12 Aug 2020)
Sequence version 1 (01 Jun 2003)
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Protein

rRNA (cytosine-C(5))-methyltransferase NOP2C

Gene

NOP2C

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in ribosomal large subunit assembly (By similarity). S-adenosyl-L-methionine-dependent methyltransferase that may methylates the C5 position of cytosine in rRNA (By similarity). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (By similarity). Seems involved in the regulation of cell proliferation (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei328S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei355S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei465S-adenosyl-L-methioninePROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei516NucleophilePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
Biological processRibosome biogenesis, rRNA processing
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
rRNA (cytosine-C(5))-methyltransferase NOP2CCurated (EC:2.1.1.-PROSITE-ProRule annotation)
Alternative name(s):
Nucleolar protein 2C1 Publication
tRNA methyltransferase 4f1 Publication
Short name:
AtTRM4f1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOP2C1 Publication
Synonyms:TRM4f1 Publication
Ordered Locus Names:At1g06560Imported
ORF Names:F12K11.10Imported, F12K11.11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G06560

The Arabidopsis Information Resource

More...
TAIRi
locus:2009170, AT1G06560

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Normal levels of methylation at cytosine 2860 of 25S rRNA.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004488931 – 599rRNA (cytosine-C(5))-methyltransferase NOP2CAdd BLAST599

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q84MA1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
185604

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q84MA1, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT1G06560.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q84MA1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini158 – 265PUAPROSITE-ProRule annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni304 – 310S-adenosyl-L-methionine bindingPROSITE-ProRule annotation7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1122, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005316_1_0_1

KEGG Orthology (KO)

More...
KOi
K21971

Identification of Orthologs from Complete Genome Data

More...
OMAi
VCVAVEQ

Database of Orthologous Groups

More...
OrthoDBi
1040075at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018314, Fmu/NOL1/Nop2p_CS
IPR001678, MeTrfase_RsmB/NOP2
IPR002478, PUA
IPR015947, PUA-like_sf
IPR023267, RCMT
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01189, Methyltr_RsmB-F, 2 hits
PF01472, PUA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02008, RCMTFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00359, PUA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335, SSF53335, 1 hit
SSF88697, SSF88697, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01153, NOL1_NOP2_SUN, 1 hit
PS50890, PUA, 1 hit
PS51686, SAM_MT_RSMB_NOP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q84MA1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKARVLLKP SSLTTCLTRA KAFFSSVSQS RSISHQMEMG PSDSERYCYD
60 70 80 90 100
PVLRWNPEVE DYFTKAYGPD HFARISKALT RPSSYSCIRV NTVKTTSDAV
110 120 130 140 150
IEKLTKILND SEEGLKLVQP DGSSPVTKCQ IPGLDYVVFV NGSGPHKIEY
160 170 180 190 200
DSGLENPPKE VLVSRKCAEA VLRGAQVYVP GVLACTAHVE KGDAVAVCVA
210 220 230 240 250
MEQPGDEGDW SVNMTRGTTL QGLPTDPYYR ERSGLYIGMG TAMLSRAGMF
260 270 280 290 300
RVPNGIAVDL NHRVFRLPSL HNILEGEIFL QNLPSIIVAH ALDPQKGERI
310 320 330 340 350
LDMCAAPGGK TTAIAILMND EGEIVAADRS HNKVLVVQNL SAEMGFTCIT
360 370 380 390 400
TCKLDALKSV CLPTTLNEST ILINGDNSSS MTSHSELSSN EEMTSVTSRR
410 420 430 440 450
SEADKSCEKN DSTEQPNGGD NVSQAYIRKN KGRLKNGRGR TQCQGGRAGK
460 470 480 490 500
SQGFPPNSFD RVLLDAPCSA LGLRPRLFAG LETVVSLRNH GWYQRKMLDQ
510 520 530 540 550
AVQLVRVGGI LVYSTCTINP SENEAVVRYA LDKYRFLSLA PQHPRIGGPG
560 570 580 590
LVGRCEFPDG YIEEWLKPGE EELVQKFDPS SELDTIGFFI AKFSVGPKD
Length:599
Mass (Da):65,513
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2DCB8D28502CBF7
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF24825 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF24826 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC007592 Genomic DNA Translation: AAF24825.1 Sequence problems.
AC007592 Genomic DNA Translation: AAF24826.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28005.1
BT006450 mRNA Translation: AAP21258.1
AK227718 mRNA Translation: BAE99704.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A86201

NCBI Reference Sequences

More...
RefSeqi
NP_172143.3, NM_100535.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G06560.1; AT1G06560.1; AT1G06560

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
837167

Gramene; a comparative resource for plants

More...
Gramenei
AT1G06560.1; AT1G06560.1; AT1G06560

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G06560

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007592 Genomic DNA Translation: AAF24825.1 Sequence problems.
AC007592 Genomic DNA Translation: AAF24826.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28005.1
BT006450 mRNA Translation: AAP21258.1
AK227718 mRNA Translation: BAE99704.1
PIRiA86201
RefSeqiNP_172143.3, NM_100535.4

3D structure databases

SMRiQ84MA1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G06560.1

Proteomic databases

PRIDEiQ84MA1
ProteomicsDBi185604

Genome annotation databases

EnsemblPlantsiAT1G06560.1; AT1G06560.1; AT1G06560
GeneIDi837167
GrameneiAT1G06560.1; AT1G06560.1; AT1G06560
KEGGiath:AT1G06560

Organism-specific databases

AraportiAT1G06560
TAIRilocus:2009170, AT1G06560

Phylogenomic databases

eggNOGiKOG1122, Eukaryota
HOGENOMiCLU_005316_1_0_1
KOiK21971
OMAiVCVAVEQ
OrthoDBi1040075at2759

Gene expression databases

ExpressionAtlasiQ84MA1, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR018314, Fmu/NOL1/Nop2p_CS
IPR001678, MeTrfase_RsmB/NOP2
IPR002478, PUA
IPR015947, PUA-like_sf
IPR023267, RCMT
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF01189, Methyltr_RsmB-F, 2 hits
PF01472, PUA, 1 hit
PRINTSiPR02008, RCMTFAMILY
SMARTiView protein in SMART
SM00359, PUA, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit
SSF88697, SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS01153, NOL1_NOP2_SUN, 1 hit
PS50890, PUA, 1 hit
PS51686, SAM_MT_RSMB_NOP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOP2C_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q84MA1
Secondary accession number(s): Q9SHJ9, Q9SHK0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2020
Last sequence update: June 1, 2003
Last modified: August 12, 2020
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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