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Protein

Carotenoid 9,10(9',10')-cleavage dioxygenase

Gene

CCD

Organism
Crocus sativus (Saffron)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves a variety of carotenoids symmetrically at both the 9-10 and 9'-10' double bonds. Catalyzes the formation of 4,9-dimethyldodeca-2,4,6,8,10-pentaene-1,12-dialdehyde and probably hydroxydihydro-beta-ionone from zeaxanthin.1 Publication

Catalytic activityi

Zeaxanthin + 2 O2 = 4,9-dimethyl-dodeca-2,4,6,8,10-pentaen-dial + 2 (3R)-3-hydroxy-beta-ionone.1 Publication

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi226Iron; catalyticBy similarity1
Metal bindingi274Iron; catalyticBy similarity1
Metal bindingi340Iron; catalyticBy similarity1
Metal bindingi530Iron; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Carotenoid 9,10(9',10')-cleavage dioxygenase (EC:1.14.99.n4)
Alternative name(s):
CsCCD
Gene namesi
Name:CCD
OrganismiCrocus sativus (Saffron)
Taxonomic identifieri82528 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaAsparagalesIridaceaeCrocus

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002826061 – 546Carotenoid 9,10(9',10')-cleavage dioxygenaseAdd BLAST546

Expressioni

Tissue specificityi

In vegetative and floral tissues.1 Publication

Inductioni

Constitutively expressed at low level in all tissues.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ84KG5
SMRiQ84KG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the carotenoid oxygenase family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR004294 Carotenoid_Oase
PANTHERiPTHR10543 PTHR10543, 1 hit
PfamiView protein in Pfam
PF03055 RPE65, 1 hit

Sequencei

Sequence statusi: Complete.

Q84KG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEVAKEEVE ERRSIVAVNP QPSKGLVSSA VDLIEKAVVY LFHDKSKPCH
60 70 80 90 100
YLSGNFAPVV DETPPCPDLP VRGHLPECLN GEFVRVGPNP KFMPVAGYHW
110 120 130 140 150
FDGDGMIHGM RIKDGKATYA SRYVKTSRLK QEEYFEGPKF MKIGDLKGFF
160 170 180 190 200
GLFMVQMQLL RAKLKVIDVS YGVGTGNTAL IYHHGKLLAL SEADKPYVVK
210 220 230 240 250
VLEDGDLQTL GLLDYDKRLS HSFTAHPKVD PFTDEMFTFG YAHTPPYVTY
260 270 280 290 300
RVISKDGVMR DPVPITIPAS VMMHDFAITE NYSIFMDLPL YFQPKEMVKG
310 320 330 340 350
GKLIFSFDAT KKARFGVLPR YAKDDSLIRW FELPNCFIFH NANAWEEGDE
360 370 380 390 400
VVLITCRLEN PDLDMVNGAV KEKLENFKNE LYEMRFNMKT GAASQKQLSV
410 420 430 440 450
SAVDFPRINE SYTTRKQRYV YGTILDNITK VKGIIKFDLH AEPEAGKKKL
460 470 480 490 500
EVGGNVQGIF DLGPGRYGSE AVFVPRERGI KSEEDDGYLI FFVHDENTGK
510 520 530 540
SEVNVIDAKT MSAEPVAVVE LPNRVPYGFH AFFVNEEQLQ WQQTDV
Length:546
Mass (Da):61,697
Last modified:June 1, 2003 - v1
Checksum:i5267DA28454189D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132927 mRNA Translation: CAC79592.1

Similar proteinsi

Entry informationi

Entry nameiCCD_CROSA
AccessioniPrimary (citable) accession number: Q84KG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: June 1, 2003
Last modified: March 15, 2017
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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