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Protein

Homeobox protein knotted-1-like 6

Gene

KNAT6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in meristem function. Contributes to the shoot apical meristem (SAM) maintenance and organ separation by controlling boundary establishment in embryo in a CUC1, CUC2 and STM-dependent manner. Involved in maintaining cells in an undifferentiated, meristematic state. Probably binds to the DNA sequence 5'-TGAC-3'.1 Publication

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi245 – 308Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

  • DNA binding transcription factor activity Source: TAIR
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • meristem maintenance Source: TAIR

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein knotted-1-like 6
Alternative name(s):
Protein KNAT6
Gene namesi
Name:KNAT6
Ordered Locus Names:At1g23380
ORF Names:F26F24.25, F28C11.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G23380
TAIRilocus:2028075 AT1G23380

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003118181 – 327Homeobox protein knotted-1-like 6Add BLAST327

Proteomic databases

PaxDbiQ84JS6

PTM databases

iPTMnetiQ84JS6

Expressioni

Tissue specificityi

Expressed predominantly in shoot apices of seedlings, and, to a lower extent, in rosette leaves.1 Publication

Developmental stagei

First detected in torpedo stage embryos at the boundaries between the presumptive SAM and the cotyledons. Later expressed between the cotyledons and the meristem, and between the cotyledons. In seedlings, localised in stipules and at the boundaries between the SAM and the emerging primordia. Expressed at the site of lateral roots.1 Publication

Inductioni

Seems to be repressed by AS2 and AS1 but induced by STM, CUC1 and CUC2.2 Publications

Gene expression databases

ExpressionAtlasiQ84JS6 baseline and differential
GenevisibleiQ84JS6 AT

Interactioni

Subunit structurei

May form heterodimeric complex with the TALE/BELL protein BLH9/PNY. Interacts with OFP2 and OFP4.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi24185, 15 interactors
IntActiQ84JS6, 18 interactors
STRINGi3702.AT1G23380.2

Structurei

3D structure databases

ProteinModelPortaliQ84JS6
SMRiQ84JS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini224 – 244ELKPROSITE-ProRule annotationAdd BLAST21

Sequence similaritiesi

Belongs to the TALE/KNOX homeobox family.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
HOGENOMiHOG000272741
InParanoidiQ84JS6
OMAiDYQALLC
PhylomeDBiQ84JS6

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR005539 ELK_dom
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR005540 KNOX1
IPR005541 KNOX2
PfamiView protein in Pfam
PF03789 ELK, 1 hit
PF05920 Homeobox_KN, 1 hit
PF03790 KNOX1, 1 hit
PF03791 KNOX2, 1 hit
SMARTiView protein in SMART
SM01188 ELK, 1 hit
SM00389 HOX, 1 hit
SM01255 KNOX1, 1 hit
SM01256 KNOX2, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51213 ELK, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform KNAT6S (identifier: Q84JS6-1) [UniParc]FASTAAdd to basket
Also known as: short

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGMYNFHSA GDYSDKSVLM MSPESLMFPS DYQALLCSSA GENRVSDVFG
60 70 80 90 100
SDELLSVAVS ALSSEAASIA PEIRRNDDNV SLTVIKAKIA CHPSYPRLLQ
110 120 130 140 150
AYIDCQKVGA PPEIACLLEE IQRESDVYKQ EVVPSSCFGA DPELDEFMET
160 170 180 190 200
YCDILVKYKS DLARPFDEAT CFLNKIEMQL RNLCTGVESA RGVSEDGVIS
210 220 230 240 250
SDEELSGGDH EVAEDGRQRC EDRDLKDRLL RKFGSRISTL KLEFSKKKKK
260 270 280 290 300
GKLPREARQA LLDWWNLHYK WPYPTEGDKI ALADATGLDQ KQINNWFINQ
310 320
RKRHWKPSEN MPFAMMDDSS GSFFTEE
Length:327
Mass (Da):36,934
Last modified:June 1, 2003 - v1
Checksum:i71147EAD25CD2908
GO
Isoform KNAT6L (identifier: Q84JS6-2) [UniParc]FASTAAdd to basket
Also known as: long

The sequence of this isoform differs from the canonical sequence as follows:
     107-107: K → KKQ

Show »
Length:329
Mass (Da):37,190
Checksum:iCF8B7F527A6BAEE8
GO

Sequence cautioni

The sequence AAF79598 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAF79598 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF87007 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029601107K → KKQ in isoform KNAT6L. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005292 Genomic DNA Translation: AAF87007.1 Different initiation.
AC007945 Genomic DNA Translation: AAF79598.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE30380.1
CP002684 Genomic DNA Translation: AEE30381.1
BT002930 mRNA Translation: AAO22744.1
BT004370 mRNA Translation: AAO42364.1
AB072361 mRNA Translation: BAB69678.1
AB072362 mRNA Translation: BAB69679.1
RefSeqiNP_173752.3, NM_102187.4 [Q84JS6-2]
NP_850951.2, NM_180620.3 [Q84JS6-1]
UniGeneiAt.26286

Genome annotation databases

EnsemblPlantsiAT1G23380.1; AT1G23380.1; AT1G23380 [Q84JS6-1]
AT1G23380.2; AT1G23380.2; AT1G23380 [Q84JS6-2]
GeneIDi838946
GrameneiAT1G23380.1; AT1G23380.1; AT1G23380 [Q84JS6-1]
AT1G23380.2; AT1G23380.2; AT1G23380 [Q84JS6-2]
KEGGiath:AT1G23380

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKNAT6_ARATH
AccessioniPrimary (citable) accession number: Q84JS6
Secondary accession number(s): Q948K0, Q9LQD4, Q9LR21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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