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Entry version 127 (11 Dec 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Cellulose synthase A catalytic subunit 4 [UDP-forming]

Gene

CESA4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation. Involved in the secondary cell wall formation. Required for the xylem cell wall thickening.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: plant cellulose biosynthesis

This protein is involved in the pathway plant cellulose biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway plant cellulose biosynthesis and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi23Zinc 1By similarity1
Metal bindingi26Zinc 1By similarity1
Metal bindingi42Zinc 2By similarity1
Metal bindingi45Zinc 2By similarity1
Metal bindingi50Zinc 1By similarity1
Metal bindingi53Zinc 1By similarity1
Metal bindingi65Zinc 2By similarity1
Metal bindingi68Zinc 2By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei335Sequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei501SubstrateSequence analysis1
Binding sitei503SubstrateSequence analysis1
Active sitei748Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri23 – 69RING-type; degenerateAdd BLAST47

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell wall biogenesis/degradation, Cellulose biosynthesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-2364

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.1.12 399

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00695

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT2 Glycosyltransferase Family 2

Transport Classification Database

More...
TCDBi
4.D.3.1.7 the glycan glucosyl transferase (opgh) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cellulose synthase A catalytic subunit 4 [UDP-forming] (EC:2.4.1.12)
Short name:
AtCesA4
Alternative name(s):
Protein IRREGULAR XYLEM 5
Short name:
AtIRX5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CESA4
Synonyms:IRX5
Ordered Locus Names:At5g44030
ORF Names:MRH10.14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G44030

The Arabidopsis Information Resource

More...
TAIRi
locus:2172457 AT5G44030

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 215CytoplasmicSequence analysisAdd BLAST215
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Topological domaini237 – 239ExtracellularSequence analysis3
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 831CytoplasmicSequence analysisAdd BLAST571
Transmembranei832 – 852HelicalSequence analysisAdd BLAST21
Topological domaini853 – 857ExtracellularSequence analysis5
Transmembranei858 – 878HelicalSequence analysisAdd BLAST21
Topological domaini879 – 895CytoplasmicSequence analysisAdd BLAST17
Transmembranei896 – 916HelicalSequence analysisAdd BLAST21
Topological domaini917 – 945ExtracellularSequence analysisAdd BLAST29
Transmembranei946 – 966HelicalSequence analysisAdd BLAST21
Topological domaini967 – 977CytoplasmicSequence analysisAdd BLAST11
Transmembranei978 – 998HelicalSequence analysisAdd BLAST21
Topological domaini999 – 1007ExtracellularSequence analysis9
Transmembranei1008 – 1028HelicalSequence analysisAdd BLAST21
Topological domaini1029 – 1049CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Enhanced resistance to the pathogens Ralstonia solanacearum and Plectosphaerella cucumerina.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi989 – 1049Missing in irx5-2; reduced levels of crystalline cellulose in secondary cell wall, dwarf and dark green, with irregular xylems and thinner cell walls in xylem and interfascicular tissues. 1 PublicationAdd BLAST61

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001663701 – 1049Cellulose synthase A catalytic subunit 4 [UDP-forming]Add BLAST1049

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei135Phosphoserine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi921N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

S-acylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q84JA6

PRoteomics IDEntifications database

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PRIDEi
Q84JA6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q84JA6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q84JA6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Confined to secondary cell wall developing tissues such as xylems and interfascicular regions. Expressed in roots, hypocotyls, leaves, inflorescences and flowers.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Not expressed in embryos. In young leaves, localized in transient patches along the vascular system. In young inflorescence stems, observed in vascular bundles of primary xylems. In maturing inflorescence stems, most pronounced in regions of developing interfascicular fibers.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q84JA6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q84JA6 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CESA7 and CESA8. Assembly with CESA7 and CESA8 is required for functional complex and localization in secondary cell wall deposition sites.

Interacts with STL1 and STL2, but not with GOT1 (PubMed:27277162).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
19676, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q84JA6, 2 interactors

Molecular INTeraction database

More...
MINTi
Q84JA6

STRING: functional protein association networks

More...
STRINGi
3702.AT5G44030.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q84JA6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili389 – 416Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi597 – 608Cys-richAdd BLAST12
Compositional biasi616 – 644Lys-richAdd BLAST29

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri23 – 69RING-type; degenerateAdd BLAST47

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IRAS Eukaryota
COG1215 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000241942

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q84JA6

KEGG Orthology (KO)

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KOi
K10999

Database of Orthologous Groups

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OrthoDBi
679241at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q84JA6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 1 hit
3.90.550.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005150 Cellulose_synth
IPR027934 CES_Znf_RING
IPR029044 Nucleotide-diphossugar_trans
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03552 Cellulose_synt, 1 hit
PF14569 zf-UDP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q84JA6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPNTMASFD DEHRHSSFSA KICKVCGDEV KDDDNGQTFV ACHVCVYPVC
60 70 80 90 100
KPCYEYERSN GNKCCPQCNT LYKRHKGSPK IAGDEENNGP DDSDDELNIK
110 120 130 140 150
YRQDGSSIHQ NFAYGSENGD YNSKQQWRPN GRAFSSTGSV LGKDFEAERD
160 170 180 190 200
GYTDAEWKER VDKWKARQEK RGLVTKGEQT NEDKEDDEEE YLDAEARQPL
210 220 230 240 250
WRKVPISSSK ISPYRIVIVL RLVILVFFFR FRILTPAKDA YPLWLISVIC
260 270 280 290 300
EIWFALSWIL DQFPKWFPIN RETYLDRLSM RFERDGEKNK LAPVDVFVST
310 320 330 340 350
VDPLKEPPII TANTILSILA VDYPVNKVSC YVSDDGASML LFDTLSETSE
360 370 380 390 400
FARRWVPFCK KYNVEPRAPE FYFSEKIDYL KDKVQTTFVK DRRAMKREYE
410 420 430 440 450
EFKVRINALV AKAQKKPEEG WVMQDGTPWP GNNTRDHPGM IQVYLGKEGA
460 470 480 490 500
FDIDGNELPR LVYVSREKRP GYAHHKKAGA MNAMVRVSAV LTNAPFMLNL
510 520 530 540 550
DCDHYINNSK AIRESMCFLM DPQLGKKLCY VQFPQRFDGI DLNDRYANRN
560 570 580 590 600
IVFFDINMRG LDGIQGPVYV GTGCVFNRPA LYGYEPPVSE KRKKMTCDCW
610 620 630 640 650
PSWICCCCGG GNRNHKSDSS KKKSGIKSLF SKLKKKTKKK SDDKTMSSYS
660 670 680 690 700
RKRSSTEAIF DLEDIEEGLE GYDELEKSSL MSQKNFEKRF GMSPVFIAST
710 720 730 740 750
LMENGGLPEA TNTSSLIKEA IHVISCGYEE KTEWGKEIGW IYGSVTEDIL
760 770 780 790 800
TGFRMHCRGW KSVYCMPKRP AFKGSAPINL SDRLHQVLRW ALGSVEIFFS
810 820 830 840 850
RHCPLWYAWG GKLKILERLA YINTIVYPFT SIPLLAYCTI PAVCLLTGKF
860 870 880 890 900
IIPTINNFAS IWFLALFLSI IATAILELRW SGVSINDLWR NEQFWVIGGV
910 920 930 940 950
SAHLFAVFQG LLKVLFGVDT NFTVTSKGAS DEADEFGDLY LFKWTTLLIP
960 970 980 990 1000
PTTLIILNMV GVVAGVSDAI NNGYGSWGPL FGKLFFAFWV IVHLYPFLKG
1010 1020 1030 1040
LMGRQNRTPT IVVLWSILLA SIFSLVWVRI DPFLPKQTGP LLKQCGVDC
Length:1,049
Mass (Da):119,599
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6D2B1B73BBC3E41
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1R7T3H6A0A1R7T3H6_ARATH
Cellulose synthase
CESA4 cellulose synthase A4, IRREGULAR XYLEM 5, IRX5, MRH10.14, MRH10_14
1,078Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1R7T3H5A0A1R7T3H5_ARATH
Cellulose synthase A4
CESA4 cellulose synthase A4, IRREGULAR XYLEM 5, IRX5, MRH10.14, MRH10_14
770Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB09063 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti127W → C in AAO15532 (PubMed:12538856).Curated1
Sequence conflicti191Y → EL in AAO15532 (PubMed:12538856).Curated1
Sequence conflicti542L → H in AAO15532 (PubMed:12538856).Curated1
Sequence conflicti616 – 618KSD → HKSKSSDS in AAO15532 (PubMed:12538856).Curated3
Sequence conflicti630F → L in AAO15532 (PubMed:12538856).Curated1
Sequence conflicti637T → N in AAO15532 (PubMed:12538856).Curated1
Sequence conflicti655S → A in AAO15532 (PubMed:12538856).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF458083 mRNA Translation: AAO15532.1
AB006703 Genomic DNA Translation: BAB09063.1 Sequence problems.
CP002688 Genomic DNA Translation: AED95050.1
BT005710 mRNA Translation: AAO64130.1
BT006111 mRNA Translation: AAP04096.1
AK228561 mRNA Translation: BAF00480.1

NCBI Reference Sequences

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RefSeqi
NP_199216.2, NM_123770.4

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT5G44030.1; AT5G44030.1; AT5G44030

Database of genes from NCBI RefSeq genomes

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GeneIDi
834426

Gramene; a comparative resource for plants

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Gramenei
AT5G44030.1; AT5G44030.1; AT5G44030

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT5G44030

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458083 mRNA Translation: AAO15532.1
AB006703 Genomic DNA Translation: BAB09063.1 Sequence problems.
CP002688 Genomic DNA Translation: AED95050.1
BT005710 mRNA Translation: AAO64130.1
BT006111 mRNA Translation: AAP04096.1
AK228561 mRNA Translation: BAF00480.1
RefSeqiNP_199216.2, NM_123770.4

3D structure databases

SMRiQ84JA6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi19676, 7 interactors
IntActiQ84JA6, 2 interactors
MINTiQ84JA6
STRINGi3702.AT5G44030.1

Protein family/group databases

CAZyiGT2 Glycosyltransferase Family 2
TCDBi4.D.3.1.7 the glycan glucosyl transferase (opgh) family

PTM databases

iPTMnetiQ84JA6
SwissPalmiQ84JA6

Proteomic databases

PaxDbiQ84JA6
PRIDEiQ84JA6

Genome annotation databases

EnsemblPlantsiAT5G44030.1; AT5G44030.1; AT5G44030
GeneIDi834426
GrameneiAT5G44030.1; AT5G44030.1; AT5G44030
KEGGiath:AT5G44030

Organism-specific databases

AraportiAT5G44030
TAIRilocus:2172457 AT5G44030

Phylogenomic databases

eggNOGiENOG410IRAS Eukaryota
COG1215 LUCA
HOGENOMiHOG000241942
InParanoidiQ84JA6
KOiK10999
OrthoDBi679241at2759
PhylomeDBiQ84JA6

Enzyme and pathway databases

UniPathwayiUPA00695
BioCyciMetaCyc:MONOMER-2364
BRENDAi2.4.1.12 399

Miscellaneous databases

Protein Ontology

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PROi
PR:Q84JA6

Gene expression databases

ExpressionAtlasiQ84JA6 baseline and differential
GenevisibleiQ84JA6 AT

Family and domain databases

Gene3Di3.30.40.10, 1 hit
3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR005150 Cellulose_synth
IPR027934 CES_Znf_RING
IPR029044 Nucleotide-diphossugar_trans
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF03552 Cellulose_synt, 1 hit
PF14569 zf-UDP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCESA4_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q84JA6
Secondary accession number(s): Q0WQW9, Q8GZN8, Q9FNC3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2003
Last modified: December 11, 2019
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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