UniProtKB - Q84BQ9 (PRMA_THET8)
Protein
Ribosomal protein L11 methyltransferase
Gene
prmA
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Functioni
Methylates ribosomal protein L11 (PubMed:15317787). Preferentially recognizes free L11 before its incorporation into 50S subunits (PubMed:15317787). This function is dispensable for growth and thermostability (PubMed:15317787).1 Publication
Catalytic activityi
- L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteineUniRule annotation1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 107 | S-adenosyl-L-methionineUniRule annotation3 Publications | 1 | |
Binding sitei | 128 | S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation3 Publications | 1 | |
Binding sitei | 149 | S-adenosyl-L-methionineUniRule annotation3 Publications | 1 | |
Binding sitei | 175 | S-adenosyl-L-methionine3 Publications | 1 | |
Binding sitei | 191 | S-adenosyl-L-methionineUniRule annotation3 Publications | 1 |
GO - Molecular functioni
- protein methyltransferase activity Source: UniProtKB-UniRule
Keywordsi
Molecular function | Methyltransferase, Transferase |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: Ribosomal protein L11 methyltransferaseUniRule annotationCurated (EC:2.1.1.-UniRule annotation1 Publication)Short name: L11 MtaseUniRule annotationCurated |
Gene namesi | Name:prmA1 PublicationUniRule annotation Ordered Locus Names:TTHA0656 |
Organismi | Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) |
Taxonomic identifieri | 300852 [NCBI] |
Taxonomic lineagei | Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000192328 | 1 – 254 | Ribosomal protein L11 methyltransferaseAdd BLAST | 254 |
Interactioni
Binary interactionsi
Q84BQ9
With | #Exp. | IntAct |
---|---|---|
rplK [P36238] from Thermus thermophilus. | 2 | EBI-7202232,EBI-15714407 |
Protein-protein interaction databases
DIPi | DIP-44643N |
IntActi | Q84BQ9, 2 interactors |
MINTi | Q84BQ9 |
STRINGi | 300852.55772038 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q84BQ9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q84BQ9 |
Family & Domainsi
Domaini
Contains an N-terminal substrate recognition domain and a C-terminal methyltransferase domain, connected by a flexible linker.2 Publications
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG2264, Bacteria |
HOGENOMi | CLU_049382_3_1_0 |
OMAi | EFFFIFP |
PhylomeDBi | Q84BQ9 |
Family and domain databases
HAMAPi | MF_00735, Methyltr_PrmA, 1 hit |
InterProi | View protein in InterPro IPR004498, Ribosomal_PrmA_MeTrfase IPR029063, SAM-dependent_MTases |
SUPFAMi | SSF53335, SSF53335, 1 hit |
i Sequence
Sequence statusi: Complete.
Q84BQ9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWVYRLKGTL EALDPILPGL FDGGARGLWE REGEVWAFFP APVDLPYEGV
60 70 80 90 100
WEEVGDEDWL EAWRRDLKPA LAPPFVVLAP WHTWEGAEIP LVIEPGMAFG
110 120 130 140 150
TGHHETTRLA LKALARHLRP GDKVLDLGTG SGVLAIAAEK LGGKALGVDI
160 170 180 190 200
DPMVLPQAEA NAKRNGVRPR FLEGSLEAAL PFGPFDLLVA NLYAELHAAL
210 220 230 240 250
APRYREALVP GGRALLTGIL KDRAPLVREA MAGAGFRPLE EAAEGEWVLL
AYGR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 225 | P → S in BAC67244 (PubMed:12777815).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB103400 Genomic DNA Translation: BAC67244.1 AP008226 Genomic DNA Translation: BAD70479.1 |
RefSeqi | WP_011228100.1, NC_006461.1 YP_143922.1, NC_006461.1 |
Genome annotation databases
EnsemblBacteriai | BAD70479; BAD70479; BAD70479 |
GeneIDi | 3168879 |
KEGGi | ttj:TTHA0656 |
PATRICi | fig|300852.9.peg.650 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB103400 Genomic DNA Translation: BAC67244.1 AP008226 Genomic DNA Translation: BAD70479.1 |
RefSeqi | WP_011228100.1, NC_006461.1 YP_143922.1, NC_006461.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1UFK | X-ray | 1.90 | A | 1-254 | [»] | |
2NXC | X-ray | 1.59 | A | 1-254 | [»] | |
2NXE | X-ray | 1.75 | A/B | 1-254 | [»] | |
2NXJ | X-ray | 2.30 | A/B | 1-254 | [»] | |
2NXN | X-ray | 2.40 | A | 1-254 | [»] | |
2ZBP | X-ray | 2.30 | A | 1-254 | [»] | |
2ZBQ | X-ray | 2.40 | A | 1-254 | [»] | |
2ZBR | X-ray | 1.90 | A | 1-254 | [»] | |
3CJQ | X-ray | 2.70 | A/D/G | 1-254 | [»] | |
3CJR | X-ray | 2.05 | A | 1-254 | [»] | |
3CJS | X-ray | 1.37 | A | 1-59 | [»] | |
3CJT | X-ray | 2.30 | A/C/E/G/I/K/M/O | 1-254 | [»] | |
3EGV | X-ray | 1.75 | A | 1-254 | [»] | |
SMRi | Q84BQ9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-44643N |
IntActi | Q84BQ9, 2 interactors |
MINTi | Q84BQ9 |
STRINGi | 300852.55772038 |
Genome annotation databases
EnsemblBacteriai | BAD70479; BAD70479; BAD70479 |
GeneIDi | 3168879 |
KEGGi | ttj:TTHA0656 |
PATRICi | fig|300852.9.peg.650 |
Phylogenomic databases
eggNOGi | COG2264, Bacteria |
HOGENOMi | CLU_049382_3_1_0 |
OMAi | EFFFIFP |
PhylomeDBi | Q84BQ9 |
Miscellaneous databases
EvolutionaryTracei | Q84BQ9 |
Family and domain databases
HAMAPi | MF_00735, Methyltr_PrmA, 1 hit |
InterProi | View protein in InterPro IPR004498, Ribosomal_PrmA_MeTrfase IPR029063, SAM-dependent_MTases |
SUPFAMi | SSF53335, SSF53335, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRMA_THET8 | |
Accessioni | Q84BQ9Primary (citable) accession number: Q84BQ9 Secondary accession number(s): Q5SKI7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2003 |
Last sequence update: | March 29, 2005 | |
Last modified: | December 2, 2020 | |
This is version 115 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families