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Protein

DNA polymerase

Gene

POL

Organism
Orf virus (strain NZ2) (OV NZ-2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes DNA synthesis. Acquires processivity by associating with a heterodimeric processivity factor comprised of the viral A20 and D4 proteins, thereby forming the DNA polymerase holoenzyme. Displays 3'- to 5' exonuclease activity. Might participate in viral DNA recombination. Does not perform translesion synthesis across an abasic site (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication, Viral DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase (EC:2.7.7.7)
Gene namesi
Name:POL
OrganismiOrf virus (strain NZ2) (OV NZ-2)
Taxonomic identifieri10259 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeParapoxvirus
Virus hostiCapra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Ovis aries (Sheep) [TaxID: 9940]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000465361 – 1008DNA polymeraseAdd BLAST1008

Proteomic databases

PRIDEiQ84173

Interactioni

Subunit structurei

Interacts with A20. Component of the Uracil-DNA glycosylase(UDG)-A20-polymerase complex; A20 and UDG form a heterodimeric processivity factor that associates with E9 to form the processive polymerase holoenzyme (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ84173
SMRiQ84173
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.Curated

Family and domain databases

Gene3Di3.30.420.10, 1 hit
3.90.1600.10, 2 hits
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR013617 DNA-dir_DNA_pol_B_vir_insert
IPR023211 DNA_pol_palm_dom_sf
IPR013660 DNApol_B_exo_N
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF00136 DNA_pol_B, 1 hit
PF08408 DNA_pol_B_3, 1 hit
PF03104 DNA_pol_B_exo1, 1 hit
PF08452 DNAP_B_exo_N, 1 hit
PRINTSiPR00106 DNAPOLB
SMARTiView protein in SMART
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 3 hits
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

Sequencei

Sequence statusi: Complete.

Q84173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELKCLNWFE NRGNDSRFLF LKARRADNAV VYLRFVQHFY YVVRADAVAD
60 70 80 90 100
IAQPLAWTRA LGPMSVVSID EIVARSAKIP ERQRSEIELC LVASERKLAP
110 120 130 140 150
PEVFMSDFLN VSWFFVAHDI DPDGCYRVDP ALLRDLGSNC FHCDDPGACF
160 170 180 190 200
AEKIPRFNVT RSGLFLDIEC HFEKKFPSVF KNAVSHISFC VVDKDGAERR
210 220 230 240 250
FTLTNSDMLS DADLEEAARR EIPVCLDPAD VKFDAEVTLC PEVTLLRVAK
260 270 280 290 300
RLLEMPLDFV VTFNGHNFDL RYLDSRLSLL TGEHIRFRLP DGTETVNFCV
310 320 330 340 350
YERTKSSHKG VGGVSSTTFH INNNNGTIYF DLYAFIQRTE KLDSYKLDAI
360 370 380 390 400
SKNAFHCTAV VEDARPDAVR FRGDRSTDAD GNAAVFARVL STGNYVTVDE
410 420 430 440 450
RVCRVLHKRV DEDGFTVDLA DPAARAPGDR VTLAFGKDDV SLADMYANYS
460 470 480 490 500
LDVCLDMARY CLHDACLCLY LWSHYGVETK IAAAASTYLL PQSVVFEYRA
510 520 530 540 550
STCIKGPLMK LLLENRTVMV RADTKSKFFY EGGRVMAPKQ KMHNKHVLIF
560 570 580 590 600
DYNSLYPNVC IYANLSPETL VGVVVSDNRL DAEVAAVDVR RMFPAPRYIA
610 620 630 640 650
VPCEPRSPEL VAEVAIFDRE AKGIIPMLLR SFLDARAKYK KLMKAAETAV
660 670 680 690 700
DREIYNSMQY TYKITANSVY GLMGFRNSAL FSYASAKSCT AIGRTMIAYL
710 720 730 740 750
ERTLDGASVC GTRLSLAAAP DNPLLRDEAF AGRAAELEID AAVAGERTER
760 770 780 790 800
VGFRSVYGDT DSVFLEVGAS DIAFSRRVGR CLERVINEHV LFANFKVEFE
810 820 830 840 850
AVYCNLIMQS KKKYTTIKFA VSDGGGSERV SKGTSETRRD VAPFHKLMIR
860 870 880 890 900
KYKDMLCRAL AEEGSGNVGV EILRSLEDEL TFEFEARSMP LDWFLLSRTH
910 920 930 940 950
HKNFKSPDNP NVALVTRYNA ANAEAIEIGE RYFFAYVCEE GPWRRRIANV
960 970 980 990 1000
KSYERVVDKT FRLDKNERIM YEVYFKRLCT EIVNLLDNKA MCTLFFERLF

GSKPVFTG
Length:1,008
Mass (Da):113,955
Last modified:November 1, 1996 - v1
Checksum:i3C9A0450DA1990D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49979 Genomic DNA Translation: AAB19092.1

Similar proteinsi

Entry informationi

Entry nameiDPOL_ORFN2
AccessioniPrimary (citable) accession number: Q84173
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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