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UniProtKB - Q83RQ0 (EMTAL_SHIFL)
Protein
Endo-type membrane-bound lytic murein transglycosylase A-like protein
Gene
emtA2
Organism
Shigella flexneri
Status
Functioni
Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division (Potential).
CuratedCatalytic activityi
- Endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.UniRule annotation EC:4.2.2.n2
GO - Molecular functioni
- carbon-oxygen lyase activity, acting on polysaccharides Source: UniProtKB-UniRule
- lytic endotransglycosylase activity Source: InterPro
GO - Biological processi
- cell wall macromolecule catabolic process Source: UniProtKB-UniRule
- cell wall organization Source: UniProtKB-KW
- peptidoglycan metabolic process Source: InterPro
Keywordsi
Molecular function | Lyase |
Biological process | Cell wall biogenesis/degradation |
Names & Taxonomyi
Protein namesi | Recommended name: Endo-type membrane-bound lytic murein transglycosylase A-like proteinUniRule annotation (EC:4.2.2.n2UniRule annotation)Alternative name(s): Peptidoglycan lytic endotransglycosylaseUniRule annotation |
Gene namesi | Name:emtA2UniRule annotation Synonyms:mltE Ordered Locus Names:SF1183 |
Organismi | Shigella flexneri |
Taxonomic identifieri | 623 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Shigella |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000312917 | 1 – 219 | Endo-type membrane-bound lytic murein transglycosylase A-like proteinAdd BLAST | 219 |
Family & Domainsi
Sequence similaritiesi
Belongs to the transglycosylase Slt family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_103257_0_0_6 |
Family and domain databases
HAMAPi | MF_01381, EmtA, 1 hit |
InterProi | View protein in InterPro IPR023946, EmtA IPR023346, Lysozyme-like_dom_sf IPR000189, Transglyc_AS IPR008258, Transglycosylase_SLT_dom_1 |
Pfami | View protein in Pfam PF01464, SLT, 1 hit |
SUPFAMi | SSF53955, SSF53955, 1 hit |
PROSITEi | View protein in PROSITE PS00922, TRANSGLYCOSYLASE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q83RQ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPVVTLTGIP GYTGLRIEID MVCLFDWLLA GCSSKHDYTN PPWNAKVPVQ
60 70 80 90 100
RAMQWMPISQ KAGAAWGVDP QLITAIIAIE SGGNPNAVSK SNAIGLMQLK
110 120 130 140 150
ASTSGRDVYR RMGWSGEPTT SELKNPERNI SMGAAYLNIL ETGPLAGIED
160 170 180 190 200
PKVLQYALVV SYANGAGALL RTFSSDRKKA ISKINDLDAD EFLDHVARNH
210
PAPQAPRYIY KLEQALDAM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005674 Genomic DNA Translation: AAN42798.1 |
RefSeqi | NP_707091.1, NC_004337.2 |
Genome annotation databases
EnsemblBacteriai | AAN42798; AAN42798; SF1183 |
GeneIDi | 1024114 |
KEGGi | sfl:SF1183 |
PATRICi | fig|198214.7.peg.1398 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005674 Genomic DNA Translation: AAN42798.1 |
RefSeqi | NP_707091.1, NC_004337.2 |
3D structure databases
AlphaFoldDBi | Q83RQ0 |
SMRi | Q83RQ0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 198214.SF1183 |
Genome annotation databases
EnsemblBacteriai | AAN42798; AAN42798; SF1183 |
GeneIDi | 1024114 |
KEGGi | sfl:SF1183 |
PATRICi | fig|198214.7.peg.1398 |
Phylogenomic databases
HOGENOMi | CLU_103257_0_0_6 |
Family and domain databases
HAMAPi | MF_01381, EmtA, 1 hit |
InterProi | View protein in InterPro IPR023946, EmtA IPR023346, Lysozyme-like_dom_sf IPR000189, Transglyc_AS IPR008258, Transglycosylase_SLT_dom_1 |
Pfami | View protein in Pfam PF01464, SLT, 1 hit |
SUPFAMi | SSF53955, SSF53955, 1 hit |
PROSITEi | View protein in PROSITE PS00922, TRANSGLYCOSYLASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EMTAL_SHIFL | |
Accessioni | Q83RQ0Primary (citable) accession number: Q83RQ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | June 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families