UniProtKB - Q83QT2 (NUON_SHIFL)
Protein
NADH-quinone oxidoreductase subunit N
Gene
nuoN
Organism
Shigella flexneri
Status
Functioni
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation
Catalytic activityi
GO - Molecular functioni
- NADH dehydrogenase (ubiquinone) activity Source: InterPro
- quinone binding Source: UniProtKB-KW
GO - Biological processi
- ATP synthesis coupled electron transport Source: InterPro
Keywordsi
Molecular function | Translocase |
Biological process | Transport |
Ligand | NAD, Ubiquinone |
Names & Taxonomyi
Protein namesi | Recommended name: NADH-quinone oxidoreductase subunit NUniRule annotation (EC:7.1.1.-UniRule annotation)Alternative name(s): NADH dehydrogenase I subunit NUniRule annotation NDH-1 subunit NUniRule annotation |
Gene namesi | Name:nuoNUniRule annotation Ordered Locus Names:SF2352, S2487 |
Organismi | Shigella flexneri |
Taxonomic identifieri | 623 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Shigella |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 8 – 28 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 35 – 55 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 71 – 91 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 105 – 125 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 127 – 147 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 159 – 179 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 203 – 223 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 235 – 255 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 271 – 291 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 297 – 317 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 326 – 346 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 373 – 393 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 408 – 430 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 455 – 475 | HelicalUniRule annotationAdd BLAST | 21 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000249451 | 1 – 485 | NADH-quinone oxidoreductase subunit NAdd BLAST | 485 |
Keywords - PTMi
QuinoneInteractioni
Subunit structurei
NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Belongs to the complex I subunit 2 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4105CNR Bacteria COG1007 LUCA |
HOGENOMi | HOG000100796 |
KOi | K00343 |
OrthoDBi | 1664448at2 |
Family and domain databases
HAMAPi | MF_00445 NDH1_NuoN_1, 1 hit |
InterProi | View protein in InterPro IPR010096 NADH-Q_OxRdtase_suN/2 IPR001750 ND/Mrp_mem |
Pfami | View protein in Pfam PF00361 Proton_antipo_M, 1 hit |
TIGRFAMsi | TIGR01770 NDH_I_N, 1 hit |
i Sequence
Sequence statusi: Complete.
Q83QT2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTITPQNLIA LLPLLIVGLT VVVVMLSIAW RRNHFLNATL SVIGLNAALV
60 70 80 90 100
SLWFVGQAGA MDVTPLMRVD GFAMLYTGLV LLASLATCTF AYPWLEGYND
110 120 130 140 150
NKDEFYLLVL IAALGGILLA NANHLASLFL GIELISLPLF GLVGYAFRQK
160 170 180 190 200
RSLEASIKYT ILSAAASSFL LFGMALVYAQ SGDLSFVALG KNLGDGMLNE
210 220 230 240 250
PLLLAGFGMM IVGLGFKLSL VPFHLWTPDV YQGAPAPVST FLATASKIAI
260 270 280 290 300
FGVVMRLFLY APVGDSEAIR VVLAIIAFAS IIFGNLMALS QTNIKRLLGY
310 320 330 340 350
SSISHLGYLL VALIALQTGE MSMEAVGVYL AGYLFSSLGA FGVVSLMSSP
360 370 380 390 400
YRGPDADSLF SYRGLFWHRP ILAAVMTVMM LSLAGIPMTL GFIGKFYVLA
410 420 430 440 450
VGVQAHLWWL VGAVVVGSAI GLYYYLRVAV SLYLHAPEQP GRDAPSNWQY
460 470 480
SAGGIVVLIS ALLVLVLGVW PQPLISIVRL AMPLM
Sequence cautioni
The sequence AAN43865 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP17683 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005674 Genomic DNA Translation: AAN43865.2 Different initiation. AE014073 Genomic DNA Translation: AAP17683.1 Different initiation. |
RefSeqi | NP_708158.4, NC_004337.2 WP_000156718.1, NZ_UIQL01000008.1 |
Genome annotation databases
EnsemblBacteriai | AAN43865; AAN43865; SF2352 AAP17683; AAP17683; S2487 |
GeneIDi | 1027239 |
KEGGi | sfl:SF2352 sfx:S2487 |
PATRICi | fig|198214.7.peg.2818 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE005674 Genomic DNA Translation: AAN43865.2 Different initiation. AE014073 Genomic DNA Translation: AAP17683.1 Different initiation. |
RefSeqi | NP_708158.4, NC_004337.2 WP_000156718.1, NZ_UIQL01000008.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
EnsemblBacteriai | AAN43865; AAN43865; SF2352 AAP17683; AAP17683; S2487 |
GeneIDi | 1027239 |
KEGGi | sfl:SF2352 sfx:S2487 |
PATRICi | fig|198214.7.peg.2818 |
Phylogenomic databases
eggNOGi | ENOG4105CNR Bacteria COG1007 LUCA |
HOGENOMi | HOG000100796 |
KOi | K00343 |
OrthoDBi | 1664448at2 |
Family and domain databases
HAMAPi | MF_00445 NDH1_NuoN_1, 1 hit |
InterProi | View protein in InterPro IPR010096 NADH-Q_OxRdtase_suN/2 IPR001750 ND/Mrp_mem |
Pfami | View protein in Pfam PF00361 Proton_antipo_M, 1 hit |
TIGRFAMsi | TIGR01770 NDH_I_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NUON_SHIFL | |
Accessioni | Q83QT2Primary (citable) accession number: Q83QT2 Secondary accession number(s): Q7UC57 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2006 |
Last sequence update: | September 19, 2006 | |
Last modified: | September 18, 2019 | |
This is version 110 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families