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Protein

Ribosomal RNA large subunit methyltransferase I

Gene

rlmI

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytosine(1962) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(1962) in 23S rRNA.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase IUniRule annotation (EC:2.1.1.191UniRule annotation)
Alternative name(s):
23S rRNA m5C1962 methyltransferaseUniRule annotation
rRNA (cytosine-C(5)-)-methyltransferase RlmIUniRule annotation
Gene namesi
Name:rlmIUniRule annotation
Ordered Locus Names:SF0970, S1035
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003662691 – 396Ribosomal RNA large subunit methyltransferase IAdd BLAST396

Proteomic databases

PRIDEiQ83LM0

Structurei

3D structure databases

ProteinModelPortaliQ83LM0
SMRiQ83LM0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 81PUAUniRule annotationAdd BLAST80

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RlmI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DR4 Bacteria
COG1092 LUCA
HOGENOMiHOG000266009
KOiK06969
OMAiGRYPFGH

Family and domain databases

Gene3Di2.30.130.10, 1 hit
HAMAPiMF_01857 23SrRNA_methyltr_I, 1 hit
InterProiView protein in InterPro
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
IPR023542 rRNA_lsu_MeTfrase_I
IPR019614 SAM-dep_methyl-trfase
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF10672 Methyltrans_SAM, 1 hit
SMARTiView protein in SMART
SM00359 PUA, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
SSF88697 SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS50890 PUA, 1 hit

Sequencei

Sequence statusi: Complete.

Q83LM0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVRLVLAKG REKSLLRRHP WVFSGAVARM EGKASLGETI DIVDHQGKWL
60 70 80 90 100
ARGAYSPASQ IRARVWTFDP SESIDIAFFS RRLQQAQKWR DWLAQKDGLD
110 120 130 140 150
SYRLIAGESD GLPGITIDRF GNFLVLQLLS AGAEYQRAAL ITALQTLYPE
160 170 180 190 200
CAIYDRSDVA VRKKEGMELT HGLLTGELPP ALLPIEEHGM NLLVDIHHGH
210 220 230 240 250
KTAYYLDQRD SRLATRRYVE NKRVLNCFSY TGGFAVSALM GGCSQVVSVD
260 270 280 290 300
TSQEALDIAR QNVELNKLDL SKAEFVRDDV FKLLRTYRDR GEKFDVIVMD
310 320 330 340 350
PPKFVENKSQ LMGACRGYKD INMLAIQLLN EGGILLTFSC SGLMTSDLFQ
360 370 380 390
KIIADAAIDA GRDVQFIEQF RQAADHPVIA TYPEGLYLKG FACRVM
Length:396
Mass (Da):44,403
Last modified:June 1, 2003 - v1
Checksum:iCBE94EDB7E5B7769
GO

Sequence cautioni

The sequence AAP16483 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142T → S in AAP16483 (PubMed:12704152).Curated1
Sequence conflicti171H → Q in AAP16483 (PubMed:12704152).Curated1
Sequence conflicti174L → V in AAP16483 (PubMed:12704152).Curated1
Sequence conflicti191N → K in AAP16483 (PubMed:12704152).Curated1
Sequence conflicti197H → Q in AAP16483 (PubMed:12704152).Curated1
Sequence conflicti203A → G in AAP16483 (PubMed:12704152).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA Translation: AAN42597.1
AE014073 Genomic DNA Translation: AAP16483.1 Different initiation.
RefSeqiNP_706890.1, NC_004337.2

Genome annotation databases

EnsemblBacteriaiAAN42597; AAN42597; SF0970
AAP16483; AAP16483; S1035
GeneIDi1023901
KEGGisfl:SF0970
sfx:S1035
PATRICifig|198214.7.peg.1128

Similar proteinsi

Entry informationi

Entry nameiRLMI_SHIFL
AccessioniPrimary (citable) accession number: Q83LM0
Secondary accession number(s): Q7UD12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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