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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 3 Mg2+ ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi409Magnesium 1UniRule annotation1
Metal bindingi416Magnesium 1UniRule annotation1
Metal bindingi416Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR227377:G1G0B-426-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
Alternative name(s):
Lysyl-tRNA synthetaseUniRule annotation
Short name:
LysRSUniRule annotation
Gene namesi
Name:lysSUniRule annotation
Ordered Locus Names:CBU_0430
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001526201 – 498Lysine--tRNA ligaseAdd BLAST498

Proteomic databases

PRIDEiQ83E97

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_0430

Structurei

3D structure databases

ProteinModelPortaliQ83E97
SMRiQ83E97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CRK Bacteria
COG1190 LUCA
HOGENOMiHOG000236578
KOiK04567
OMAiMMNIIPG

Family and domain databases

CDDicd00775 LysRS_core, 1 hit
HAMAPiMF_00252 Lys_tRNA_synth_class2, 1 hit
InterProiView protein in InterPro
IPR004364 aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR002313 Lys-tRNA-ligase_II
IPR018149 Lys-tRNA-synth_II_C
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
PfamiView protein in Pfam
PF00152 tRNA-synt_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
PRINTSiPR00982 TRNASYNTHLYS
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00499 lysS_bact, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

Q83E97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELKDQIKEE NEQIAQRKLK LKKRREEGQA YPNDFKRDSL AADLHAVYDQ
60 70 80 90 100
FDSGALTAKA IRVKMAGRMM TRRIMGKASF AHIQDMKGRM QIYVTRDSLP
110 120 130 140 150
QGVYSDFKSW DLGDIVGIEG ELFKTKTEEL SVKVDQIRLL TKALRPMPDK
160 170 180 190 200
FHGLHDQEQR FRQRYLDLIV NESSRHLFQT RSQVIAQIRR FLDDRGYIEV
210 220 230 240 250
ETPMMHPLPG GAAARPFETH HNAMNMDLFL RIAPELYLKR LVVGGFEKVY
260 270 280 290 300
EINRNFRNEG ISTRHNPEFT MLEFYQAYAT YEDMMMLTES MIRHLAEKIF
310 320 330 340 350
GVMEIKYQGV RIDLNKPFPR LSLRDAILQF NPGITPDQID HLETARELAH
360 370 380 390 400
KYEIATPAHY GLGKIQTELF EKLVEEKLQQ PIFITHFPKE VSPLSRANEE
410 420 430 440 450
NDFITDRFEF YVGGREIANG FSELNDPEDQ AARFREQLKA RNAGDLEAMS
460 470 480 490
FDEDYITALE YGLPPTAGEG IGIDRLVMLF TDNASIRDVI LFPLLRSK
Length:498
Mass (Da):57,739
Last modified:June 1, 2003 - v1
Checksum:i8092BC68989DAC00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA Translation: AAO89981.1
RefSeqiNP_819467.1, NC_002971.3
WP_005771651.1, NZ_LM994641.1

Genome annotation databases

EnsemblBacteriaiAAO89981; AAO89981; CBU_0430
GeneIDi1208314
31484251
KEGGicbu:CBU_0430
PATRICifig|227377.7.peg.419

Similar proteinsi

Entry informationi

Entry nameiSYK_COXBU
AccessioniPrimary (citable) accession number: Q83E97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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