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Protein

Alanine racemase

Gene

alr

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei34Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei129SubstrateUniRule annotation1
Active sitei259Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei307Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciCBUR227377:G1G0B-861-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Ordered Locus Names:CBU_0869
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000659851 – 364Alanine racemaseAdd BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ83D71

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_0869

Structurei

3D structure databases

ProteinModelPortaliQ83D71
SMRiQ83D71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031446
KOiK01775
OMAiWEILCGF

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit

Sequencei

Sequence statusi: Complete.

Q83D71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRATATINV TALKHNLSQI KALAPKSLAW AMIKSNGYGH GLVRVAKALS
60 70 80 90 100
DANAFGVACI DEALTLREVG IKSPIIVMKG FYNEAELSQF ARHRLGAVIH
110 120 130 140 150
CSDQVSLLEK TNLTSSLSVW LKIDTGMNRL GFSVEQSPAV YNQLKTSSSI
160 170 180 190 200
QKPIGLMTHL ADADNENKTF TELQIKRFFS VTEKMIGPKS IVNSAGFFAY
210 220 230 240 250
PNALVDWIRP GIILYGISPF GINYNSFKEK IEKKFRPVMT LSAKIIAIKN
260 270 280 290 300
RRQNDSVGYG CTWSCPEDMP IAIVSIGYGD GYPRHAPSGT PVLLNGKICP
310 320 330 340 350
LIGRVSMDMI AIDLRSQPNA QVGDDVILWG EGLPVEIIAE KAGTIAYELL
360
CKITQRVQFI EIEK
Length:364
Mass (Da):39,962
Last modified:June 1, 2003 - v1
Checksum:i38DD172C79E0E8DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA Translation: AAO90402.1
RefSeqiNP_819888.1, NC_002971.3
WP_005772336.1, NC_002971.4

Genome annotation databases

EnsemblBacteriaiAAO90402; AAO90402; CBU_0869
GeneIDi1208762
KEGGicbu:CBU_0869
PATRICifig|227377.7.peg.854

Similar proteinsi

Entry informationi

Entry nameiALR_COXBU
AccessioniPrimary (citable) accession number: Q83D71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: February 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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