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Protein

Ribosomal RNA large subunit methyltransferase E

Gene

rlmE

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine(2552) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei59S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei77S-adenosyl-L-methionineUniRule annotation1
Binding sitei93S-adenosyl-L-methionineUniRule annotation1
Binding sitei122S-adenosyl-L-methionineUniRule annotation1
Active sitei162Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCBUR227377:G1G0B-1341-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase EUniRule annotation (EC:2.1.1.166UniRule annotation)
Alternative name(s):
23S rRNA Um2552 methyltransferaseUniRule annotation
rRNA (uridine-2'-O-)-methyltransferaseUniRule annotation
Gene namesi
Name:rlmEUniRule annotation
Synonyms:ftsJUniRule annotation, rrmJUniRule annotation
Ordered Locus Names:CBU_1353
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001554891 – 212Ribosomal RNA large subunit methyltransferase EAdd BLAST212

Proteomic databases

PRIDEiQ83BY4

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_1353

Structurei

3D structure databases

ProteinModelPortaliQ83BY4
SMRiQ83BY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F7M Bacteria
COG0293 LUCA
HOGENOMiHOG000162366
KOiK02427
OMAiHRQTDHL

Family and domain databases

HAMAPiMF_01547 RNA_methyltr_E, 1 hit
InterProiView protein in InterPro
IPR015507 rRNA-MeTfrase_E
IPR002877 rRNA_MeTrfase_FtsJ_dom
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF01728 FtsJ, 1 hit
PIRSFiPIRSF005461 23S_rRNA_mtase, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

Sequencei

Sequence statusi: Complete.

Q83BY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHSKRWLEE HEKDPYVKRA KKEGYPSRAA YKLLEIHQKY KLFKPSMNVI
60 70 80 90 100
DLGAAPGGWS QVAKDLVGPK GVVIAIDLLP MQSMLDVIFI QGDFNEPEIF
110 120 130 140 150
NQLEAIVAKK TLTGQVDLVI SDMAPNISGI KNVDQSRSLH LVELAWDCAQ
160 170 180 190 200
KLLARGGTFL VKVFQGPGVD RFLINLRPYF NQVKFLKPSA SRSRSSEIYI
210
LAGEFLGYNQ RV
Length:212
Mass (Da):23,862
Last modified:June 1, 2003 - v1
Checksum:iD5E1DD704C8FE8B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA Translation: AAO90856.1
RefSeqiNP_820342.1, NC_002971.3
WP_010958173.1, NZ_LM994641.1

Genome annotation databases

EnsemblBacteriaiAAO90856; AAO90856; CBU_1353
GeneIDi1209259
31484051
KEGGicbu:CBU_1353
PATRICifig|227377.7.peg.1348

Similar proteinsi

Entry informationi

Entry nameiRLME_COXBU
AccessioniPrimary (citable) accession number: Q83BY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: February 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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