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Protein

Cystathionine beta-lyase

Gene

metC

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of cystathionine to homocysteine, pyruvate and ammonia during methionine biosynthesis.By similarity

Catalytic activityi

L-cystathionine + H2O = L-homocysteine + NH3 + pyruvate.By similarity

Cofactori

pyridoxal 5'-phosphateBy similarity

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from L-cystathionine.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Cystathionine beta-lyase (metC)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from L-cystathionine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • methionine biosynthetic process Source: TIGR

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Methionine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciCBUR227377:G1G0B-1997-MONOMER
UniPathwayiUPA00051; UER00078

Names & Taxonomyi

Protein namesi
Recommended name:
Cystathionine beta-lyase (EC:4.4.1.8By similarity)
Short name:
CBL
Alternative name(s):
Beta-cystathionase
Cysteine lyase
Gene namesi
Name:metC
Ordered Locus Names:CBU_2025
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003205791 – 387Cystathionine beta-lyaseAdd BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei204N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiQ83A83

Expressioni

Developmental stagei

More than twofold more abundant in the small cell variant (SCV) stage than in the large cell variant (LCV) stage (at protein level). LCVs are more metabolically active than SCVs.1 Publication

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi227377.CBU_2025

Structurei

3D structure databases

ProteinModelPortaliQ83A83
SMRiQ83A83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the trans-sulfuration enzymes family.Curated

Phylogenomic databases

eggNOGiENOG4105C28 Bacteria
COG0626 LUCA
HOGENOMiHOG000246415
KOiK01760
OMAiMQTKLIH

Family and domain databases

CDDicd00614 CGS_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR000277 Cys/Met-Metab_PyrdxlP-dep_enz
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11808 PTHR11808, 1 hit
PfamiView protein in Pfam
PF01053 Cys_Met_Meta_PP, 1 hit
PIRSFiPIRSF001434 CGS, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00868 CYS_MET_METAB_PP, 1 hit

Sequencei

Sequence statusi: Complete.

Q83A83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTANNNKKSH IDTRVIHAGQ KPDPLTGAVM TPIYTASTYA QKSPGVHQGY
60 70 80 90 100
EYSRSQNPTR FAYERCVADL ESGQHGFAFA SGMAATATIL ELLQPGDHVV
110 120 130 140 150
VMDDVYGGSY RLFENVRKRS AGLSFSFVDF TDENKVREAV TAKTKMLWVE
160 170 180 190 200
SPSNPRLKIV DLAKIAEIAK EKNIIAVADN TFATPIIQRP LELGFDIVTH
210 220 230 240 250
SATKYLNGHS DIIGGVAVVG DNKTLAEQLK YLQNAIGAIA APFDSFMVLR
260 270 280 290 300
GLKTLAIRME RHCENAMQLA QWLEKHPKVK RVYYPGLPSH PQHSIAKKQM
310 320 330 340 350
RYFGGMISVE LKCDLNETKK VLERCQLFTL AESLGGVESL IEHPAIMTHA
360 370 380
SIPQAERQKL GITDGFIRLS VGIEAITDLR HDLEAAL
Length:387
Mass (Da):42,776
Last modified:June 1, 2003 - v1
Checksum:i6DF7959AA345B6AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA Translation: AAO91512.1
RefSeqiNP_820998.1, NC_002971.3
WP_010958610.1, NZ_LM994641.1

Genome annotation databases

EnsemblBacteriaiAAO91512; AAO91512; CBU_2025
GeneIDi1209938
KEGGicbu:CBU_2025
PATRICifig|227377.7.peg.2017

Similar proteinsi

Entry informationi

Entry nameiMETC_COXBU
AccessioniPrimary (citable) accession number: Q83A83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: February 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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