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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase small chain (carA)
  2. Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

BioCyciCBUR227377:G1G0B-2059-MONOMER
UniPathwayiUPA00070; UER00116

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Short name:
ATCaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotation
Ordered Locus Names:CBU_2095
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001131241 – 310Aspartate carbamoyltransferaseAdd BLAST310

Proteomic databases

PRIDEiQ83A16

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_2095

Structurei

3D structure databases

ProteinModelPortaliQ83A16
SMRiQ83A16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXT Bacteria
COG0540 LUCA
HOGENOMiHOG000022685
KOiK00609
OMAiWCDVANM

Family and domain databases

Gene3Di3.40.50.1370, 3 hits
HAMAPiMF_00001 Asp_carb_tr, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR002082 Asp_carbamoyltransf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
PANTHERiPTHR11405:SF16 PTHR11405:SF16, 1 hit
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00101 ATCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00670 asp_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q83A16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNELPLHLLN MRSLTRDHIE KLIQRANYFL TQGMEKNSVF ETLKGHVVAN
60 70 80 90 100
LFFEPSTRTR NSFEIAAKRL GAMVLNPNLK ISAISKGETL FDTIKTLEAM
110 120 130 140 150
GVYFFIVRHS ENETPEQIAK QLSSGVVINA GDGNHQHPSQ ALIDLMTIKQ
160 170 180 190 200
HKPHWNKLCV TIIGDIRHSR VANSLMDGLV TMGVPEIRLV GPSSLLPDKV
210 220 230 240 250
GNDSIKKFTE LKPSLLNSDV IVTLRLQKER HDNSVDIDAF RGSFRLTPEK
260 270 280 290 300
LYSAKPDAIV MHPGPVNREV EINSDVADNQ QSVILQQVRN GVAMRMAVLE
310
LFLLRDFRFF
Length:310
Mass (Da):34,944
Last modified:June 1, 2003 - v1
Checksum:i1900658F558E5A5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA Translation: AAO91579.1
RefSeqiNP_821065.1, NC_002971.3
WP_010958650.1, NZ_LM994641.1

Genome annotation databases

EnsemblBacteriaiAAO91579; AAO91579; CBU_2095
GeneIDi1210008
31484771
KEGGicbu:CBU_2095
PATRICifig|227377.7.peg.2086

Similar proteinsi

Entry informationi

Entry nameiPYRB_COXBU
AccessioniPrimary (citable) accession number: Q83A16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: February 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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