UniProtKB - Q83045 (R1AB_LIYV9)
Protein
Replicase polyprotein 1ab
Gene
N/A
Organism
Lettuce infectious yellows virus (isolate United States/92) (LIYV)
Status
Functioni
RNA-dependent RNA polymerase replicates the viral genome composed of 2 RNA segments, RNA1 and RNA2.Curated
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 344 | For leader protease activityBy similarity | 1 | |
Active sitei | 393 | For leader protease activityBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cysteine-type peptidase activity Source: UniProtKB-KW
- mRNA methyltransferase activity Source: InterPro
- RNA binding Source: InterPro
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
- RNA helicase activity Source: UniProtKB-EC
GO - Biological processi
- RNA processing Source: InterPro
- transcription, DNA-templated Source: InterPro
- viral RNA genome replication Source: InterPro
Keywordsi
Molecular function | Helicase, Hydrolase, Methyltransferase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase |
Biological process | Viral RNA replication |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Replicase polyprotein 1abCleaved into the following 2 chains: |
Organismi | Lettuce infectious yellows virus (isolate United States/92) (LIYV) |
Taxonomic identifieri | 651355 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Kitrinoviricota › Alsuviricetes › Martellivirales › Closteroviridae › Crinivirus › |
Virus hosti | Beta vulgaris (Sugar beet) [TaxID: 161934] Citrullus lanatus (Watermelon) (Citrullus vulgaris) [TaxID: 3654] Cucumis melo (Muskmelon) [TaxID: 3656] Cucurbita maxima (Pumpkin) (Winter squash) [TaxID: 3661] Cucurbita moschata (Winter crookneck squash) (Cucurbita pepo var. moschata) [TaxID: 3662] Cucurbita pepo (Vegetable marrow) (Summer squash) [TaxID: 3663] Daucus carota (Wild carrot) [TaxID: 4039] Lactuca sativa (Garden lettuce) [TaxID: 4236] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000402510 | 1 – 2379 | Replicase polyprotein 1abAdd BLAST | 2379 | |
ChainiPRO_0000402511 | 1 – 413 | Leader proteaseBy similarityAdd BLAST | 413 | |
ChainiPRO_0000402512 | 414 – 2379 | Methyltransferase/helicase/RNA-directed RNA polymeraseBy similarityAdd BLAST | 1966 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 413 – 414 | Cleavage; by the leader proteaseBy similarity | 2 |
Proteomic databases
PRIDEi | Q83045 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 495 – 674 | Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST | 180 | |
Domaini | 1538 – 1705 | (+)RNA virus helicase ATP-bindingAdd BLAST | 168 | |
Domaini | 1706 – 1874 | (+)RNA virus helicase C-terminalAdd BLAST | 169 | |
Domaini | 2138 – 2251 | RdRp catalyticPROSITE-ProRule annotationAdd BLAST | 114 |
Domaini
The C-terminal domain is required for autoproteolysis.By similarity
Sequence similaritiesi
Belongs to the ssRNA positive-strand viruses RNA-directed RNA polymerase family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR002588, Alphavirus-like_MT_dom IPR043502, DNA/RNA_pol_sf IPR027417, P-loop_NTPase IPR007094, RNA-dir_pol_PSvirus IPR001788, Tymovirus_RNA-dep_RNA_pol |
Pfami | View protein in Pfam PF00978, RdRP_2, 1 hit PF01443, Viral_helicase1, 1 hit PF01660, Vmethyltransf, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51743, ALPHAVIRUS_MT, 1 hit PS51657, PSRV_HELICASE, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsiribosomal frameshifting. AlignAdd to basketNote: The replicase 1a is produced from conventional translation of the 1a ORF. The replicase 1ab is generated probably by a +1 ribosomal frameshifting mechanism occurring at the 1a-1b genes boundary.
Isoform Replicase 1ab (identifier: Q83045-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALEVESAFS LSYLLKENKQ TSNNLFSLIQ VPYTKMTHAK GKKTHLLRCI
60 70 80 90 100
LGSPFETLTK SSIRRSLKNL REVCNLPYCN FKKIPKNISY KYQNPFLKLY
110 120 130 140 150
EINNNFINCK VGATGNTNST YDWRNLSTIG NGWSVTSYHN DSVSRLHVSM
160 170 180 190 200
VNNIPNSNTK KLSWWVTRVR SKNPWKRPYK VIYQRDFRDD GIKPYVSEFI
210 220 230 240 250
LYAPKNRADL EMQSILLSSV ECFQDIKYAL NYWTNLKFKE ICNSALKRFT
260 270 280 290 300
QTNIIITPVK PRVVSVNKAR EVSSSVEVKL QRYEREGEVF VVSKAGKEDT
310 320 330 340 350
RVLNDDNAIR NLFNATLNGG KYKLHPEAKS ATGKRFKYYK DGFCWLDVFA
360 370 380 390 400
DANRRIPEWV KPHCLLTGSV LMSCGLWDFA KRKMVSVSHG LLHYDRKLER
410 420 430 440 450
SSARAGVRDF VGASNEAVQR EDFRDLDLRV EEFAERVLET ANLRSDNRLI
460 470 480 490 500
DNILTRASDY INKKSKESKE LDINVCLSMD EKKMITNLFP DIQMSFNQKS
510 520 530 540 550
YSNHGVFNAM RACENFYFSR KFKNSDYIDA GGDVVSTLRS KNHNVHICSP
560 570 580 590 600
RLDLKDAARH IQRATVIDGL KGYGETISFC TNKTEDCAVN RDIIIAVEVY
610 620 630 640 650
DMTLRDMAKA MLSHGSRKFE FSCIIPPEIF TKECNVELYE GRLKVTRIGD
660 670 680 690 700
NVEYYYGSNG ETFSHSCQTL KDILSVQVFQ FGGRVFKKTL EHSRGQLHFF
710 720 730 740 750
SICICEKIEP GSVKLKTYYQ RSELDKVTLR IPVKDSFGVV THYIIKEDRE
760 770 780 790 800
FVSSMIEYVA NTGIKIDDKM VEWTYSQYRA KKTVTIKSGK VTQKETRIRK
810 820 830 840 850
ELIPGFIAII MSEGIRAREK THYLAKMLYT SHYKPSIVNI IFRLIMHFLG
860 870 880 890 900
GTKRFIYESL VDCLKFLTNS DYIDTIVNTE SRIEDLDKWF VFEQNVTITT
910 920 930 940 950
DAEDQPSILE QSVKTFLSKY SEDVYERGDR SEFELEEFSS EQDLVDQLLN
960 970 980 990 1000
SGGGSKEDEW FYSYIFSIVR TKCTLSLAWR WTNRIFNFIT SCRAKGKDFV
1010 1020 1030 1040 1050
KYIYEIIKII INKPWEALCH YLVQGYKTVL KIPMTCVDSV NYLKRKSLEK
1060 1070 1080 1090 1100
ILSYFSHERA DDEYIFPGYD SDFSEESGDY GDENTELDSR SRCTVIKSKV
1110 1120 1130 1140 1150
EMLFRNIKGH IEKFLQRCGI IDQYNKIYHW FKSILTDVDC FNSVLNFITH
1160 1170 1180 1190 1200
TGCDALLAVL TGHFSIASCA LKFMTDVVIE KNLSEKHHTT TKLIAGNLTQ
1210 1220 1230 1240 1250
CIYKLDFIHP IWIPIRWGVK EISKIHIKKK LLNWRSTKEV TNESICKDLV
1260 1270 1280 1290 1300
HKSYIKYFDI KKAVWLLWFS LLIIFLHPTL GFFILFSIYP AIEIKRYYNN
1310 1320 1330 1340 1350
VVCFNNIKMS YPHVIDRLGG TYNFAKLKKA VREKFSENKS QGVKISEIPA
1360 1370 1380 1390 1400
EKDEDVMPPL EEVETPKRSV GRPSSKQDDI EDECNIKEDP TESLNFSNIE
1410 1420 1430 1440 1450
ATSNRYDTLR VGNSKLCKFL RFYPKSKCYA NIQTGDLIRD SIEEFYHLER
1460 1470 1480 1490 1500
SKLDIEISKM QRVVEIMNDT GRMLDNVRRM IDDRSMYVTL DGVSWYRLGC
1510 1520 1530 1540 1550
KDKNPAKEDF KAIFDHNFNI MEGNAKVKEF AVSSDEWRGM YSNERCRAIE
1560 1570 1580 1590 1600
QLFNDNNEMV RRPDVNGLKF YNKPPGAGKT TTIAKLMSKD LKNKVKCLAL
1610 1620 1630 1640 1650
SYTKVGRLEL IDKLKKDGIE KPEKYVKTYD SFLMNNDNIL EIVNLYCDEV
1660 1670 1680 1690 1700
FMMHAGHFLT LLTKIAYQNG YCYGDVNQIP FINRDPYTPA YLSREFFRKQ
1710 1720 1730 1740 1750
DLNYDTYTYR CPLDTCYLLS NLKDEMGNII YAGGVKNVNE VYPTIRSLNL
1760 1770 1780 1790 1800
FGINVVGEVP VEYNAKYLTF TQDEKLNLQR HIDSQGGCRN AVSTVNEAQG
1810 1820 1830 1840 1850
CTFSEVNLVR LVQFDNPVMS DINQFVVAIS RHTTTFKYFT PHSRLNDRVS
1860 1870 1880 1890 1900
NAISSLQSVS DFVLKTIILD SAFDVYTLNL THRDFKLPLC RPPAARYESI
1910 1920 1930 1940 1950
IDLMDIISPG VAFYNYLHRT LIFEYSDYYL PPCEDLRITL SKSKPYHPGA
1960 1970 1980 1990 2000
YVVSKILGKG ERNRPNTWKQ VIQSLSHRNF NAPIINHKLD VKRSAQILYD
2010 2020 2030 2040 2050
SVVKSLRQDR LTEWYEPILP DLFKIGKWLD DRDGSKYRML NRRLDFASLA
2060 2070 2080 2090 2100
DKFKTLNLMV KGETKPKMDL STYDSYNAPA NIVYYQQIVN LYFSPIFLEC
2110 2120 2130 2140 2150
FARLTYCLSD KIVLYSGMNT DVLAELIESK LPLGLNAYHT LEIDFSKFDK
2160 2170 2180 2190 2200
SQGTCFKLYE EMMYKMFGFS PELYDRDFKY TEYFCRAKAT CGVDLELGTQ
2210 2220 2230 2240 2250
RRTGSPNTWL SNTLVTLGMM LSSYDIDDID LLLVSGDDSL IFSRKHLPNK
2260 2270 2280 2290 2300
TQEINKNFGM EAKYIEKSSP YFCSKFIVEL NGKLKVIPDP IRFFEKLSIP
2310 2320 2330 2340 2350
IRQEDFVNGS VVKERFISFK DLMKEYDNDV AVIRIDEAVC YRYSIPVGCS
2360 2370
YAALCYIHCC MSNFVSFRRI YDNCEIVWI
Isoform Replicase 1a (identifier: Q83044-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q83044.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Sequence cautioni
The sequence AAA61798 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U15440 Genomic RNA Translation: AAA61798.1 Sequence problems. |
Keywords - Coding sequence diversityi
Ribosomal frameshiftingCross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U15440 Genomic RNA Translation: AAA61798.1 Sequence problems. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | Q83045 |
Family and domain databases
InterProi | View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR002588, Alphavirus-like_MT_dom IPR043502, DNA/RNA_pol_sf IPR027417, P-loop_NTPase IPR007094, RNA-dir_pol_PSvirus IPR001788, Tymovirus_RNA-dep_RNA_pol |
Pfami | View protein in Pfam PF00978, RdRP_2, 1 hit PF01443, Viral_helicase1, 1 hit PF01660, Vmethyltransf, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51743, ALPHAVIRUS_MT, 1 hit PS51657, PSRV_HELICASE, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | R1AB_LIYV9 | |
Accessioni | Q83045Primary (citable) accession number: Q83045 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 30, 2010 |
Last sequence update: | November 30, 2010 | |
Last modified: | August 12, 2020 | |
This is version 84 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families