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UniProtKB - Q83034 (POLG_RTSVA)

Entry version 112 (07 Apr 2021)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Genome polyprotein

Gene
N/A
Organism
Rice tungro spherical virus (strain A) (RTSV) (Rice tungro spherical waikavirus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Picornain 3C-like protease is a thiol protease that probably cleaves the polyprotein.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2680For picornain 3C-like protease activityPROSITE-ProRule annotation1
Active sitei2717For picornain 3C-like protease activityPROSITE-ProRule annotation1
Active sitei2811For picornain 3C-like protease activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1777 – 1784ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPS protease database

More...MEROPSi		C03.024

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 7 chains:
Putative leader protein
Capsid protein 1
Short name:
CP-1
Alternative name(s):
22.5 kDa protein
Coat protein 1
Capsid protein 2
Short name:
CP-2
Alternative name(s):
26 kDa protein
Coat protein 2
Capsid protein 3
Short name:
CP-3
Alternative name(s):
31 kDa protein
Coat protein 3
Putative helicase (EC:3.6.4.-)
Alternative name(s):
Putative NTP-binding protein
Probable picornain 3C-like protease (EC:3.4.22.-)
Short name:
3C-like protease
Probable RNA-directed RNA polymerase (EC:2.7.7.48)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRice tungro spherical virus (strain A) (RTSV) (Rice tungro spherical waikavirus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri337081 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Picornavirales › Secoviridae › Waikavirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiOryza sativa (Rice) [TaxID: 4530]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007086 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1496 – 1516HelicalSequence analysisAdd BLAST21
Transmembranei1595 – 1615HelicalSequence analysisAdd BLAST21
Transmembranei2363 – 2383HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Capsid protein, Host membrane, Membrane, Virion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2509Q → R: No effect on processing. 1 Publication1
Mutagenesisi2526Q → P: Complete loss of processing between putative helicase and picornain 3C-like protease. 1 Publication1
Mutagenesisi2680H → G: Severe loss of polyprotein processing. 1 Publication1
Mutagenesisi2717E → Q: Complete loss of polyprotein processing. 1 Publication1
Mutagenesisi2735D → E: No effect on polyprotein processing. 1 Publication1
Mutagenesisi2811C → A: Complete loss of polyprotein processing. 1 Publication1
Mutagenesisi2830H → E: Complete loss of polyprotein processing. 1 Publication1
Mutagenesisi2852Q → P: Delayed and partial processing between picornain 3C-like protease and RNA-directed RNA polymerase. 1 Publication1
Mutagenesisi2885Q → L: No effect on processing. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000411401 – 644Putative leader proteinSequence analysisAdd BLAST644
ChainiPRO_0000041141645 – 852Capsid protein 1Add BLAST208
ChainiPRO_0000041142853 – 1055Capsid protein 2Add BLAST203
ChainiPRO_00000411431056 – ?1366Capsid protein 3Add BLAST311
ChainiPRO_0000041144?1367 – 2526Putative helicaseSequence analysisAdd BLAST1160
ChainiPRO_00000411452527 – 2852Probable picornain 3C-like proteaseCuratedAdd BLAST326
ChainiPRO_00000411462853 – 3473Probable RNA-directed RNA polymeraseBy similarityAdd BLAST621

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages by picornain 3C-like protease in vivo yield mature proteins. Picornain 3C-like protease is autocatalytically processed (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei644 – 645Cleavage2
Sitei852 – 853Cleavage2
Sitei1055 – 1056Cleavage2
Sitei2526 – 2527CleavageCurated2
Sitei2852 – 2853CleavageBy similarity2

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q83034

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1751 – 1917SF3 helicasePROSITE-ProRule annotationAdd BLAST167
Domaini2632 – 2850Peptidase C3PROSITE-ProRule annotationAdd BLAST219
Domaini3155 – 3286RdRp catalyticPROSITE-ProRule annotationAdd BLAST132

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili514 – 604Sequence analysisAdd BLAST91

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi630 – 634Poly-Arg5

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Family and domain databases

Conserved Domains Database

More...CDDi		cd00205, rhv_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.10.10, 2 hits
2.60.120.20, 3 hits
3.30.70.270, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR000605, Helicase_SF3_ssDNA/RNA_vir
IPR014759, Helicase_SF3_ssRNA_vir
IPR044067, PCV_3C_PRO
IPR024387, Pept_C3G_Picornavir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001676, Picornavirus_capsid
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR033703, Rhv-like
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR029053, Viral_coat
IPR024379, Waikavirus_capsid-1

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12381, Peptidase_C3G, 1 hit
PF00680, RdRP_1, 1 hit
PF00073, Rhv, 1 hit
PF00910, RNA_helicase, 1 hit
PF12264, Waikav_capsid_1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50494, SSF50494, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51874, PCV_3C_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51218, SF3_HELICASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q83034-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSFLLSSKN QAKLLHAGLE FVGGVRCAHQ GWVSGKAVVF CNYCNFAHRL 
        60         70         80         90        100
YRFYTKNHCV LNKELLKISV EGLLCHCIEQ AFLFRRFYDR RFAWQRKYAK 
       110        120        130        140        150
GFLFDNLSIP FDDCALCPNA GTRLSQTGVS HDHFVCNYVE HLFECASFSR 
       160        170        180        190        200
ETGGKFFRAC SEGWHWNATC TTCGASCRFA NPRENIVIAI FMNFLRVMYD 
       210        220        230        240        250
GNKYYVSLHC DTEWIPVHPL FARLVLMVRG FAPLDNSHVI EEDEMDICGH 
       260        270        280        290        300
SSEVTYEDPS KFAFTHQHVT RGVGMGHLAF CRDANGVDRG EHKFYLHGPF 
       310        320        330        340        350
DLKMTHAMFR VFMILLNCHG YVQSEFRDEF PDIKDRSLCG LLSVAGLRGV 
       360        370        380        390        400
NVSCNEEFIH LHSQFHNGSF RSQRPIPMVY AEPEMYPPLG YVHLTESWVP 
       410        420        430        440        450
RGRLLIDDLP SLMSRVYAES SQAQAGEIYE ETFDEDDLFE LDGEEGTSTR 
       460        470        480        490        500
GLLDLGRRLG GLLLGATKCV KGLHSVIEWP VDVLTKEAED LGTWLADNKK 
       510        520        530        540        550
YVSESTWSCQ VCPEVQDALE KSMREQAKLN AQMISGIKKL ATTMDSATLK 
       560        570        580        590        600
LRDNLKELEQ RISVLEQGAD DTQQVRITNL ENFCEDAAKA FEALRNDIEA 
       610        620        630        640        650
LKKKPAQSVT PLPSPSGNSG TAGEQRPPPR RRRRPPVVEM SEAQAGETVI 
       660        670        680        690        700
VGGDEEQEAH QDSSVAAAGP ADEHNAMLQK IYLGSFKWKV SDGGGSILKT 
       710        720        730        740        750
FSLPSDIWAA NDRMKNFLSY FQYYTCEGMT FTLTITSIGL HGGTLLVAWD 
       760        770        780        790        800
ALSSATRRGI VSMIQLSNLP SMTLHASGSS IGTLTVTSPA IQHQICTSGS 
       810        820        830        840        850
EGSLANLGSL VISVANVLCA DSASAQELNV NAWVQFNKPK LSYWTAQHSI 
       860        870        880        890        900
AQSGGFEESQ DLGDLQAIIA TGKWSTTSDK NLMEIIVHPT ACYVSEKLIY 
       910        920        930        940        950
QTNLSVVAHM FAKWSGSMRY TFVFGASMFD RGKIMVSAVP VQFRNSKLTL 
       960        970        980        990       1000
SQMAAFPSMV CDLSMETREF TFEVPYISIG KMSLVCKDYL FDISSYNADL 
      1010       1020       1030       1040       1050
VVSRLHVMIL DPLVKTGNAS NSIGFYVVAG PGKGFKLHQM CGVKSQFAHD 
      1060       1070       1080       1090       1100
VLTAQDFGRS LSCSRLLGNG FKEWCSRESL LMRVPLKSGK KRAFKYAVTP 
      1110       1120       1130       1140       1150
RMRTLPPEAT SLSWLSQIFV EWRGSLTYTI HVQSGSAIQH SYMRIWYDPN 
      1160       1170       1180       1190       1200
GKTDEKEVKF LDSAHPPAGI KVYHWDLKIG DSFRFTVPYC ARTEKLQIPK 
      1210       1220       1230       1240       1250
AYASTPYEWL TMYNGAVTFD LRSGADMELF VSIAGGDDFE MFEQTVPPKC 
      1260       1270       1280       1290       1300
GSVSDSYTVL SYADDVKSVT EVPNKTTYLA DEQPTTSAPR TSIVNTEDDP 
      1310       1320       1330       1340       1350
PTEGEIARTT NGTLVQYRGG AWKPMVERTP TMSKKQVGPE LTVSDPQMYK 
      1360       1370       1380       1390       1400
CIKNMNKNVK ILTDRQCTAK LANIVDSAQE LVGSNSTFVE DLAVGAKQIR 
      1410       1420       1430       1440       1450
KFGESLDVFE GSMSAAKTAE LIDNTHAAFS GPADGSPISN VVQLLLPMLS 
      1460       1470       1480       1490       1500
SIKGMSGKME SKMASLTAMF QPCKKAITHL IERSFPYLAC KGFKTDKWIW 
      1510       1520       1530       1540       1550
AALASILVGA ALLHYYRSDL KFVKKWSVMC MIIWAPLLAE KAYHLGTWIK 
      1560       1570       1580       1590       1600
EKFLKSLPRT RTIKDSCRKH SLAGAFECLA SASCAYIKDN WAKTMSSLLT 
      1610       1620       1630       1640       1650
ILSVVASLVM WGKIPDDKEI TSFADKFHSI GKKGRSITNI IGGFEKITSV 
      1660       1670       1680       1690       1700
CKKWSETLVS WIVSNVSGGI PKEDLAMTAY LGFKIHDWVR ETRDMALMEN 
      1710       1720       1730       1740       1750
RFRGFGGDEH LVKVRRLYGH SLKIDNALME KQIVPDMQLS LIIKECRQKC 
      1760       1770       1780       1790       1800
LELMNESYTY KGMKQSRIDP LHVCMLGAPG VGKSTIAHVV INHLLDHRGE 
      1810       1820       1830       1840       1850
PEVDRIYTRS CADAYWSNYH QEPVILYDDL GAIKSNLRLS DYAEIMGIKT 
      1860       1870       1880       1890       1900
NDPFSVPMAA VEDKGKHCTS KYVFSCTNVL NLDDTGDVVT KMAYYRRRNV 
      1910       1920       1930       1940       1950
LVKVERDPDV PKNEANPTEG LVFTVLGHDQ NCQGDPQFVV KENWDEPFLR 
      1960       1970       1980       1990       2000
EVDTEGWRFE RVEYRTFLRF LCMYTDAYMY SQEQVLQGIK TFKMNPFAPE 
      2010       2020       2030       2040       2050
PEFAQAQNGE AAECEIVEEM QEVPGEAPQE AKELVKIETA PNMDELVEAF 
      2060       2070       2080       2090       2100
NKLRVTPGHL NDILRDGSGC YIDEWAIAGP RWLSFHELLP FTCGCHHTRV 
      2110       2120       2130       2140       2150
CDFNIVYNNM CKAVRSQSVH FKYRANQAIK YAYTHKLHSQ CRYSIDFEKL 
      2160       2170       2180       2190       2200
RECNPLDVFV CVLSKYTADD HSFERRCPKK MNVVRMQRPP VFELKMRPPS 
      2210       2220       2230       2240       2250
DSVVVEDEQG QRIFEWPHLY IFLRYRAIEF KDDKGSLTVR EDAGADVCPW 
      2260       2270       2280       2290       2300
NEFLKLPWLD GDQLKSVLPA HLHRMVQARL EQVEIMEENG NYSGEMRNAI 
      2310       2320       2330       2340       2350
AEIKEYLDQD HQWVAALVLV ACAVKERRRM THDKLHRKSF NALDKLDAWY 
      2360       2370       2380       2390       2400
TTTAPKTSKK MKILLAIGAS VAVAGVAVGA VILLQKTNLF GSKEDEEIEG 
      2410       2420       2430       2440       2450
EEGETQASGA HESDGIVTQH LKRDIRPKMR VTYTDHHVAE AHEEKDAEKP 
      2460       2470       2480       2490       2500
RKSGNPTRKS YLGLSPGFAE RGMGVTYEEH TPLKDALLDE SNKVFRRKIV 
      2510       2520       2530       2540       2550
ASVESAVKQG GKASKDTVLS QIGDWQDKVK ATGVIAARQL EASGSLKKIH 
      2560       2570       2580       2590       2600
NLNSRRTSSH VMPGLVVHDG AFERSDEVDA ELHRITIDEV KSCPKMIKEG 
      2610       2620       2630       2640       2650
VSTLSVKKAS VGMLALQKAE SQLSFPFTSR AGVDRDLSMT NLIDTHMAGM 
      2660       2670       2680       2690       2700
SCIIISELGN VFRTFGVLRL CGTYVCMPAH YLDEITSEHT LYFVCPSKIT 
      2710       2720       2730       2740       2750
QIQLERHRVC LVNGFQETVV WDLGPSVPPS RNYIDFIANA DDWKNYKATS 
      2760       2770       2780       2790       2800
GALVMSKYSV DSMLQCVHFL DSIELTEANV SVPTSYYEAN GGIHTIISGL 
      2810       2820       2830       2840       2850
RYRVHCMPGF CGRAIMRADA TCFRKIIGMH VSGLRNKCMG YAETLTQEHL 
      2860       2870       2880       2890       2900
MQAIETLKET GLLKHIPKGA IGAGEEKLPE HSKKQSLSLE GKGNLGIVGQ 
      2910       2920       2930       2940       2950
LTAQLVPTSV TKTTICKSMI HGLIGEIKTE PSVLSAWDRR LPFPPGEWDP 
      2960       2970       2980       2990       3000
MKDAVKKYGS YILPFPTEEI QEVENFLIKK FRRKENSRRT RNVNSLEVGI 
      3010       3020       3030       3040       3050
NGIDGSDFWS PIEMKTSPGY PYILKRPSGA QGKKYLFEEL EPYPSGRPKY 
      3060       3070       3080       3090       3100
AMKDPELIEN YERIKEEVTS GVKPSIMTME CLKDERRKLA KIYEKPATRT 
      3110       3120       3130       3140       3150
FTILSPEVNI LFRQYFGDFA AMVMSTRREH FSQVGINPES MEWSDLINSL 
      3160       3170       3180       3190       3200
LRVNTKGFAG DYSKFDGIGS PAIYHSIVNV VNAWYNDGEV NARARHSLIS 
      3210       3220       3230       3240       3250
SIVHRDGICG DLILRYSQGM PSGFAMTVIF NSFVNYYFMA LAWMSTVGSS 
      3260       3270       3280       3290       3300
LLSPQGSCKD FDTYCKIVAY GDDNVVSVHE EFLDVYNLQT VAAYLSHFGV 
      3310       3320       3330       3340       3350
TYTDGDKNPI HMSKPYEDIT KMSFLKRGFE RVESSGFLWK APLDKTSIEE 
      3360       3370       3380       3390       3400
RLNWIRDCPT PVEALEQNIE SALHEAAIHG RDYFDDLVRR LNSALTRVML 
      3410       3420       3430       3440       3450
PPTDISFEEC QARWWASVTG ALRAADYTSL VRRASSGHVE FNKKYRDMFR 
      3460       3470 
QQDLPLKEIL MKSKPVALLD LEV
Length:3,473
Mass (Da):390,264
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF560A352130E7E96
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M95497 Genomic RNA Translation: AAA66056.1

Protein sequence database of the Protein Information Resource

More...PIRi		A46112
S27927

NCBI Reference Sequences

More...RefSeqi		NP_042507.1, NC_001632.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1497257

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		vg:1497257

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95497 Genomic RNA Translation: AAA66056.1
PIRiA46112
S27927
RefSeqiNP_042507.1, NC_001632.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein family/group databases

MEROPSiC03.024

Proteomic databases

PRIDEiQ83034

Genome annotation databases

GeneIDi1497257
KEGGivg:1497257

Family and domain databases

CDDicd00205, rhv_like, 1 hit
Gene3Di2.40.10.10, 2 hits
2.60.120.20, 3 hits
3.30.70.270, 1 hit
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR000605, Helicase_SF3_ssDNA/RNA_vir
IPR014759, Helicase_SF3_ssRNA_vir
IPR044067, PCV_3C_PRO
IPR024387, Pept_C3G_Picornavir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001676, Picornavirus_capsid
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR033703, Rhv-like
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR029053, Viral_coat
IPR024379, Waikavirus_capsid-1
PfamiView protein in Pfam
PF12381, Peptidase_C3G, 1 hit
PF00680, RdRP_1, 1 hit
PF00073, Rhv, 1 hit
PF00910, RNA_helicase, 1 hit
PF12264, Waikav_capsid_1, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51874, PCV_3C_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51218, SF3_HELICASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLG_RTSVA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q83034
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: November 1, 1996
Last modified: April 7, 2021
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome
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