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Entry version 112 (07 Apr 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Genome polyprotein

Gene
N/A
Organism
Rice tungro spherical virus (strain A) (RTSV) (Rice tungro spherical waikavirus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Picornain 3C-like protease is a thiol protease that probably cleaves the polyprotein.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2680For picornain 3C-like protease activityPROSITE-ProRule annotation1
Active sitei2717For picornain 3C-like protease activityPROSITE-ProRule annotation1
Active sitei2811For picornain 3C-like protease activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1777 – 1784ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C03.024

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 7 chains:
Capsid protein 1
Short name:
CP-1
Alternative name(s):
22.5 kDa protein
Coat protein 1
Capsid protein 2
Short name:
CP-2
Alternative name(s):
26 kDa protein
Coat protein 2
Capsid protein 3
Short name:
CP-3
Alternative name(s):
31 kDa protein
Coat protein 3
Putative helicase (EC:3.6.4.-)
Alternative name(s):
Putative NTP-binding protein
Probable picornain 3C-like protease (EC:3.4.22.-)
Short name:
3C-like protease
Probable RNA-directed RNA polymerase (EC:2.7.7.48)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRice tungro spherical virus (strain A) (RTSV) (Rice tungro spherical waikavirus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri337081 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesPicornaviralesSecoviridaeWaikavirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiOryza sativa (Rice) [TaxID: 4530]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007086 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1496 – 1516HelicalSequence analysisAdd BLAST21
Transmembranei1595 – 1615HelicalSequence analysisAdd BLAST21
Transmembranei2363 – 2383HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Capsid protein, Host membrane, Membrane, Virion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2509Q → R: No effect on processing. 1 Publication1
Mutagenesisi2526Q → P: Complete loss of processing between putative helicase and picornain 3C-like protease. 1 Publication1
Mutagenesisi2680H → G: Severe loss of polyprotein processing. 1 Publication1
Mutagenesisi2717E → Q: Complete loss of polyprotein processing. 1 Publication1
Mutagenesisi2735D → E: No effect on polyprotein processing. 1 Publication1
Mutagenesisi2811C → A: Complete loss of polyprotein processing. 1 Publication1
Mutagenesisi2830H → E: Complete loss of polyprotein processing. 1 Publication1
Mutagenesisi2852Q → P: Delayed and partial processing between picornain 3C-like protease and RNA-directed RNA polymerase. 1 Publication1
Mutagenesisi2885Q → L: No effect on processing. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000411401 – 644Putative leader proteinSequence analysisAdd BLAST644
ChainiPRO_0000041141645 – 852Capsid protein 1Add BLAST208
ChainiPRO_0000041142853 – 1055Capsid protein 2Add BLAST203
ChainiPRO_00000411431056 – ?1366Capsid protein 3Add BLAST311
ChainiPRO_0000041144?1367 – 2526Putative helicaseSequence analysisAdd BLAST1160
ChainiPRO_00000411452527 – 2852Probable picornain 3C-like proteaseCuratedAdd BLAST326
ChainiPRO_00000411462853 – 3473Probable RNA-directed RNA polymeraseBy similarityAdd BLAST621

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages by picornain 3C-like protease in vivo yield mature proteins. Picornain 3C-like protease is autocatalytically processed (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei644 – 645Cleavage2
Sitei852 – 853Cleavage2
Sitei1055 – 1056Cleavage2
Sitei2526 – 2527CleavageCurated2
Sitei2852 – 2853CleavageBy similarity2

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q83034

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1751 – 1917SF3 helicasePROSITE-ProRule annotationAdd BLAST167
Domaini2632 – 2850Peptidase C3PROSITE-ProRule annotationAdd BLAST219
Domaini3155 – 3286RdRp catalyticPROSITE-ProRule annotationAdd BLAST132

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili514 – 604Sequence analysisAdd BLAST91

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi630 – 634Poly-Arg5

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00205, rhv_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.10, 2 hits
2.60.120.20, 3 hits
3.30.70.270, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR000605, Helicase_SF3_ssDNA/RNA_vir
IPR014759, Helicase_SF3_ssRNA_vir
IPR044067, PCV_3C_PRO
IPR024387, Pept_C3G_Picornavir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001676, Picornavirus_capsid
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR033703, Rhv-like
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR029053, Viral_coat
IPR024379, Waikavirus_capsid-1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12381, Peptidase_C3G, 1 hit
PF00680, RdRP_1, 1 hit
PF00073, Rhv, 1 hit
PF00910, RNA_helicase, 1 hit
PF12264, Waikav_capsid_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51874, PCV_3C_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51218, SF3_HELICASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q83034-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSFLLSSKN QAKLLHAGLE FVGGVRCAHQ GWVSGKAVVF CNYCNFAHRL
60 70 80 90 100
YRFYTKNHCV LNKELLKISV EGLLCHCIEQ AFLFRRFYDR RFAWQRKYAK
110 120 130 140 150
GFLFDNLSIP FDDCALCPNA GTRLSQTGVS HDHFVCNYVE HLFECASFSR
160 170 180 190 200
ETGGKFFRAC SEGWHWNATC TTCGASCRFA NPRENIVIAI FMNFLRVMYD
210 220 230 240 250
GNKYYVSLHC DTEWIPVHPL FARLVLMVRG FAPLDNSHVI EEDEMDICGH
260 270 280 290 300
SSEVTYEDPS KFAFTHQHVT RGVGMGHLAF CRDANGVDRG EHKFYLHGPF
310 320 330 340 350
DLKMTHAMFR VFMILLNCHG YVQSEFRDEF PDIKDRSLCG LLSVAGLRGV
360 370 380 390 400
NVSCNEEFIH LHSQFHNGSF RSQRPIPMVY AEPEMYPPLG YVHLTESWVP
410 420 430 440 450
RGRLLIDDLP SLMSRVYAES SQAQAGEIYE ETFDEDDLFE LDGEEGTSTR
460 470 480 490 500
GLLDLGRRLG GLLLGATKCV KGLHSVIEWP VDVLTKEAED LGTWLADNKK
510 520 530 540 550
YVSESTWSCQ VCPEVQDALE KSMREQAKLN AQMISGIKKL ATTMDSATLK
560 570 580 590 600
LRDNLKELEQ RISVLEQGAD DTQQVRITNL ENFCEDAAKA FEALRNDIEA
610 620 630 640 650
LKKKPAQSVT PLPSPSGNSG TAGEQRPPPR RRRRPPVVEM SEAQAGETVI
660 670 680 690 700
VGGDEEQEAH QDSSVAAAGP ADEHNAMLQK IYLGSFKWKV SDGGGSILKT
710 720 730 740 750
FSLPSDIWAA NDRMKNFLSY FQYYTCEGMT FTLTITSIGL HGGTLLVAWD
760 770 780 790 800
ALSSATRRGI VSMIQLSNLP SMTLHASGSS IGTLTVTSPA IQHQICTSGS
810 820 830 840 850
EGSLANLGSL VISVANVLCA DSASAQELNV NAWVQFNKPK LSYWTAQHSI
860 870 880 890 900
AQSGGFEESQ DLGDLQAIIA TGKWSTTSDK NLMEIIVHPT ACYVSEKLIY
910 920 930 940 950
QTNLSVVAHM FAKWSGSMRY TFVFGASMFD RGKIMVSAVP VQFRNSKLTL
960 970 980 990 1000
SQMAAFPSMV CDLSMETREF TFEVPYISIG KMSLVCKDYL FDISSYNADL
1010 1020 1030 1040 1050
VVSRLHVMIL DPLVKTGNAS NSIGFYVVAG PGKGFKLHQM CGVKSQFAHD
1060 1070 1080 1090 1100
VLTAQDFGRS LSCSRLLGNG FKEWCSRESL LMRVPLKSGK KRAFKYAVTP
1110 1120 1130 1140 1150
RMRTLPPEAT SLSWLSQIFV EWRGSLTYTI HVQSGSAIQH SYMRIWYDPN
1160 1170 1180 1190 1200
GKTDEKEVKF LDSAHPPAGI KVYHWDLKIG DSFRFTVPYC ARTEKLQIPK
1210 1220 1230 1240 1250
AYASTPYEWL TMYNGAVTFD LRSGADMELF VSIAGGDDFE MFEQTVPPKC
1260 1270 1280 1290 1300
GSVSDSYTVL SYADDVKSVT EVPNKTTYLA DEQPTTSAPR TSIVNTEDDP
1310 1320 1330 1340 1350
PTEGEIARTT NGTLVQYRGG AWKPMVERTP TMSKKQVGPE LTVSDPQMYK
1360 1370 1380 1390 1400
CIKNMNKNVK ILTDRQCTAK LANIVDSAQE LVGSNSTFVE DLAVGAKQIR
1410 1420 1430 1440 1450
KFGESLDVFE GSMSAAKTAE LIDNTHAAFS GPADGSPISN VVQLLLPMLS
1460 1470 1480 1490 1500
SIKGMSGKME SKMASLTAMF QPCKKAITHL IERSFPYLAC KGFKTDKWIW
1510 1520 1530 1540 1550
AALASILVGA ALLHYYRSDL KFVKKWSVMC MIIWAPLLAE KAYHLGTWIK
1560 1570 1580 1590 1600
EKFLKSLPRT RTIKDSCRKH SLAGAFECLA SASCAYIKDN WAKTMSSLLT
1610 1620 1630 1640 1650
ILSVVASLVM WGKIPDDKEI TSFADKFHSI GKKGRSITNI IGGFEKITSV
1660 1670 1680 1690 1700
CKKWSETLVS WIVSNVSGGI PKEDLAMTAY LGFKIHDWVR ETRDMALMEN
1710 1720 1730 1740 1750
RFRGFGGDEH LVKVRRLYGH SLKIDNALME KQIVPDMQLS LIIKECRQKC
1760 1770 1780 1790 1800
LELMNESYTY KGMKQSRIDP LHVCMLGAPG VGKSTIAHVV INHLLDHRGE
1810 1820 1830 1840 1850
PEVDRIYTRS CADAYWSNYH QEPVILYDDL GAIKSNLRLS DYAEIMGIKT
1860 1870 1880 1890 1900
NDPFSVPMAA VEDKGKHCTS KYVFSCTNVL NLDDTGDVVT KMAYYRRRNV
1910 1920 1930 1940 1950
LVKVERDPDV PKNEANPTEG LVFTVLGHDQ NCQGDPQFVV KENWDEPFLR
1960 1970 1980 1990 2000
EVDTEGWRFE RVEYRTFLRF LCMYTDAYMY SQEQVLQGIK TFKMNPFAPE
2010 2020 2030 2040 2050
PEFAQAQNGE AAECEIVEEM QEVPGEAPQE AKELVKIETA PNMDELVEAF
2060 2070 2080 2090 2100
NKLRVTPGHL NDILRDGSGC YIDEWAIAGP RWLSFHELLP FTCGCHHTRV
2110 2120 2130 2140 2150
CDFNIVYNNM CKAVRSQSVH FKYRANQAIK YAYTHKLHSQ CRYSIDFEKL
2160 2170 2180 2190 2200
RECNPLDVFV CVLSKYTADD HSFERRCPKK MNVVRMQRPP VFELKMRPPS
2210 2220 2230 2240 2250
DSVVVEDEQG QRIFEWPHLY IFLRYRAIEF KDDKGSLTVR EDAGADVCPW
2260 2270 2280 2290 2300
NEFLKLPWLD GDQLKSVLPA HLHRMVQARL EQVEIMEENG NYSGEMRNAI
2310 2320 2330 2340 2350
AEIKEYLDQD HQWVAALVLV ACAVKERRRM THDKLHRKSF NALDKLDAWY
2360 2370 2380 2390 2400
TTTAPKTSKK MKILLAIGAS VAVAGVAVGA VILLQKTNLF GSKEDEEIEG
2410 2420 2430 2440 2450
EEGETQASGA HESDGIVTQH LKRDIRPKMR VTYTDHHVAE AHEEKDAEKP
2460 2470 2480 2490 2500
RKSGNPTRKS YLGLSPGFAE RGMGVTYEEH TPLKDALLDE SNKVFRRKIV
2510 2520 2530 2540 2550
ASVESAVKQG GKASKDTVLS QIGDWQDKVK ATGVIAARQL EASGSLKKIH
2560 2570 2580 2590 2600
NLNSRRTSSH VMPGLVVHDG AFERSDEVDA ELHRITIDEV KSCPKMIKEG
2610 2620 2630 2640 2650
VSTLSVKKAS VGMLALQKAE SQLSFPFTSR AGVDRDLSMT NLIDTHMAGM
2660 2670 2680 2690 2700
SCIIISELGN VFRTFGVLRL CGTYVCMPAH YLDEITSEHT LYFVCPSKIT
2710 2720 2730 2740 2750
QIQLERHRVC LVNGFQETVV WDLGPSVPPS RNYIDFIANA DDWKNYKATS
2760 2770 2780 2790 2800
GALVMSKYSV DSMLQCVHFL DSIELTEANV SVPTSYYEAN GGIHTIISGL
2810 2820 2830 2840 2850
RYRVHCMPGF CGRAIMRADA TCFRKIIGMH VSGLRNKCMG YAETLTQEHL
2860 2870 2880 2890 2900
MQAIETLKET GLLKHIPKGA IGAGEEKLPE HSKKQSLSLE GKGNLGIVGQ
2910 2920 2930 2940 2950
LTAQLVPTSV TKTTICKSMI HGLIGEIKTE PSVLSAWDRR LPFPPGEWDP
2960 2970 2980 2990 3000
MKDAVKKYGS YILPFPTEEI QEVENFLIKK FRRKENSRRT RNVNSLEVGI
3010 3020 3030 3040 3050
NGIDGSDFWS PIEMKTSPGY PYILKRPSGA QGKKYLFEEL EPYPSGRPKY
3060 3070 3080 3090 3100
AMKDPELIEN YERIKEEVTS GVKPSIMTME CLKDERRKLA KIYEKPATRT
3110 3120 3130 3140 3150
FTILSPEVNI LFRQYFGDFA AMVMSTRREH FSQVGINPES MEWSDLINSL
3160 3170 3180 3190 3200
LRVNTKGFAG DYSKFDGIGS PAIYHSIVNV VNAWYNDGEV NARARHSLIS
3210 3220 3230 3240 3250
SIVHRDGICG DLILRYSQGM PSGFAMTVIF NSFVNYYFMA LAWMSTVGSS
3260 3270 3280 3290 3300
LLSPQGSCKD FDTYCKIVAY GDDNVVSVHE EFLDVYNLQT VAAYLSHFGV
3310 3320 3330 3340 3350
TYTDGDKNPI HMSKPYEDIT KMSFLKRGFE RVESSGFLWK APLDKTSIEE
3360 3370 3380 3390 3400
RLNWIRDCPT PVEALEQNIE SALHEAAIHG RDYFDDLVRR LNSALTRVML
3410 3420 3430 3440 3450
PPTDISFEEC QARWWASVTG ALRAADYTSL VRRASSGHVE FNKKYRDMFR
3460 3470
QQDLPLKEIL MKSKPVALLD LEV
Length:3,473
Mass (Da):390,264
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF560A352130E7E96
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M95497 Genomic RNA Translation: AAA66056.1

Protein sequence database of the Protein Information Resource

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PIRi
A46112
S27927

NCBI Reference Sequences

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RefSeqi
NP_042507.1, NC_001632.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
1497257

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
vg:1497257

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95497 Genomic RNA Translation: AAA66056.1
PIRiA46112
S27927
RefSeqiNP_042507.1, NC_001632.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiC03.024

Proteomic databases

PRIDEiQ83034

Genome annotation databases

GeneIDi1497257
KEGGivg:1497257

Family and domain databases

CDDicd00205, rhv_like, 1 hit
Gene3Di2.40.10.10, 2 hits
2.60.120.20, 3 hits
3.30.70.270, 1 hit
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR000605, Helicase_SF3_ssDNA/RNA_vir
IPR014759, Helicase_SF3_ssRNA_vir
IPR044067, PCV_3C_PRO
IPR024387, Pept_C3G_Picornavir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001676, Picornavirus_capsid
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR033703, Rhv-like
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR029053, Viral_coat
IPR024379, Waikavirus_capsid-1
PfamiView protein in Pfam
PF12381, Peptidase_C3G, 1 hit
PF00680, RdRP_1, 1 hit
PF00073, Rhv, 1 hit
PF00910, RNA_helicase, 1 hit
PF12264, Waikav_capsid_1, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51874, PCV_3C_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51218, SF3_HELICASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLG_RTSVA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q83034
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: November 1, 1996
Last modified: April 7, 2021
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome
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