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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1

Gene

gpmA1

Organism
Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2 (gpmA2), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1 (gpmA1)
  4. Enolase (eno)
  5. Pyruvate kinase (pykA1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei15Tele-phosphohistidine intermediateUniRule annotation1
Binding sitei66SubstrateUniRule annotation1
Active sitei93Proton donor/acceptorUniRule annotation1
Sitei188Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1UniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAM 1UniRule annotation
Short name:
PGAM 1UniRule annotation
Short name:
Phosphoglyceromutase 1UniRule annotation
Short name:
dPGM 1UniRule annotation
Gene namesi
Name:gpmA1UniRule annotation
Ordered Locus Names:NE0178
OrganismiNitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)
Taxonomic identifieri228410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
Proteomesi
  • UP000001416 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001798971 – 2342,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1Add BLAST234

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi228410.NE0178

Structurei

3D structure databases

ProteinModelPortaliQ82XS4
SMRiQ82XS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni14 – 21Substrate bindingUniRule annotation8
Regioni27 – 28Substrate bindingUniRule annotation2
Regioni93 – 96Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0588 LUCA
HOGENOMiHOG000221682
KOiK01834
OMAiPEIRQGK
OrthoDBiPOG091H02BM
PhylomeDBiQ82XS4

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
HAMAPiMF_01039 PGAM_GpmA, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR001345 PG/BPGM_mutase_AS
IPR005952 Phosphogly_mut1
PANTHERiPTHR11931 PTHR11931, 1 hit
PfamiView protein in Pfam
PF00300 His_Phos_1, 2 hits
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
TIGRFAMsiTIGR01258 pgm_1, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q82XS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEIQEPIRL VLLRHGQSIW NQDRHFTGWG DIVLSPQGEQ EALRAGHLLK
60 70 80 90 100
QAGFTFDACF CSELQRASDT LAIVQSVMGL NHLSTYRTWR LNERHYGALE
110 120 130 140 150
GMRPWAAIRK FGIWSTMKSQ IRFDAAPPLL MPDDPRAPVN QPRYAAVDRT
160 170 180 190 200
QLPLAESMQQ TLERVRPLWQ ETILPEIRQG KRLLIVSHQN LLKTLVMQLE
210 220 230
GLTGAQIMRL SITTGHPLCY ELDHSLVPVK RYYL
Length:234
Mass (Da):26,889
Last modified:June 1, 2003 - v1
Checksum:i40D612055414EF38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA Translation: CAD84089.1

Genome annotation databases

EnsemblBacteriaiCAD84089; CAD84089; NE0178
KEGGineu:NE0178

Similar proteinsi

Entry informationi

Entry nameiGPMA1_NITEU
AccessioniPrimary (citable) accession number: Q82XS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2003
Last modified: June 7, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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