UniProtKB - Q82JN1 (Q82JN1_STRAW)
Protein
L-glutamate gamma-semialdehyde dehydrogenase
Gene
rocA
Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Functioni
Catalytic activityi
- EC:1.2.1.88ARBA annotation
: L-proline degradation into L-glutamate Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes L-glutamate from L-proline.ARBA annotationProteins known to be involved in the 2 steps of the subpathway in this organism are:
- Proline dehydrogenase (putA)
- L-glutamate gamma-semialdehyde dehydrogenase (rocA)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from L-proline, the pathway L-proline degradation into L-glutamate and in Amino-acid degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 328 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 1-pyrroline-5-carboxylate dehydrogenase activity Source: UniProtKB-EC
- oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Source: InterPro
GO - Biological processi
- proline catabolic process to glutamate Source: UniProtKB-UniPathway
Keywordsi
Molecular function | OxidoreductaseARBA annotation |
Biological process | Proline metabolismARBA annotation |
Enzyme and pathway databases
BioCyci | SAVE227882:G1G23-2880-MONOMER |
UniPathwayi | UPA00261;UER00374 |
Names & Taxonomyi
Protein namesi | Recommended name: L-glutamate gamma-semialdehyde dehydrogenaseARBA annotation (EC:1.2.1.88ARBA annotation) |
Gene namesi | Name:rocAImported ORF Names:SAVERM_2723Imported |
Organismi | Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)Imported |
Taxonomic identifieri | 227882 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces › |
Proteomesi |
|
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 56 – 526 | AldedhInterPro annotationAdd BLAST | 471 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 22 | DisorderedSequence analysisAdd BLAST | 22 |
Phylogenomic databases
eggNOGi | COG1012, Bacteria |
HOGENOMi | CLU_005391_4_1_11 |
OMAi | CTDPENE |
OrthoDBi | 744602at2 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR005931, P5CDH/ALDH4A1 |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
TIGRFAMsi | TIGR01236, D1pyr5carbox1, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q82JN1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDAVTQVPTP VNEPVHGYAP GSPERARLEA KLKELAENPI ELPMTIGGEK
60 70 80 90 100
RLGGGERFEV VQPHNHKAVI GTGAHATQQD AQDAIDAALA AAPAWRAMSF
110 120 130 140 150
DDRAAIILRA AELLSGPWRE TLAASTMLGQ SKTAQQAEID CPCELVDFWR
160 170 180 190 200
FNVKYARDLL AEQPPANSPG VWNRLDHRPL EGFVYAITPF NFSAIAGNLP
210 220 230 240 250
TAPALMGNVV VWKPSPTQTH AAVLLMRLLE EAGLPKGVIN LVTGDGIEVS
260 270 280 290 300
KVALEHRDLA GIHFTGSTKT FQYLWKTVGN NIEKYRSYPR LVGETGGKDF
310 320 330 340 350
LVAHPSADRA VLKTALTRGA FEYQGQKCSA TSRAYLPASI WNSGFKEEFA
360 370 380 390 400
AEVDYLTMGD VTDLSNFVGA VIDERSFAKN KAAIDRAKSD PTCTIVAGGE
410 420 430 440 450
YDDSVGYFVR PTVVECSDPE NEVFKTEYFG PFLAVHVYED DAYDEMLTQM
460 470 480 490 500
ESASDYALTG AVVSNDRAAA AYTMDKLRYA AGNFYINDKS TGAVVGQQPF
510 520 530 540
GGGRASGTND KAGAPQNLMR WTLTRAIKET LVPPTDYTYP HMG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000030 Genomic DNA Translation: BAC70434.1 |
RefSeqi | WP_010984155.1, NZ_JZJK01000071.1 |
Genome annotation databases
EnsemblBacteriai | BAC70434; BAC70434; SAVERM_2723 |
KEGGi | sma:SAVERM_2723 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000030 Genomic DNA Translation: BAC70434.1 |
RefSeqi | WP_010984155.1, NZ_JZJK01000071.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 227882.SAV_2723 |
Genome annotation databases
EnsemblBacteriai | BAC70434; BAC70434; SAVERM_2723 |
KEGGi | sma:SAVERM_2723 |
Phylogenomic databases
eggNOGi | COG1012, Bacteria |
HOGENOMi | CLU_005391_4_1_11 |
OMAi | CTDPENE |
OrthoDBi | 744602at2 |
Enzyme and pathway databases
UniPathwayi | UPA00261;UER00374 |
BioCyci | SAVE227882:G1G23-2880-MONOMER |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR005931, P5CDH/ALDH4A1 |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
TIGRFAMsi | TIGR01236, D1pyr5carbox1, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q82JN1_STRAW | |
Accessioni | Q82JN1Primary (citable) accession number: Q82JN1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2003 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |