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Entry version 97 (13 Nov 2019)
Sequence version 1 (01 Jun 2003)
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Protein

FO synthase

Gene

fbiC

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 2 [4Fe-4S] clusters. The clusters are coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: coenzyme F0 biosynthesis

This protein is involved in the pathway coenzyme F0 biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway coenzyme F0 biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi83Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi87Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi90Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi542Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi546Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi549Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase, Transferase
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SAVE227882:G1G23-3986-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00072

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FO synthase
Including the following 2 domains:
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase (EC:4.3.1.32)
5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase (EC:2.5.1.147)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fbiC
Ordered Locus Names:SAV_3794
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri227882 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000428 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001477741 – 861FO synthaseAdd BLAST861

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
227882.SAV_3794

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni70 – 401CofG-likeAdd BLAST332
Regioni505 – 838CofH-likeAdd BLAST334

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the radical SAM superfamily. CofG family.Curated
In the C-terminal section; belongs to the radical SAM superfamily. CofH family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105DKF Bacteria
COG1060 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000020613

KEGG Orthology (KO)

More...
KOi
K11779

Identification of Orthologs from Complete Genome Data

More...
OMAi
HWVGHLN

Database of Orthologous Groups

More...
OrthoDBi
419725at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_01611 FO_synth_sub1, 1 hit
MF_01612 FO_synth_sub2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785 Aldolase_TIM
IPR019939 CofG_family
IPR019940 CofH_family
IPR006638 Elp3/MiaB/NifB
IPR034405 F420
IPR020050 FO_synthase_su2
IPR007197 rSAM

The PANTHER Classification System

More...
PANTHERi
PTHR43076 PTHR43076, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04055 Radical_SAM, 2 hits

Structure-Function Linkage Database

More...
SFLDi
SFLDF00293 ((2_3_4_5-tetrahydroxypentyl)a, 1 hit
SFLDF00294 7_8-didemethyl-8-hydroxy-5-dea, 1 hit
SFLDF00343 aminofutalosine_synthase_(mqnE, 1 hit
SFLDS00029 Radical_SAM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00729 Elp3, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03550 F420_cofG, 1 hit
TIGR03551 F420_cofH, 1 hit
TIGR00423 TIGR00423, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q82GV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTSATSGTG PTANSMRRAL KRARDGVALD VTEAAVLLQA RGEDLDDLTA
60 70 80 90 100
SAARVRDAGL EAAGRAGVIT YSKSVFIPLT RLCRDKCHYC TFVTVPGKLR
110 120 130 140 150
RAGHGMFMSP DEVLDIARKG AALGCKEALI TLGDKPEDRW PEAREWLDAH
160 170 180 190 200
GYDDTIAYVR AISIRILEET GLLPHLNPGV MSWTDFQRLK PVAPSMGMML
210 220 230 240 250
ETTATRLWSE PGGPHHGSPD KEPAVRLRVL EDAGRSSVPF TSGILIGIGE
260 270 280 290 300
TYEERAESLF ALRKISRAYH GIQELIIQNF RAKPDTAMRG MPDAELDELI
310 320 330 340 350
ATVAVARHIM GPRACLQAPP NLVDSEYGRL IGAGIDDWGG VSPLTIDHVN
360 370 380 390 400
PERPWPQIDL LREQSAQAGF ELRERLCVYP EFVQRGEPWL DPRLLPHVRA
410 420 430 440 450
LADPASGLAH ADATVEGHPW QEPEEAFVAQ GRTDLHHSID TEGRTGDRRD
460 470 480 490 500
DFDVVYGDWE ALREAAAPGM VPERIDTDVR QALATAANDP TRLTDAEALA
510 520 530 540 550
LLHADGPALD ALTRIADDVR KAAVGDDVTY IVTRNINFTN VCYTGCRFCA
560 570 580 590 600
FAQRRTDADA YTLSLEQVAD RAQQAWDVGA VEVCMQGGIH PDLPGTAYFD
610 620 630 640 650
IAKAVKERVP GMHVHAFSPM EVVNGATRTG LSIREWLTAA KEAGLDSIPG
660 670 680 690 700
TAAEILDDEV RWVLTKGKLP TATWIEVITT AHELGIRSSS TMMYGHVDQP
710 720 730 740 750
RHWLGHFRTL ARIQQQTGGF TEFVTLPFIH TNAPVYLAGI ARPGPTTRDN
760 770 780 790 800
RAVMAMARLL LHPHIPNIQT SWVKLGTEGA AEMLRSGAND LGGTLMEETI
810 820 830 840 850
SRMAGSSYGS YKSVKDLIAV AEAAGRPAKP RTTLYGEVPQ ERQRAAAASD
860
GHLPELLPVL D
Length:861
Mass (Da):93,933
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7923745FD5610F0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BA000030 Genomic DNA Translation: BAC71506.1

NCBI Reference Sequences

More...
RefSeqi
WP_010985225.1, NZ_JZJK01000090.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAC71506; BAC71506; SAVERM_3794

Database of genes from NCBI RefSeq genomes

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GeneIDi
41540862

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sma:SAVERM_3794

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA Translation: BAC71506.1
RefSeqiWP_010985225.1, NZ_JZJK01000090.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi227882.SAV_3794

Genome annotation databases

EnsemblBacteriaiBAC71506; BAC71506; SAVERM_3794
GeneIDi41540862
KEGGisma:SAVERM_3794

Phylogenomic databases

eggNOGiENOG4105DKF Bacteria
COG1060 LUCA
HOGENOMiHOG000020613
KOiK11779
OMAiHWVGHLN
OrthoDBi419725at2

Enzyme and pathway databases

UniPathwayiUPA00072
BioCyciSAVE227882:G1G23-3986-MONOMER

Family and domain databases

Gene3Di3.20.20.70, 2 hits
HAMAPiMF_01611 FO_synth_sub1, 1 hit
MF_01612 FO_synth_sub2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR019939 CofG_family
IPR019940 CofH_family
IPR006638 Elp3/MiaB/NifB
IPR034405 F420
IPR020050 FO_synthase_su2
IPR007197 rSAM
PANTHERiPTHR43076 PTHR43076, 1 hit
PfamiView protein in Pfam
PF04055 Radical_SAM, 2 hits
SFLDiSFLDF00293 ((2_3_4_5-tetrahydroxypentyl)a, 1 hit
SFLDF00294 7_8-didemethyl-8-hydroxy-5-dea, 1 hit
SFLDF00343 aminofutalosine_synthase_(mqnE, 1 hit
SFLDS00029 Radical_SAM, 1 hit
SMARTiView protein in SMART
SM00729 Elp3, 1 hit
TIGRFAMsiTIGR03550 F420_cofG, 1 hit
TIGR03551 F420_cofH, 1 hit
TIGR00423 TIGR00423, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFBIC_STRAW
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q82GV2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2003
Last modified: November 13, 2019
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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