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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64NucleophileUniRule annotation1
Binding sitei125SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Enzyme and pathway databases

BioCyciSAVE227882:G1G23-5215-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Ordered Locus Names:SAV_4955
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000428 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000574591 – 285tRNA pseudouridine synthase AAdd BLAST285

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227882.SAV_4955

Structurei

3D structure databases

ProteinModelPortaliQ82DM1
SMRiQ82DM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DI7 Bacteria
COG0101 LUCA
HOGENOMiHOG000248674
KOiK06173
OMAiFLYGMVR
OrthoDBiPOG091H010Q

Family and domain databases

Gene3Di3.30.70.660, 1 hit
HAMAPiMF_00171 TruA, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001406 PsdUridine_synth_TruA
IPR020097 PsdUridine_synth_TruA_a/b_dom
IPR020095 PsdUridine_synth_TruA_C
PANTHERiPTHR11142 PTHR11142, 1 hit
PfamiView protein in Pfam
PF01416 PseudoU_synth_1, 2 hits
PIRSFiPIRSF001430 tRNA_psdUrid_synth, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00071 hisT_truA, 1 hit

Sequencei

Sequence statusi: Complete.

Q82DM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDEVQPGFV RVRLDLSYDG TEFSGWAKQA AGRRTVQGEI EDALRTVTRS
60 70 80 90 100
GETTYELTVA GRTDAGVHAR GQVAHVDLPG ELWAEHQEKL LKRLAGRLPK
110 120 130 140 150
DVRVWSLTEA PSGFNARFSA IWRRYAYRVT DNTGGVDPLL RSHVLWHDWP
160 170 180 190 200
LDVDAMNEAA RRLVGEHDFA AYCKKREGAT TIRTLQELSL VRGDDGVITA
210 220 230 240 250
TVCADAFCHN MVRSLIGALL FVGDGHRGPD WPGKVLAVGV RDSAVHVVRP
260 270 280
HGLTLEEVGY PADELLAARN KEARNKRTLP AAGCC
Length:285
Mass (Da):31,388
Last modified:June 1, 2003 - v1
Checksum:iF9E6717D27BCD89C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA Translation: BAC72667.1
RefSeqiWP_010986361.1, NZ_JZJK01000077.1

Genome annotation databases

EnsemblBacteriaiBAC72667; BAC72667; SAVERM_4955
KEGGisma:SAVERM_4955

Similar proteinsi

Entry informationi

Entry nameiTRUA_STRAW
AccessioniPrimary (citable) accession number: Q82DM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: June 1, 2003
Last modified: July 18, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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