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Protein

Peptide deformylase 2

Gene

def2

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi104IronUniRule annotation1
Metal bindingi146IronUniRule annotation1
Active sitei147UniRule annotation1
Metal bindingi150IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciSAVE227882:G1G23-7449-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 2UniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDF 2UniRule annotation
Alternative name(s):
Polypeptide deformylase 2UniRule annotation
Gene namesi
Name:def2UniRule annotation
Ordered Locus Names:SAV_7126
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000428 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000828501 – 186Peptide deformylase 2Add BLAST186

Proteomic databases

PRIDEiQ826Q0

Interactioni

Protein-protein interaction databases

STRINGi227882.SAV_7126

Structurei

3D structure databases

ProteinModelPortaliQ826Q0
SMRiQ826Q0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107ZWG Bacteria
COG0242 LUCA
HOGENOMiHOG000243508
KOiK01462
OMAiDIVIWPH
OrthoDBiPOG091H02B0

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

Q826Q0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRHGSIPGTR GHVRPLALLG DPVLHAPCEE VTDHGPELAR LVEDMFATMY
60 70 80 90 100
AANGVGLAAN QIGVPLRVFV YDCPDDEDVR HVGHVVNPRL IEADGVVLRG
110 120 130 140 150
PEGCLSLPGL EAGTERYDRA VVEGFTTDGE PVRVLGTGWF ARCLQHECDH
160 170 180
LDGGVYVDRV SGWRHRRVMR QAARAPWNRQ RAPEPR
Length:186
Mass (Da):20,511
Last modified:June 1, 2003 - v1
Checksum:i6B0E069BC3331CC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA Translation: BAC74837.1
RefSeqiWP_010988521.1, NZ_JZJK01000085.1

Genome annotation databases

EnsemblBacteriaiBAC74837; BAC74837; SAVERM_7126
KEGGisma:SAVERM_7126

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA Translation: BAC74837.1
RefSeqiWP_010988521.1, NZ_JZJK01000085.1

3D structure databases

ProteinModelPortaliQ826Q0
SMRiQ826Q0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227882.SAV_7126

Proteomic databases

PRIDEiQ826Q0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC74837; BAC74837; SAVERM_7126
KEGGisma:SAVERM_7126

Phylogenomic databases

eggNOGiENOG4107ZWG Bacteria
COG0242 LUCA
HOGENOMiHOG000243508
KOiK01462
OMAiDIVIWPH
OrthoDBiPOG091H02B0

Enzyme and pathway databases

BioCyciSAVE227882:G1G23-7449-MONOMER

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDEF2_STRAW
AccessioniPrimary (citable) accession number: Q826Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: October 10, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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