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Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Chlamydophila caviae (strain GPIC)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. LL-diaminopimelate aminotransferase (dapL)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14SubstrateUniRule annotation1
Binding sitei41Substrate; via amide nitrogenUniRule annotation1
Binding sitei71Pyridoxal phosphateUniRule annotation1
Binding sitei105SubstrateUniRule annotation1
Binding sitei128Pyridoxal phosphateUniRule annotation1
Binding sitei128SubstrateUniRule annotation1
Binding sitei174Pyridoxal phosphateUniRule annotation1
Binding sitei174SubstrateUniRule annotation1
Binding sitei205Pyridoxal phosphateUniRule annotation1
Binding sitei244Pyridoxal phosphateUniRule annotation1
Binding sitei275Pyridoxal phosphateUniRule annotation1
Binding sitei275SubstrateUniRule annotation1
Binding sitei368SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciCCAV227941:G1G03-262-MONOMER
UniPathwayi
UPA00034;UER00466

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
Short name:
DAP-ATUniRule annotation
Short name:
DAP-aminotransferaseUniRule annotation
Short name:
LL-DAP-aminotransferaseUniRule annotation
Gene namesi
Name:dapLUniRule annotation
Ordered Locus Names:CCA_00249
OrganismiChlamydophila caviae (strain GPIC)
Taxonomic identifieri227941 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000002193 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003422241 – 395LL-diaminopimelate aminotransferaseAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227941.CCA00249

Structurei

3D structure databases

ProteinModelPortaliQ824A4
SMRiQ824A4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 105Pyridoxal phosphate bindingUniRule annotation2
Regioni233 – 235Pyridoxal phosphate bindingUniRule annotation3

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107QSS Bacteria
COG0436 LUCA
KOiK10206
OMAiTGTRCAF
OrthoDBiPOG091H0235

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019942 DapL/ALD1
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43144 PTHR43144, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03542 DAPAT_plant, 1 hit

Sequencei

Sequence statusi: Complete.

Q824A4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRNNNFSKL ETSYLFSSIR QKIRAFREAH PDVSIIDLSI GDTTQPLHTA
60 70 80 90 100
VMDTFTKSVQ KLGNPETYRG YGPELGLSTL REKLSEVFYQ GKVSPEEIFI
110 120 130 140 150
SDGAKMDIFR LLSLFGPGKT IAVQDPSYPV YIDTALLAGA KKVIKLPCRK
160 170 180 190 200
ETDFFPVIPQ GEEIDIFCLC SPNNPTGTVL TKEQLEELIT YANSHGSIIL
210 220 230 240 250
FDAAYSAFIS DPSLPKSIFE IPEARSCAIE INSFSKSLGF SGVRLGWNVV
260 270 280 290 300
PKDLRYSNGL PIIDDWKRFL HTTFNGASLP VQEAAITGAS LFPNLEAIAH
310 320 330 340 350
YRHNSSLLRE ALQKAEFSVY GGEHAPYLWV EVPKILPDED FFDFFLTQYH
360 370 380 390
IAITPGKGFG ACGKGYVRFS SLGKIEDIMA ACQRLTLTSV YDRMV
Length:395
Mass (Da):44,014
Last modified:June 1, 2003 - v1
Checksum:iFCF1151821290F5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015925 Genomic DNA Translation: AAP05000.1
RefSeqiWP_011006218.1, NC_003361.3

Genome annotation databases

EnsemblBacteriaiAAP05000; AAP05000; CCA_00249
KEGGicca:CCA_00249

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015925 Genomic DNA Translation: AAP05000.1
RefSeqiWP_011006218.1, NC_003361.3

3D structure databases

ProteinModelPortaliQ824A4
SMRiQ824A4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227941.CCA00249

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP05000; AAP05000; CCA_00249
KEGGicca:CCA_00249

Phylogenomic databases

eggNOGiENOG4107QSS Bacteria
COG0436 LUCA
KOiK10206
OMAiTGTRCAF
OrthoDBiPOG091H0235

Enzyme and pathway databases

UniPathwayi
UPA00034;UER00466

BioCyciCCAV227941:G1G03-262-MONOMER

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019942 DapL/ALD1
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43144 PTHR43144, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03542 DAPAT_plant, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDAPAT_CHLCV
AccessioniPrimary (citable) accession number: Q824A4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 1, 2003
Last modified: October 10, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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