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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Tropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei54NucleophileUniRule annotation1
Binding sitei114SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Ordered Locus Names:TW234
OrganismiTropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Taxonomic identifieri218496 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesTropheryma

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000574801 – 267tRNA pseudouridine synthase AAdd BLAST267

Proteomic databases

PRIDEiQ820Z2

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ820Z2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000248674
KOiK06173
OMAiFLYGMVR
OrthoDBiPOG091H010Q

Family and domain databases

Gene3Di3.30.70.660, 1 hit
HAMAPiMF_00171 TruA, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001406 PsdUridine_synth_TruA
IPR020097 PsdUridine_synth_TruA_a/b_dom
IPR020095 PsdUridine_synth_TruA_C
PANTHERiPTHR11142 PTHR11142, 1 hit
PfamiView protein in Pfam
PF01416 PseudoU_synth_1, 1 hit
PIRSFiPIRSF001430 tRNA_psdUrid_synth, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit

Sequencei

Sequence statusi: Complete.

Q820Z2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKTRYRLDV AYDGANFCGW APQPGLRTVG GLILDALRLI CSEPPDIVIA
60 70 80 90 100
ARTDAGVHAL QQVCHVDLIS SPDPVWLLHR LRSLLKSETD LHILSAVKAP
110 120 130 140 150
VNFHARFSAI GRRYVYRVID KRSSWYPQNR YFVYRVNAFL QDYRMRRAAS
160 170 180 190 200
GLIGLKDFGA FCKPRRMGST VRHLRQFEVI RQPDGQIHFF LESDAFCHSM
210 220 230 240 250
VRNLVGSLIE VGRGALTLQD LFCYTKIAKR TPKIPTLPPH ALTLIGIDYP
260
QEHLFECQNR KTRQKRT
Length:267
Mass (Da):30,590
Last modified:June 1, 2003 - v1
Checksum:i1787DD2D175F60F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX251410 Genomic DNA Translation: CAD66911.1
RefSeqiWP_011096192.1, NC_004551.1

Genome annotation databases

EnsemblBacteriaiCAD66911; CAD66911; TW234
KEGGitws:TW234

Similar proteinsi

Entry informationi

Entry nameiTRUA_TROW8
AccessioniPrimary (citable) accession number: Q820Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: June 1, 2003
Last modified: July 18, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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