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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCBUR227377:G1G0B-137-MONOMER
UniPathwayi
UPA00219

Protein family/group databases

CAZyiGT28 Glycosyltransferase Family 28

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:CBU_0135
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001091691 – 358UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseAdd BLAST358

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_0135

Structurei

3D structure databases

ProteinModelPortaliQ820X3
SMRiQ820X3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVQ Bacteria
COG0707 LUCA
HOGENOMiHOG000218321
KOiK02563
OMAiHQTKNAM

Family and domain databases

CDDicd03785 GT1_MurG, 1 hit
HAMAPiMF_00033 MurG, 1 hit
InterProiView protein in InterPro
IPR006009 GlcNAc_MurG
IPR007235 Glyco_trans_28_C
IPR004276 GlycoTrans_28_N
PfamiView protein in Pfam
PF04101 Glyco_tran_28_C, 1 hit
PF03033 Glyco_transf_28, 1 hit
TIGRFAMsiTIGR01133 murG, 1 hit

Sequencei

Sequence statusi: Complete.

Q820X3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRILIIAGG TGGHIFPALA VARELREQEV DVQWLGVKGG LEEKLVPDSF
60 70 80 90 100
PLHLIQIKAF RGKRGLQQLL MPLRLVRAVF QAYRIIRQFK PDVILGMGGY
110 120 130 140 150
VAGPGGLAAW ITRTPLIIHE QNSIPGLTNR VLAKMAKFIL QGFPDTFPQN
160 170 180 190 200
RKVITTGNPV RTELVKMPLP QVRLAARRGP LRILVLGGSQ GARSINQKML
210 220 230 240 250
AALSSYPRSE EIAVWHQTGQ RDFEFIQKEY EKIKIEAKVD NFISDMAGAY
260 270 280 290 300
GWADLVVCRA GALTVCEIAS VGVASIFIPY PHAVDNHQFH NARFLEQAGA
310 320 330 340 350
AIIISEESLT ETDLMRWFEQ FAQDRDRLLT MAENARKLAK PEAVQRVIAQ

CKKFYAAR
Length:358
Mass (Da):39,974
Last modified:June 1, 2003 - v1
Checksum:i5BF7E97212E90AB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA Translation: AAO89699.1
RefSeqiNP_819185.1, NC_002971.3
WP_005769484.1, NZ_LM994641.1

Genome annotation databases

EnsemblBacteriaiAAO89699; AAO89699; CBU_0135
GeneIDi1208006
KEGGicbu:CBU_0135
PATRICifig|227377.7.peg.137

Similar proteinsi

Entry informationi

Entry nameiMURG_COXBU
AccessioniPrimary (citable) accession number: Q820X3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: June 1, 2003
Last modified: February 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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