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Protein

tRNA (guanine-N(1)-)-methyltransferase

Gene

trmD

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically methylates guanosine-37 in various tRNAs.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N1-methylguanine(37) in tRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei114S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCBUR227377:G1G0B-439-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(1)-)-methyltransferaseUniRule annotation (EC:2.1.1.228UniRule annotation)
Alternative name(s):
M1G-methyltransferaseUniRule annotation
tRNA [GM37] methyltransferaseUniRule annotation
Gene namesi
Name:trmDUniRule annotation
Ordered Locus Names:CBU_0443
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000603671 – 246tRNA (guanine-N(1)-)-methyltransferaseAdd BLAST246

Proteomic databases

PRIDEiQ820X1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_0443

Structurei

3D structure databases

ProteinModelPortaliQ820X1
SMRiQ820X1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni134 – 139S-adenosyl-L-methionine bindingUniRule annotation6

Sequence similaritiesi

Belongs to the RNA methyltransferase TrmD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D6X Bacteria
COG0336 LUCA
HOGENOMiHOG000016242
KOiK00554
OMAiILCGHYK

Family and domain databases

Gene3Di1.10.1270.20, 1 hit
3.40.1280.10, 1 hit
HAMAPiMF_00605 TrmD, 1 hit
InterProiView protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR002649 tRNA_m1G_MeTrfase_bac
IPR023148 tRNA_m1G_MeTrfase_C
IPR029026 tRNA_m1G_MTases_N
IPR016009 tRNA_MeTrfase_TRMD/TRM10
PANTHERiPTHR32125:SF1 PTHR32125:SF1, 1 hit
PfamiView protein in Pfam
PF01746 tRNA_m1G_MT, 1 hit
PIRSFiPIRSF000386 tRNA_mtase, 1 hit
SUPFAMiSSF75217 SSF75217, 1 hit
TIGRFAMsiTIGR00088 trmD, 1 hit

Sequencei

Sequence statusi: Complete.

Q820X1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLIIGVITL FPQMFDALKS GVIGRALKQD RLTLSCWNPR DYATDPHRTV
60 70 80 90 100
DDRPYGGGPG MVMKFEPLAL ALKAAKAQLG ENTKVIHLTP QGKLLTQAIV
110 120 130 140 150
REKIHASPLI LLAGRYEGID ERLIEAEVDE EWSIGDYILS GGELPAMVLI
160 170 180 190 200
DAMTRLLPGV LGHKDSASQD SFTAGLLDYP HYTRPEKIAD RPVPSVLLSG
210 220 230 240
DHEAISRWRL KQSLGRTWQR RQDLIKRRSL SENEQRLLDE FFEESS
Length:246
Mass (Da):27,611
Last modified:June 1, 2003 - v1
Checksum:i6F82538240A955B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA Translation: AAO89994.1
RefSeqiNP_819480.1, NC_002971.3
WP_010957578.1, NC_002971.4

Genome annotation databases

EnsemblBacteriaiAAO89994; AAO89994; CBU_0443
GeneIDi1208327
KEGGicbu:CBU_0443
PATRICifig|227377.7.peg.434

Similar proteinsi

Entry informationi

Entry nameiTRMD_COXBU
AccessioniPrimary (citable) accession number: Q820X1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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