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Protein

Undecaprenyl-diphosphatase 1

Gene

uppP1

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 1UniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance protein 1UniRule annotation
Undecaprenyl pyrophosphate phosphatase 1UniRule annotation
Gene namesi
Name:uppP1UniRule annotation
Synonyms:bacA-1, bacA1, upk1
Ordered Locus Names:BA_0283, GBAA_0283, BAS0269
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalUniRule annotationAdd BLAST21
Transmembranei42 – 62HelicalUniRule annotationAdd BLAST21
Transmembranei84 – 104HelicalUniRule annotationAdd BLAST21
Transmembranei108 – 128HelicalUniRule annotationAdd BLAST21
Transmembranei184 – 204HelicalUniRule annotationAdd BLAST21
Transmembranei217 – 237HelicalUniRule annotationAdd BLAST21
Transmembranei245 – 265HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001510851 – 265Undecaprenyl-diphosphatase 1Add BLAST265

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS0269

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218356
KOiK06153
OMAiDPDITAF

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

Q81VC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDIITAFIL GIVEGLAEFL PISSTGHLIL VGHLLGFEGE RAKTFEIVIQ
60 70 80 90 100
LGAILAIAIL YHKRLVSLCN LKPLLRKEKK FNAFHVFLGV FPAVVAGLLL
110 120 130 140 150
HDVIKTYLFQ PYTVVIGLVA GAILMIFAEV KKQEATSYSL DDLTYRQALT
160 170 180 190 200
IGLFQCLAVY PGFSRAGSTI SGGLLAKVNY KTASEFSFLI ALPVMVGATG
210 220 230 240 250
LDLLKSWTYL SVDDIPMFAV GFITSFIVAM LAVVTFLKLL EKIGLKPFAY
260
YRILLAILFT VFVLL
Length:265
Mass (Da):29,032
Last modified:June 1, 2003 - v1
Checksum:i4FF3F551E13B327E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP24319.1
AE017334 Genomic DNA Translation: AAT29368.1
AE017225 Genomic DNA Translation: AAT52601.1
RefSeqiNP_842833.1, NC_003997.3
WP_001280040.1, NZ_QANP01000020.1
YP_026550.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP24319; AAP24319; BA_0283
AAT29368; AAT29368; GBAA_0283
AAT52601; AAT52601; BAS0269
GeneIDi1085701
2851216
KEGGiban:BA_0283
bar:GBAA_0283
bat:BAS0269
PATRICifig|198094.11.peg.274

Similar proteinsi

Entry informationi

Entry nameiUPPP1_BACAN
AccessioniPrimary (citable) accession number: Q81VC9
Secondary accession number(s): Q6I4D0, Q6KY33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: July 18, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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