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Protein

Stage IV sporulation protein A

Gene

spoIVA

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

ATPase. Has a role at an early stage in the morphogenesis of the spore coat outer layers. Directs the assembly of the coat and exosporium to an area around the forespore.By similarity1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

  • exosporium assembly Source: UniProtKB
  • spore wall assembly Source: UniProtKB
  • sporulation resulting in formation of a cellular spore Source: UniProtKB

Keywordsi

Molecular functionHydrolase
Biological processSporulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Stage IV sporulation protein AImported (EC:3.6.1.3By similarity)
Alternative name(s):
Coat morphogenetic protein SpoIVA1 Publication
Gene namesi
Name:spoIVAImported
Ordered Locus Names:BA_1530, BAS1419, GBAA_1530
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Defective in formation of mature forespores. Fails to progress beyond very early stages of sporulation. Forespores lack the germ cell wall or cortex and the mother cells are filled with swirls of electron-dense material.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004222371 – 492Stage IV sporulation protein AAdd BLAST492

Expressioni

Developmental stagei

Expressed in early onset of sporulation.1 Publication

Interactioni

Protein-protein interaction databases

IntActiQ81SW4, 6 interactors
STRINGi260799.BAS1419

Structurei

3D structure databases

SMRiQ81SW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi24 – 31Walker A motif; involved in ATP-bindingSequence analysisCurated8

Phylogenomic databases

eggNOGiENOG4105DXU Bacteria
ENOG410XQ51 LUCA
HOGENOMiHOG000058353
KOiK06398
OMAiRMVTTPW

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR014201 Spore_IV_A
PfamiView protein in Pfam
PF09547 Spore_IV_A, 1 hit
PIRSFiPIRSF007466 SpoIVA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR02836 spore_IV_A, 1 hit

Sequencei

Sequence statusi: Complete.

Q81SW4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKVDIFKDI AERTGGDIYF GVVGAVRTGK STFIKKFMEL VVIPNIENES
60 70 80 90 100
DRQRAQDELP QSAAGRTIMT TEPKFVPNQA VSIEVDEGLE VNIRLVDCVG
110 120 130 140 150
YTVPGAKGYE DENGPRMINT PWYEEPIPFH EAAEIGTRKV IQEHSTIGVV
160 170 180 190 200
ITTDGTIGEI PRRDYIEAEE RVVNELKEVG KPFIMIINTV QPYHPDTEQL
210 220 230 240 250
RQSLSEEYDI PVIAMSVESL RETDVYNVLR EALFEFPVLE VNVNLPSWVM
260 270 280 290 300
VLNEGHWLRQ SYQEAVQETV KDIKRLRDVD RVVWQFSQYE FIDRASLAGI
310 320 330 340 350
DMGQGVAEID LYAPDELYDQ ILKEVVGVEI RGKDHLLKLM LDLSHAKIEY
360 370 380 390 400
DQVADALRMV KQTGYGVAAP ALADMSLDEP EIIRHGSRFG VKLKAVAPSI
410 420 430 440 450
HMIKVDVEST FEPIIGTEKQ SEELVRYLMQ DFEDDPLSIW NSDIFGRSLS
460 470 480 490
SIVREGIQAK LSLMPENARY KLKETLERII NEGSGGLIAI IL
Length:492
Mass (Da):55,613
Last modified:June 1, 2003 - v1
Checksum:iB9964465278D4137
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP25467.1
AE017334 Genomic DNA Translation: AAT30628.2
AE017225 Genomic DNA Translation: AAT53739.1
RefSeqiNP_843981.1, NC_003997.3
WP_000416519.1, NZ_QANP01000005.1
YP_027688.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP25467; AAP25467; BA_1530
AAT30628; AAT30628; GBAA_1530
AAT53739; AAT53739; BAS1419
GeneIDi1087217
2849170
31630931
KEGGiban:BA_1530
bar:GBAA_1530
bat:BAS1419
PATRICifig|198094.11.peg.1502

Similar proteinsi

Entry informationi

Entry nameiSP4A_BACAN
AccessioniPrimary (citable) accession number: Q81SW4
Secondary accession number(s): E9QV53
, E9QV54, Q6I143, Q6KUZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: June 1, 2003
Last modified: July 18, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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