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Protein

Methionine aminopeptidase

Gene

maP3

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Co2+UniRule annotation, Zn2+UniRule annotation, Mn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92SubstrateUniRule annotation1
Metal bindingi109Divalent metal cation 1UniRule annotation1
Metal bindingi120Divalent metal cation 1UniRule annotation1
Metal bindingi120Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi182Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation1
Binding sitei189SubstrateUniRule annotation1
Metal bindingi216Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi248Divalent metal cation 1UniRule annotation1
Metal bindingi248Divalent metal cation 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cellular protein modification process Source: TIGR
  • protein initiator methionine removal Source: UniProtKB-UniRule

Keywordsi

Molecular functionAminopeptidaseUniRule annotationImported, Hydrolase, Protease
LigandMetal-bindingUniRule annotation

Protein family/group databases

MEROPSiM24.036

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidaseUniRule annotation (EC:3.4.11.18UniRule annotation)
Short name:
MAPUniRule annotation
Short name:
MetAPUniRule annotation
Alternative name(s):
Peptidase MUniRule annotation
Gene namesi
Name:maP3Imported
Synonyms:mapUniRule annotation
Ordered Locus Names:GBAA_5601Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

IntActiQ81JU4, 7 interactors
STRINGi260799.BAS5204

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105CA1 Bacteria
COG0024 LUCA
HOGENOMiHOG000030426
KOiK01265

Family and domain databases

CDDicd01086 MetAP1, 1 hit
HAMAPiMF_01974 MetAP_1, 1 hit
InterProiView protein in InterPro
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001714 Pept_M24_MAP
IPR002467 Pept_M24A_MAP1
PfamiView protein in Pfam
PF00557 Peptidase_M24, 1 hit
PRINTSiPR00599 MAPEPTIDASE
SUPFAMiSSF55920 SSF55920, 1 hit
TIGRFAMsiTIGR00500 met_pdase_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q81JU4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIQSGKIYIR GRTVVFMIIR NEQDLEGLRK IGRIVALARE EMKKEAKPGM
60 70 80 90 100
TTKELDLIGK KVLDEHGAIS APEKEYDFPG VTCISVNEEV AHGIPGDRVL
110 120 130 140 150
KEGDLVNVDV SAALDGYYAD TGISFVLGED EAKEKLCQAA VDAFWAAMKK
160 170 180 190 200
VKAGSKQNQI GRAVSNFAHK NGYNVIQNLT GHGIGLSLHE APNHILSYFD
210 220 230 240 250
PMDNALLKDG LVIAVEPFIS MKADHIIERG DDGWTFVTPD KSLVAQCEHT
260
VVVTRGEPII LTEI
Length:264
Mass (Da):28,912
Last modified:June 1, 2003 - v1
Checksum:iAC21D93C604858DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017334 Genomic DNA Translation: AAT34747.2
RefSeqiWP_002096176.1, NZ_QPKQ01000006.1

Genome annotation databases

EnsemblBacteriaiAAT34747; AAT34747; GBAA_5601
KEGGibar:GBAA_5601

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017334 Genomic DNA Translation: AAT34747.2
RefSeqiWP_002096176.1, NZ_QPKQ01000006.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ81JU4, 7 interactors
STRINGi260799.BAS5204

Protein family/group databases

MEROPSiM24.036

Protocols and materials databases

DNASUi1085302
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT34747; AAT34747; GBAA_5601
KEGGibar:GBAA_5601

Phylogenomic databases

eggNOGiENOG4105CA1 Bacteria
COG0024 LUCA
HOGENOMiHOG000030426
KOiK01265

Family and domain databases

CDDicd01086 MetAP1, 1 hit
HAMAPiMF_01974 MetAP_1, 1 hit
InterProiView protein in InterPro
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001714 Pept_M24_MAP
IPR002467 Pept_M24A_MAP1
PfamiView protein in Pfam
PF00557 Peptidase_M24, 1 hit
PRINTSiPR00599 MAPEPTIDASE
SUPFAMiSSF55920 SSF55920, 1 hit
TIGRFAMsiTIGR00500 met_pdase_I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ81JU4_BACAN
AccessioniPrimary (citable) accession number: Q81JU4
Secondary accession number(s): E9QTT6, Q6KJS1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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