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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
Ordered Locus Names:BA_5648, GBAA_5648, BAS5250
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001760561 – 225Uracil-DNA glycosylaseAdd BLAST225

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS5250

Structurei

3D structure databases

ProteinModelPortaliQ81JQ4
SMRiQ81JQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5S Bacteria
COG0692 LUCA
HOGENOMiHOG000229528
KOiK03648
OMAiQANGLCF

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q81JQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHVLKNDWG PLLAPEFEKE YYRELDVFLK EEYSTHVVYP KIEDIFNALE
60 70 80 90 100
YTSYENTKVV ILGQDPYHGP NQAHGLSFSV QPGVKTPPSL LNMYKELRDE
110 120 130 140 150
YGYDIPNNGY LVKWAEQGVL LLNTVLTVRQ GEANSHKGKG WEHFTDRVIE
160 170 180 190 200
LLNEREKPVI FILWGRHAQA KKKLITNPNH QIIESVHPSP LSARRGFFGS
210 220
KPYSKVNTIL ANMGEGEIDW EIPNL
Length:225
Mass (Da):25,918
Last modified:June 1, 2003 - v1
Checksum:i8FDC19B5D4D20F75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP29282.1
AE017334 Genomic DNA Translation: AAT34799.1
AE017225 Genomic DNA Translation: AAT57538.1
RefSeqiNP_847796.1, NC_003997.3
WP_000683472.1, NZ_QANP01000001.1
YP_031488.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP29282; AAP29282; BA_5648
AAT34799; AAT34799; GBAA_5648
AAT57538; AAT57538; BAS5250
GeneIDi1085374
2850573
KEGGiban:BA_5648
bar:GBAA_5648
bat:BAS5250
PATRICifig|198094.11.peg.5608

Similar proteinsi

Entry informationi

Entry nameiUNG_BACAN
AccessioniPrimary (citable) accession number: Q81JQ4
Secondary accession number(s): Q6HQA0, Q6KJN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2003
Last modified: July 18, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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