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Entry version 102 (08 May 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Lactate utilization protein B

Gene

lutB

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate.UniRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi311Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi314Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi317Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi321Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi364Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi367Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi371Iron-sulfur 1 (4Fe-4S)UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lactate utilization protein BUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lutBUniRule annotation
Ordered Locus Names:BC_1304
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri226900 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001417 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003839711 – 473Lactate utilization protein BAdd BLAST473

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q81GA4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q81GA4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini302 – 3324Fe-4S ferredoxin-type 1UniRule annotationAdd BLAST31
Domaini351 – 3804Fe-4S ferredoxin-type 2UniRule annotationAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LutB/YkgF family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1139 LUCA

KEGG Orthology (KO)

More...
KOi
K18929

Identification of Orthologs from Complete Genome Data

More...
OMAi
HCPVYDK

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10420, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_02103 LutB, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004452 4Fe-4S-bd
IPR024569 4Fe-4S-bd_C
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR024185 FTHF_cligase-like_sf
IPR009051 Helical_ferredxn
IPR003741 LUD_dom
IPR022825 LutB
IPR037171 NagB/RpiA_transferase-like

The PANTHER Classification System

More...
PANTHERi
PTHR47153 PTHR47153, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11870 DUF3390, 1 hit
PF13183 Fer4_8, 1 hit
PF02589 LUD_dom, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100950 SSF100950, 1 hit
SSF46548 SSF46548, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00273 TIGR00273, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q81GA4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMKISEKKF NDRVGDGIQD SFMRGAVSSA QTRLYTNRLK AADELGNWEE
60 70 80 90 100
WRELGEQIRQ HTLENLDYYL MQLSENVSKR GGHVYFAKTK EEAAKYIQDV
110 120 130 140 150
AKKKQAKKVV KSKSMVTEEI SMNHALEEIG CEVLESDLGE YILQVDNDPP
160 170 180 190 200
SHIIAPALHK NRTQIRDVFK EKLGYENSDD PYEMTKFVRK QLREKFMDAE
210 220 230 240 250
IGVTGCNFAV ANTGSLCLVT NEGNADLVMS IPKTQIAVMG MERMVPTMEE
260 270 280 290 300
LDVLVGLLCR SAVGQKLTSY VTVAGPIQEE EVDGPEEFHL VVVDNGRSQI
310 320 330 340 350
LGSEFRSVLQ CIRCAACVNV CPVYRHVGGH SYGSIYSGPI GAVLTPLLGG
360 370 380 390 400
YDDYKELPYA SSLCGACTEA CPVKIPLHDL LLKHRQVIVE QEGRAPLAEK
410 420 430 440 450
LAMKMFSMGA SSAALYKMGS KMAPAAMSPF TSGNRVSKGV GPLKNWTDIR
460 470
EFPAPSKERF RDWYKDHKKG GDK
Length:473
Mass (Da):52,627
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6286C61DFDA81864
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE016877 Genomic DNA Translation: AAP08287.1

NCBI Reference Sequences

More...
RefSeqi
NP_831086.1, NC_004722.1
WP_000061930.1, NC_004722.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAP08287; AAP08287; BC_1304

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1203653
29683109

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bce:BC1304

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|226900.8.peg.1277

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA Translation: AAP08287.1
RefSeqiNP_831086.1, NC_004722.1
WP_000061930.1, NC_004722.1

3D structure databases

SMRiQ81GA4
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ81GA4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP08287; AAP08287; BC_1304
GeneIDi1203653
29683109
KEGGibce:BC1304
PATRICifig|226900.8.peg.1277

Phylogenomic databases

eggNOGiCOG1139 LUCA
KOiK18929
OMAiHCPVYDK

Family and domain databases

Gene3Di3.40.50.10420, 1 hit
HAMAPiMF_02103 LutB, 1 hit
InterProiView protein in InterPro
IPR004452 4Fe-4S-bd
IPR024569 4Fe-4S-bd_C
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR024185 FTHF_cligase-like_sf
IPR009051 Helical_ferredxn
IPR003741 LUD_dom
IPR022825 LutB
IPR037171 NagB/RpiA_transferase-like
PANTHERiPTHR47153 PTHR47153, 1 hit
PfamiView protein in Pfam
PF11870 DUF3390, 1 hit
PF13183 Fer4_8, 1 hit
PF02589 LUD_dom, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
SSF46548 SSF46548, 1 hit
TIGRFAMsiTIGR00273 TIGR00273, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLUTB_BACCR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q81GA4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 1, 2003
Last modified: May 8, 2019
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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