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Protein

Arsenate reductase

Gene

arsC

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)].UniRule annotation

Catalytic activityi

Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11NucleophileUniRule annotation1
Active sitei83NucleophileUniRule annotation1
Active sitei90NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processArsenical resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenate reductaseUniRule annotation (EC:1.20.4.4UniRule annotation)
Gene namesi
Name:arsCUniRule annotation
Ordered Locus Names:BC_3152
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000001417 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001625141 – 134Arsenate reductaseAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi11 ↔ 83Redox-active; alternateUniRule annotation
Disulfide bondi83 ↔ 90Redox-active; alternateUniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi226900.BC3152

Structurei

3D structure databases

ProteinModelPortaliQ81BK3
SMRiQ81BK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4108SY2 Bacteria
COG0394 LUCA
KOiK03741
OMAiCSHADSV

Family and domain databases

HAMAPiMF_01624 Arsenate_reduct, 1 hit
InterProiView protein in InterPro
IPR014064 Arsenate_reductase_ArsC
IPR023485 Ptyr_pPase
IPR036196 Ptyr_pPase_sf
PfamiView protein in Pfam
PF01451 LMWPc, 1 hit
SMARTiView protein in SMART
SM00226 LMWPc, 1 hit
SUPFAMiSSF52788 SSF52788, 1 hit
TIGRFAMsiTIGR02691 arsC_pI258_fam, 1 hit

Sequencei

Sequence statusi: Complete.

Q81BK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENKKTIYFL CTGNSCRSQM AEAWGKQYLG DKWNVYSAGM EAHGVNPNAI
60 70 80 90 100
KAMNEVNIDI TNQTSDIIDA NILNSADLVV TLCSHADSVC PSTPPHVNRV
110 120 130
HWGFDDPAGK EWSEFQRVRD EIGERIKRFS KTGE
Length:134
Mass (Da):15,020
Last modified:June 1, 2003 - v1
Checksum:iD50182339306175D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA Translation: AAP10094.1
RefSeqiNP_832893.1, NC_004722.1
WP_000428363.1, NC_004722.1

Genome annotation databases

EnsemblBacteriaiAAP10094; AAP10094; BC_3152
GeneIDi1205499
KEGGibce:BC3152
PATRICifig|226900.8.peg.3234

Similar proteinsi

Entry informationi

Entry nameiARSC_BACCR
AccessioniPrimary (citable) accession number: Q81BK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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