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Protein

Agmatinase

Gene

speB

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of putrescine from agmatine.By similarity

Catalytic activityi

Agmatine + H2O = putrescine + urea.

Cofactori

Mn2+PROSITE-ProRule annotation

Pathwayi: putrescine biosynthesis via agmatine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from agmatine.
Proteins known to be involved in this subpathway in this organism are:
  1. Agmatinase (speB)
This subpathway is part of the pathway putrescine biosynthesis via agmatine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from agmatine, the pathway putrescine biosynthesis via agmatine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi112ManganesePROSITE-ProRule annotation1
Metal bindingi135ManganesePROSITE-ProRule annotation1
Metal bindingi137ManganesePROSITE-ProRule annotation1
Metal bindingi139ManganesePROSITE-ProRule annotation1
Metal bindingi216ManganesePROSITE-ProRule annotation1
Metal bindingi218ManganesePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPolyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00534; UER00287

Names & Taxonomyi

Protein namesi
Recommended name:
Agmatinase (EC:3.5.3.11)
Alternative name(s):
Agmatine ureohydrolase
Short name:
AUH
Gene namesi
Name:speB
Ordered Locus Names:BC_5370
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000001417 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001737261 – 290AgmatinaseAdd BLAST290

Interactioni

Protein-protein interaction databases

STRINGi226900.BC5370

Structurei

3D structure databases

ProteinModelPortaliQ814Q2
SMRiQ814Q2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family. Agmatinase subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105CYW Bacteria
COG0010 LUCA
KOiK01480
OMAiDTYFGAE

Family and domain databases

InterProiView protein in InterPro
IPR005925 Agmatinase-rel
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
IPR020855 Ureohydrolase_Mn_BS
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01230 agmatinase, 1 hit
PROSITEiView protein in PROSITE
PS01053 ARGINASE_1, 1 hit
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q814Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFDEAYSGK VFIKSHPSFE ESKVVIYGMP MDWTVSYRPG SRFGPARIRE
60 70 80 90 100
VSIGLEEYSP YLDRELEEVK YFDAGDIPLP FGNAQRSLDM IEEYVSKLLD
110 120 130 140 150
ADKFPLGLGG EHLVSWPIFK AMAKKYPDLA IIHMDAHTDL RESYEGEPLS
160 170 180 190 200
HSTPIRKVCD LIGPENVYSF GIRSGMKEEF EWAKEVGMNL YKFDVLEPLK
210 220 230 240 250
EVLPKLAGRP VYVTIDIDVL DPAHAPGTGT LEAGGITSKE LLDSIVAIAN
260 270 280 290
SNINVVGADL VEVAPVYDHS DQTPVAASKF VREMLLGWVK
Length:290
Mass (Da):32,389
Last modified:June 1, 2003 - v1
Checksum:iD538E9EBDE734B5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA Translation: AAP12232.1
RefSeqiNP_835031.1, NC_004722.1
WP_001209831.1, NC_004722.1

Genome annotation databases

EnsemblBacteriaiAAP12232; AAP12232; BC_5370
GeneIDi1207710
31627096
KEGGibce:BC5370
PATRICifig|226900.8.peg.5545

Similar proteinsi

Entry informationi

Entry nameiSPEB_BACCR
AccessioniPrimary (citable) accession number: Q814Q2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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