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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
Ordered Locus Names:BC_5398
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000001417 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001760581 – 225Uracil-DNA glycosylaseAdd BLAST225

Interactioni

Protein-protein interaction databases

STRINGi226900.BC5398

Structurei

3D structure databases

ProteinModelPortaliQ814M9
SMRiQ814M9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5S Bacteria
COG0692 LUCA
KOiK03648
OMAiQANGLCF

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q814M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENVLKNDWE PLLAPEFEKE YYLTLSSFLT EEYSTHVVYP KVEDIFNALQ
60 70 80 90 100
YTSYENTKVV ILGQDPYHGP NQAHGLSFSV QPGVKTPPSL LNMYKELRDE
110 120 130 140 150
YGYEIPNNGY LVKWAEQGVL LLNTVLTVRQ GEANSHKGKG WEHFTDRVIE
160 170 180 190 200
LLNEREKPVI FILWGRHAQA KKKLITNPNH HIIESVHPSP LSARRGFFGS
210 220
KPYSKINTIL ANMGEREIDW EIPNL
Length:225
Mass (Da):25,951
Last modified:June 1, 2003 - v1
Checksum:iFE04AECF2F9B59A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA Translation: AAP12260.1
RefSeqiNP_835059.1, NC_004722.1
WP_000432519.1, NC_004722.1

Genome annotation databases

EnsemblBacteriaiAAP12260; AAP12260; BC_5398
GeneIDi1207738
KEGGibce:BC5398
PATRICifig|226900.8.peg.5576

Similar proteinsi

Entry informationi

Entry nameiUNG_BACCR
AccessioniPrimary (citable) accession number: Q814M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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