Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Retina-specific copper amine oxidase

Gene

Aoc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina (By similarity).By similarity

Catalytic activityi

RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2.By similarity

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei381Proton acceptorBy similarity1
Active sitei466Schiff-base intermediate with substrate; via topaquinoneBy similarity1
Metal bindingi517Copper; via tele nitrogenBy similarity1
Metal bindingi519Copper; via tele nitrogenBy similarity1
Metal bindingi526Calcium 1By similarity1
Metal bindingi527Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi528Calcium 1By similarity1
Metal bindingi569Calcium 2By similarity1
Metal bindingi660Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi662Calcium 2By similarity1
Metal bindingi664Calcium 2By similarity1
Metal bindingi670Calcium 1By similarity1
Metal bindingi671Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi681Copper; via pros nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCatecholamine metabolism
LigandCalcium, Copper, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211945 Phase I - Functionalization of compounds

Names & Taxonomyi

Protein namesi
Recommended name:
Retina-specific copper amine oxidase (EC:1.4.3.21By similarity)
Short name:
RAO
Alternative name(s):
Amine oxidase [copper-containing]
Gene namesi
Name:Aoc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2668431 Aoc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000003567233 – 757Retina-specific copper amine oxidaseBy similarityAdd BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi133N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi226N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi399 ↔ 425By similarity
Modified residuei4662',4',5'-topaquinoneBy similarity1
Glycosylationi589N-linked (GlcNAc...) (complex) asparagineBy similarity1
Glycosylationi663N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi731 ↔ 738By similarity
Disulfide bondi745InterchainBy similarity

Post-translational modificationi

Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, TPQ

Proteomic databases

MaxQBiQ812C9
PaxDbiQ812C9
PRIDEiQ812C9

PTM databases

iPTMnetiQ812C9
PhosphoSitePlusiQ812C9

Expressioni

Tissue specificityi

Significantly much highly expressed in retina.

Gene expression databases

BgeeiENSMUSG00000078651 Expressed in 21 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ812C9 baseline and differential

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Forms a heterodimer with AOC3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040255

Structurei

3D structure databases

ProteinModelPortaliQ812C9
SMRiQ812C9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni379 – 389Substrate bindingBy similarityAdd BLAST11
Regioni463 – 468Substrate bindingBy similarity6
Regioni575 – 582Heparin-bindingBy similarity8

Sequence similaritiesi

Belongs to the copper/topaquinone oxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1186 Eukaryota
COG3733 LUCA
GeneTreeiENSGT00510000046461
HOGENOMiHOG000233919
HOVERGENiHBG004164
InParanoidiQ812C9
KOiK00276
OMAiNANWARY
OrthoDBiEOG091G02WY
TreeFamiTF314750

Family and domain databases

Gene3Di2.70.98.20, 1 hit
InterProiView protein in InterPro
IPR032952 AOC2
IPR000269 Cu_amine_oxidase
IPR015798 Cu_amine_oxidase_C
IPR036460 Cu_amine_oxidase_C_sf
IPR016182 Cu_amine_oxidase_N-reg
IPR015800 Cu_amine_oxidase_N2
IPR015802 Cu_amine_oxidase_N3
PANTHERiPTHR10638 PTHR10638, 1 hit
PTHR10638:SF4 PTHR10638:SF4, 1 hit
PfamiView protein in Pfam
PF01179 Cu_amine_oxid, 1 hit
PF02727 Cu_amine_oxidN2, 1 hit
PF02728 Cu_amine_oxidN3, 1 hit
PRINTSiPR00766 CUDAOXIDASE
SUPFAMiSSF49998 SSF49998, 1 hit
SSF54416 SSF54416, 2 hits
PROSITEiView protein in PROSITE
PS01164 COPPER_AMINE_OXID_1, 1 hit
PS01165 COPPER_AMINE_OXID_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q812C9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLKVLLLLL GLSFLTVFAL VYVLLTRQGS FSQSPRCPSI PPRIHPWTHP
60 70 80 90 100
SQSQLFADLT PEELTAVMSF LTKHLGPGLV DAAQARPSDN CVFSVELQLP
110 120 130 140 150
AKAAALAHLD RGGPPPVREA LAIIFFGGQP KPNVSELVVG PLPHPSYMRD
160 170 180 190 200
VTVERHGGPL PYYRRPMQKT EFVQIWRHLK EVELPKAPTF LASVLNYNGS
210 220 230 240 250
TLAPLHSTAS GFHAGDRATW IALYHNISGL GVFLHPVGLE LLLDHGALDP
260 270 280 290 300
ADWVVQQVFY LGHYYADLAQ LEWEFKVGRL EVIRVPLPTP GGASSLRPRV
310 320 330 340 350
TPDPPLPPLQ FSLQGPQYNI QGNSVTSPLW TFTFGHGVFS GLRIFDIRFK
360 370 380 390 400
GERVAYEVSV QECLTVYGAD SPKTMTIRYL DSSYGLGLNS RALVRGVDCP
410 420 430 440 450
YQATMVDIHV LVGTGSVQLL PGAVCVFEEA QGLPLRRHHN GIGGHFYGGL
460 470 480 490 500
ASSSLVVRSV SSVGNYDYIW DFMLHPTGAL EARVHATGYI NTAFMSGGAE
510 520 530 540 550
SLLFGNRVGE RVLGAVHTHA FHFKLDLDVA GLKNWVIAED AVFKPVAAPW
560 570 580 590 600
NPELQLQRPQ LTRQVLSRED LAAFPWGSPL PRYLYLATNQ TNAWGHQRGY
610 620 630 640 650
RIQIHSPPGV HVPLESSEER ALSWGRYQLV VTQRKEAEPH SSSIYYQNDM
660 670 680 690 700
RSPATVFADF INNETLLGED LVAWVTASFL HIPHAEDIPN TVTVGNRVGF
710 720 730 740 750
LLRPYNFFNE DPSIFSPGSV YFERDQDAGL CSINPVACTQ QLADCVPNLP

SFSYEGL
Length:757
Mass (Da):83,583
Last modified:July 27, 2011 - v2
Checksum:i4D93D9839AD57159
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A4I9A2A4I9_MOUSE
Amine oxidase
Aoc2
730Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53S → N in AAK58865 (PubMed:14585497).Curated1
Sequence conflicti117V → A in AAK58865 (PubMed:14585497).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF350445 mRNA Translation: AAK58864.2
AF350446 Genomic DNA Translation: AAK58865.1
AL590969 Genomic DNA Translation: CAM19554.1
BC150843 mRNA Translation: AAI50844.1
BC150848 mRNA Translation: AAI50849.1
CCDSiCCDS25464.1
RefSeqiNP_849263.1, NM_178932.1
UniGeneiMm.302277

Genome annotation databases

EnsembliENSMUST00000041095; ENSMUSP00000040255; ENSMUSG00000078651
GeneIDi237940
KEGGimmu:237940
UCSCiuc007loo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF350445 mRNA Translation: AAK58864.2
AF350446 Genomic DNA Translation: AAK58865.1
AL590969 Genomic DNA Translation: CAM19554.1
BC150843 mRNA Translation: AAI50844.1
BC150848 mRNA Translation: AAI50849.1
CCDSiCCDS25464.1
RefSeqiNP_849263.1, NM_178932.1
UniGeneiMm.302277

3D structure databases

ProteinModelPortaliQ812C9
SMRiQ812C9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040255

PTM databases

iPTMnetiQ812C9
PhosphoSitePlusiQ812C9

Proteomic databases

MaxQBiQ812C9
PaxDbiQ812C9
PRIDEiQ812C9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041095; ENSMUSP00000040255; ENSMUSG00000078651
GeneIDi237940
KEGGimmu:237940
UCSCiuc007loo.1 mouse

Organism-specific databases

CTDi314
MGIiMGI:2668431 Aoc2

Phylogenomic databases

eggNOGiKOG1186 Eukaryota
COG3733 LUCA
GeneTreeiENSGT00510000046461
HOGENOMiHOG000233919
HOVERGENiHBG004164
InParanoidiQ812C9
KOiK00276
OMAiNANWARY
OrthoDBiEOG091G02WY
TreeFamiTF314750

Enzyme and pathway databases

ReactomeiR-MMU-211945 Phase I - Functionalization of compounds

Miscellaneous databases

PROiPR:Q812C9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000078651 Expressed in 21 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ812C9 baseline and differential

Family and domain databases

Gene3Di2.70.98.20, 1 hit
InterProiView protein in InterPro
IPR032952 AOC2
IPR000269 Cu_amine_oxidase
IPR015798 Cu_amine_oxidase_C
IPR036460 Cu_amine_oxidase_C_sf
IPR016182 Cu_amine_oxidase_N-reg
IPR015800 Cu_amine_oxidase_N2
IPR015802 Cu_amine_oxidase_N3
PANTHERiPTHR10638 PTHR10638, 1 hit
PTHR10638:SF4 PTHR10638:SF4, 1 hit
PfamiView protein in Pfam
PF01179 Cu_amine_oxid, 1 hit
PF02727 Cu_amine_oxidN2, 1 hit
PF02728 Cu_amine_oxidN3, 1 hit
PRINTSiPR00766 CUDAOXIDASE
SUPFAMiSSF49998 SSF49998, 1 hit
SSF54416 SSF54416, 2 hits
PROSITEiView protein in PROSITE
PS01164 COPPER_AMINE_OXID_1, 1 hit
PS01165 COPPER_AMINE_OXID_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAOC2_MOUSE
AccessioniPrimary (citable) accession number: Q812C9
Secondary accession number(s): A2A4J0, Q80WP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again