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Protein

Cytochrome P450 26B1

Gene

Cyp26b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.4 Publications
Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi441Iron (heme axial ligand)Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211916 Vitamins
R-MMU-5365859 RA biosynthesis pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 26B1 (EC:1.14.13.-By similarity)
Alternative name(s):
Cytochrome P450 retinoic acid-inactivating 2
Short name:
Cytochrome P450RAI-2
Gene namesi
Name:Cyp26b1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2176159 Cyp26b1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Disruption phenotypei

Germ cells enter meiosis precociously in embryonic testes, due to strong-up-regulation of Stra8.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004169051 – 512Cytochrome P450 26B1Add BLAST512

Proteomic databases

MaxQBiQ811W2
PaxDbiQ811W2
PRIDEiQ811W2

PTM databases

iPTMnetiQ811W2
PhosphoSitePlusiQ811W2

Expressioni

Developmental stagei

In the embryonic male gonad, expressed in somatic cells as early as E11.5 and persist throughout development. Expression is detected in peritubular myoepithelial cells in the postnatal testis, while expression is absent in developing and adult ovaries.2 Publications

Gene expression databases

BgeeiENSMUSG00000063415 Expressed in 247 organ(s), highest expression level in manus
ExpressionAtlasiQ811W2 baseline and differential
GenevisibleiQ811W2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076886

Structurei

3D structure databases

ProteinModelPortaliQ811W2
SMRiQ811W2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00800000124060
HOGENOMiHOG000220829
HOVERGENiHBG051099
InParanoidiQ811W2
KOiK12664
OMAiKEGRFHY
OrthoDBiEOG091G0K6Z
PhylomeDBiQ811W2
TreeFamiTF105093

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002403 Cyt_P450_E_grp-IV
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00465 EP450IV
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q811W2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLFEGLELVS ALATLAACLV SVTLLLAVSQ QLWQLRWAAT RDKSCKLPIP
60 70 80 90 100
KGSMGFPLIG ETGHWLLQGS GFQSSRREKY GNVFKTHLLG RPLIRVTGAE
110 120 130 140 150
NVRKILLGEH QLVSTEWPRS ARVLLGPNTV ANSIGDIHRN KRKVFSKIFS
160 170 180 190 200
HEALESYLPK IQLVIQDTLR AWSSQPEAIN VYQEAQRLTF RMAVRVLLGF
210 220 230 240 250
SIPEEDLGHL FEVYQQFVEN VFSLPVDLPF SGYRRGIQAR QILQKGLEKA
260 270 280 290 300
IREKLQCTQG KDYSDALDIL IESSKEHGKE MTMQELKDGT LELIFAAYAT
310 320 330 340 350
TASASTSLIM QLLKHPAVLE KLREELRAQG LLHGGGCPCE GTLRLDTLSS
360 370 380 390 400
LRYLDCVIKE VMRLFTPVSG GYRTVLQTFE LDGFQIPKGW SVMYSIRDTH
410 420 430 440 450
DTAPVFKDVN VFDPDRFSQA RSEDKDGRFH YLPFGGGVRT CLGKHLAKLF
460 470 480 490 500
LKVLAVELAS TSRFELATRT FPRITLVPVL HPVDGLSVKF FGLDSNQNEI
510
LPETEAMLSA TV
Length:512
Mass (Da):57,375
Last modified:June 1, 2003 - v1
Checksum:iAAA063DE5718824E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SUV4A0A0N4SUV4_MOUSE
Cytochrome P450 26B1
Cyp26b1
321Annotation score:
A0A0N4SV88A0A0N4SV88_MOUSE
Cytochrome P450 26B1
Cyp26b1
437Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67 – 68LQ → TR in BAE38630 (PubMed:16141072).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY134662 mRNA Translation: AAN08613.1
AK137124 mRNA Translation: BAE23242.1
AK166211 mRNA Translation: BAE38630.1
AC153606 Genomic DNA No translation available.
CH466523 Genomic DNA Translation: EDK99117.1
BC059246 mRNA Translation: AAH59246.1
CCDSiCCDS20289.1
RefSeqiNP_001171184.1, NM_001177713.1
NP_780684.1, NM_175475.3
UniGeneiMm.255246

Genome annotation databases

EnsembliENSMUST00000077705; ENSMUSP00000076886; ENSMUSG00000063415
ENSMUST00000168003; ENSMUSP00000128391; ENSMUSG00000063415
ENSMUST00000204146; ENSMUSP00000145092; ENSMUSG00000063415
GeneIDi232174
KEGGimmu:232174
UCSCiuc009coy.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY134662 mRNA Translation: AAN08613.1
AK137124 mRNA Translation: BAE23242.1
AK166211 mRNA Translation: BAE38630.1
AC153606 Genomic DNA No translation available.
CH466523 Genomic DNA Translation: EDK99117.1
BC059246 mRNA Translation: AAH59246.1
CCDSiCCDS20289.1
RefSeqiNP_001171184.1, NM_001177713.1
NP_780684.1, NM_175475.3
UniGeneiMm.255246

3D structure databases

ProteinModelPortaliQ811W2
SMRiQ811W2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076886

PTM databases

iPTMnetiQ811W2
PhosphoSitePlusiQ811W2

Proteomic databases

MaxQBiQ811W2
PaxDbiQ811W2
PRIDEiQ811W2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077705; ENSMUSP00000076886; ENSMUSG00000063415
ENSMUST00000168003; ENSMUSP00000128391; ENSMUSG00000063415
ENSMUST00000204146; ENSMUSP00000145092; ENSMUSG00000063415
GeneIDi232174
KEGGimmu:232174
UCSCiuc009coy.2 mouse

Organism-specific databases

CTDi56603
MGIiMGI:2176159 Cyp26b1

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00800000124060
HOGENOMiHOG000220829
HOVERGENiHBG051099
InParanoidiQ811W2
KOiK12664
OMAiKEGRFHY
OrthoDBiEOG091G0K6Z
PhylomeDBiQ811W2
TreeFamiTF105093

Enzyme and pathway databases

ReactomeiR-MMU-211916 Vitamins
R-MMU-5365859 RA biosynthesis pathway

Miscellaneous databases

ChiTaRSiCyp26b1 mouse
PROiPR:Q811W2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063415 Expressed in 247 organ(s), highest expression level in manus
ExpressionAtlasiQ811W2 baseline and differential
GenevisibleiQ811W2 MM

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002403 Cyt_P450_E_grp-IV
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00465 EP450IV
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP26B_MOUSE
AccessioniPrimary (citable) accession number: Q811W2
Secondary accession number(s): Q3TM12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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