Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ELKS/Rab6-interacting/CAST family member 1

Gene

Erc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex (By similarity). May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.By similarity

GO - Molecular functioni

  • PDZ domain binding Source: RGD
  • Rab GTPase binding Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
ELKS/Rab6-interacting/CAST family member 1
Short name:
ERC-1
Alternative name(s):
CAZ-associated structural protein 2
Short name:
CAST2
Rab6-interacting protein 2
Gene namesi
Name:Erc1
Synonyms:Cast2, Elks, Rab6ip2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628733 Erc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi943E → K or A: No effect on RIMS1 and RIMS2 binding. 1
Mutagenesisi944E → K or A: No effect on RIMS1 and RIMS2 binding. 1
Mutagenesisi945G → D or A: Abolishes RIMS1 and RIMS2 binding. 1
Mutagenesisi946I → D or A: Abolishes RIMS1 and RIMS2 binding. 1
Mutagenesisi947W → D or A: Abolishes RIMS1 and RIMS2 binding. 1
Mutagenesisi948A → D: Abolishes RIMS1 and RIMS2 binding. 1
Mutagenesisi948A → L: Weakens RIMS1 and abolishes RIMS2 binding. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000971781 – 948ELKS/Rab6-interacting/CAST family member 1Add BLAST948

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10N6-acetyllysineBy similarity1
Modified residuei17PhosphoserineBy similarity1
Modified residuei21PhosphoserineBy similarity1
Modified residuei37PhosphoserineBy similarity1
Modified residuei38PhosphothreonineBy similarity1
Modified residuei55PhosphoserineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei94PhosphoserineBy similarity1
Modified residuei796PhosphoserineBy similarity1
Modified residuei937PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ811U3
PRIDEiQ811U3

PTM databases

iPTMnetiQ811U3
PhosphoSitePlusiQ811U3

Expressioni

Tissue specificityi

Isoform 1 is specifically expressed in brain. A further probable isoform is widely expressed outside of brain It is referred to as ERC1a by PubMed:12391317 and characterized by a C-terminus identical to that of isoforms 1 in human and mouse.1 Publication

Interactioni

Subunit structurei

Interacts with the GTB-bound forms of RAB6A isoform 1 and isoform 2 and with RAB6B. The interaction was strongest with RAB6B, followed by RAB6A isoform 2 and weakest with RAB6A isoform 1 (By similarity). Part of a complex with CHUK, IKBKB and IKBKG. Interacts with CHUK, IKBKB and IKBKG. The interaction with IKBKG is independent of CHUK and IKBKB. Interacts with NFKBIA (By similarity). Isoform 1 interacts through its C-terminus with the PDZ domains of RIMS1 and RIMS2. Interacts with ERC2/CAST1.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Rims1Q9JIR48EBI-3507502,EBI-3507436

GO - Molecular functioni

Protein-protein interaction databases

BioGridi251829, 1 interactor
ELMiQ811U3
IntActiQ811U3, 3 interactors
MINTiQ811U3
STRINGi10116.ENSRNOP00000012397

Structurei

3D structure databases

ProteinModelPortaliQ811U3
SMRiQ811U3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ811U3

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili144 – 920Sequence analysisAdd BLAST777

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4809 Eukaryota
ENOG410Y4GU LUCA
HOGENOMiHOG000236353
HOVERGENiHBG051496
InParanoidiQ811U3
KOiK16072

Family and domain databases

InterProiView protein in InterPro
IPR019323 ELKS/CAST
PfamiView protein in Pfam
PF10174 Cast, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q811U3-1) [UniParc]FASTAAdd to basket
Also known as: CAST2a, ERC1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYGSARSVGK VEPSSQSPGR SPRLPRSPRL GHRRTNSTGG SSGNSVGGGS
60 70 80 90 100
GKTLSMENIQ SLNAAYATSG PMYLSDHENV GAETPKSTMT LGRSGGRLPY
110 120 130 140 150
GVRMTAMGSS PNIASSGVAS DTIAFGEHHL PPVSMASTVP HSLRQARDNT
160 170 180 190 200
IMDLQTQLKE VLRENDLLRK DVEVKESKLS SSMNSIKTFW SPELKKERAL
210 220 230 240 250
RKDEASKITI WKEQYRVVQE ENQHMQMTIQ ALQDELRIQR DLNQLFQQDS
260 270 280 290 300
SSRTGEPCVA ELTEENFQRL HAEHERQAKE LFLLRKTLEE MELRIETQKQ
310 320 330 340 350
TLNARDESIK KLLEMLQSKG LSAKATEEDH ERTRRLAEAE MHVHHLESLL
360 370 380 390 400
EQKEKENNML REEMHRRFEN APDSAKTKAL QTVIEMKDSK ISSMERGLRD
410 420 430 440 450
LEEEIQMLKS NGALSTEERE EEMKQMEVYR SHSKFMKNKI GQVKQELSRK
460 470 480 490 500
DTELLALQTK LETLTNQFSD SKQHIEVLKE SLTAKEQRAA ILQTEVDALR
510 520 530 540 550
LRLEEKETML NKKTKQIQDM AEEKGTQAGE IHDLKDMLDV KERKVNVLQK
560 570 580 590 600
KIENLQEQLR DKEKQMSSLK ERVKSLQADT TNTDTALTTL EEALADKERT
610 620 630 640 650
IERLKEQRDR DEREKQEEID TYKKDLKDLK EKVSLLQGDL SEKEASLLDL
660 670 680 690 700
KEHASSLASS GLKKDSRLKT LEIALEQKKE ECLKMESQLK KAHEATLEAR
710 720 730 740 750
ASPEMSDRIQ QLEREIARYK DESSKAQTEV DRLLEILKEV ENEKNDKDKK
760 770 780 790 800
IAELESLTSR QVKDQNKKVA NLKHKEQVEK KKSAQMLEEA RRREDSLSDS
810 820 830 840 850
SQQLQVEELL MAMEKVKQEL ESMKAKLSST QQSLAEKETH LTNLRAERRK
860 870 880 890 900
HLEEVLEMKQ EALLAAISEK DANIALLELS SSKKKTQEEV AALKREKDRL
910 920 930 940
VQQLKQQTQN RMKLMADNYE DDHFRSSRSN QTNHKPSPDQ DEEEGIWA
Length:948
Mass (Da):108,818
Last modified:June 1, 2003 - v1
Checksum:i7CC15D7B1939561C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JYT1A0A0G2JYT1_RAT
ELKS/Rab6-interacting/CAST family m...
Erc1
1,120Annotation score:
F1LPE9F1LPE9_RAT
ELKS/Rab6-interacting/CAST family m...
Erc1
948Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti771N → S in AAN39293 (PubMed:12391317).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY174115 mRNA Translation: AAO25554.1
AF541926 mRNA Translation: AAN39293.1
RefSeqiNP_740769.2, NM_170788.2 [Q811U3-1]
UniGeneiRn.207836

Genome annotation databases

GeneIDi266806
KEGGirno:266806
UCSCiRGD:628733 rat [Q811U3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY174115 mRNA Translation: AAO25554.1
AF541926 mRNA Translation: AAN39293.1
RefSeqiNP_740769.2, NM_170788.2 [Q811U3-1]
UniGeneiRn.207836

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZUBNMR-B939-948[»]
ProteinModelPortaliQ811U3
SMRiQ811U3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251829, 1 interactor
ELMiQ811U3
IntActiQ811U3, 3 interactors
MINTiQ811U3
STRINGi10116.ENSRNOP00000012397

PTM databases

iPTMnetiQ811U3
PhosphoSitePlusiQ811U3

Proteomic databases

PaxDbiQ811U3
PRIDEiQ811U3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi266806
KEGGirno:266806
UCSCiRGD:628733 rat [Q811U3-1]

Organism-specific databases

CTDi23085
RGDi628733 Erc1

Phylogenomic databases

eggNOGiKOG4809 Eukaryota
ENOG410Y4GU LUCA
HOGENOMiHOG000236353
HOVERGENiHBG051496
InParanoidiQ811U3
KOiK16072

Miscellaneous databases

EvolutionaryTraceiQ811U3
PROiPR:Q811U3

Family and domain databases

InterProiView protein in InterPro
IPR019323 ELKS/CAST
PfamiView protein in Pfam
PF10174 Cast, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRB6I2_RAT
AccessioniPrimary (citable) accession number: Q811U3
Secondary accession number(s): Q8CIY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again