UniProtKB - Q811S7 (UBIP1_MOUSE)
Protein
Upstream-binding protein 1
Gene
Ubp1
Organism
Mus musculus (Mouse)
Status
Functioni
Functions as a transcriptional activator in a promoter context-dependent manner. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2. Functions as a trans-acting factor that regulates the domestic strain CYP2D9 gene through specific association with the regulatory element SDI-A1. Binding to SDI-A1 depends on the type of nucleotide at position 299; binding is abolished by a nucleotide substitution at this position. Modulates the placental expression of CYP11A1 (By similarity).By similarity2 Publications
Miscellaneous
Present in both domestic and wild mouse strains. Recognizes the genetic difference at position 299 in the SDI-A1 element.
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- angiogenesis Source: MGI
- negative regulation of viral transcription Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Upstream-binding protein 1Alternative name(s): Nuclear factor 2d9 Short name: NF2d9 |
Gene namesi | Name:Ubp1 Synonyms:Cp2b, Nf2d9 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:104889, Ubp1 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000229027 | 1 – 540 | Upstream-binding protein 1Add BLAST | 540 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 22 | PhosphoserineBy similarity | 1 | |
Modified residuei | 390 | PhosphoserineCombined sources | 1 | |
Modified residuei | 393 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q811S7 |
PaxDbi | Q811S7 |
PeptideAtlasi | Q811S7 |
PRIDEi | Q811S7 |
PTM databases
iPTMneti | Q811S7 |
PhosphoSitePlusi | Q811S7 |
Expressioni
Tissue specificityi
Ubiquitous. Highly expressed in erythroid cells.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000009741, Expressed in embryo and 303 other tissues |
Genevisiblei | Q811S7, MM |
Interactioni
Subunit structurei
Interacts with TFCP2 and PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 204421, 11 interactors |
IntActi | Q811S7, 2 interactors |
STRINGi | 10090.ENSMUSP00000081946 |
Miscellaneous databases
RNActi | Q811S7, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 40 | Transcriptional activationAdd BLAST | 40 | |
Regioni | 274 – 309 | Erythroid-specific transcriptional activationAdd BLAST | 36 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4091, Eukaryota |
GeneTreei | ENSGT00940000156148 |
HOGENOMi | CLU_015127_2_0_1 |
InParanoidi | Q811S7 |
OMAi | CFLVTTI |
OrthoDBi | 386296at2759 |
PhylomeDBi | Q811S7 |
TreeFami | TF314132 |
Family and domain databases
CDDi | cd09588, SAM_LBP1, 1 hit |
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR007604, CP2 IPR013761, SAM/pointed_sf IPR041418, SAM_3 IPR040167, TF_CP2-like IPR037600, Ubp1_SAM |
PANTHERi | PTHR11037, PTHR11037, 1 hit |
Pfami | View protein in Pfam PF04516, CP2, 1 hit PF18016, SAM_3, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q811S7-1) [UniParc]FASTAAdd to basket
Also known as: CP2b
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAWVLSMDEV IESGLVHDFD SSLSGIGQEL GAGAYSMSDV LALPIFKQED
60 70 80 90 100
SSLSLEDEAK HPPFQYVMCA ATSPAVKLHD ETLTYLNQGQ SYEIRMLDNR
110 120 130 140 150
KMGDMPELSG KLVKSIIRVV FHDRRLQYTE HQQLEGWKWN RPGDRLLDLD
160 170 180 190 200
IPMSVGIIDT RTNPSQLNAV EFLWDPAKRT SAFIQVHCIS TEFTPRKHGG
210 220 230 240 250
EKGVPFRIQV DTFKQNENGE YTDHLHSASC QIKVFKPKGA DRKQKNDREK
260 270 280 290 300
MEKRTAHEKE KYQPSYDTTI LTEMRLEPII EDAVEHEQKK SSKRTLPADY
310 320 330 340 350
GDSLAKRGSC SPWPDTPTAY VNNSPSPAPT FTSSQPSTCS VPDSNSSSPN
360 370 380 390 400
HQGDGAAQAS GEQIQPSATT QETQQWLLKN RFSSYTRLFS NFSGADLLKL
410 420 430 440 450
TKEDLVQICG AADGIRLYNS LKSRSVRPRL TIYVCQEQPS STALQGQPQA
460 470 480 490 500
AGSGGESGGG TPSVYHAIYL EEMVASEVAR KLASVFNIPF HQINQVYRQG
510 520 530 540
PTGIHILVSD QMVQNFQDET CFLFSTVKAE NNDGIHIILK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 287 | E → K in BAE24526 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017731 | 274 – 309 | Missing in isoform 2. 3 PublicationsAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20086 mRNA Translation: AAC52244.1 AY182062 mRNA Translation: AAO24130.1 BC139828 mRNA Translation: AAI39829.1 AK079815 mRNA Translation: BAC37754.1 AK143282 mRNA Translation: BAE25332.1 AK140942 mRNA Translation: BAE24526.1 |
CCDSi | CCDS40788.1 [Q811S7-1] CCDS40789.1 [Q811S7-2] |
PIRi | I49257 |
RefSeqi | NP_001076788.1, NM_001083319.1 [Q811S7-1] NP_038727.1, NM_013699.2 [Q811S7-2] XP_006512114.2, XM_006512051.3 XP_006512117.2, XM_006512054.3 |
Genome annotation databases
Ensembli | ENSMUST00000009885; ENSMUSP00000009885; ENSMUSG00000009741 [Q811S7-2] ENSMUST00000084885; ENSMUSP00000081946; ENSMUSG00000009741 [Q811S7-1] ENSMUST00000116492; ENSMUSP00000112192; ENSMUSG00000009741 [Q811S7-2] ENSMUST00000214095; ENSMUSP00000149908; ENSMUSG00000009741 [Q811S7-2] ENSMUST00000216558; ENSMUSP00000150023; ENSMUSG00000009741 [Q811S7-1] |
GeneIDi | 22221 |
KEGGi | mmu:22221 |
UCSCi | uc009rwx.1, mouse [Q811S7-1] uc009rwy.1, mouse [Q811S7-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U20086 mRNA Translation: AAC52244.1 AY182062 mRNA Translation: AAO24130.1 BC139828 mRNA Translation: AAI39829.1 AK079815 mRNA Translation: BAC37754.1 AK143282 mRNA Translation: BAE25332.1 AK140942 mRNA Translation: BAE24526.1 |
CCDSi | CCDS40788.1 [Q811S7-1] CCDS40789.1 [Q811S7-2] |
PIRi | I49257 |
RefSeqi | NP_001076788.1, NM_001083319.1 [Q811S7-1] NP_038727.1, NM_013699.2 [Q811S7-2] XP_006512114.2, XM_006512051.3 XP_006512117.2, XM_006512054.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 204421, 11 interactors |
IntActi | Q811S7, 2 interactors |
STRINGi | 10090.ENSMUSP00000081946 |
PTM databases
iPTMneti | Q811S7 |
PhosphoSitePlusi | Q811S7 |
Proteomic databases
EPDi | Q811S7 |
PaxDbi | Q811S7 |
PeptideAtlasi | Q811S7 |
PRIDEi | Q811S7 |
Protocols and materials databases
Antibodypediai | 11705, 311 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000009885; ENSMUSP00000009885; ENSMUSG00000009741 [Q811S7-2] ENSMUST00000084885; ENSMUSP00000081946; ENSMUSG00000009741 [Q811S7-1] ENSMUST00000116492; ENSMUSP00000112192; ENSMUSG00000009741 [Q811S7-2] ENSMUST00000214095; ENSMUSP00000149908; ENSMUSG00000009741 [Q811S7-2] ENSMUST00000216558; ENSMUSP00000150023; ENSMUSG00000009741 [Q811S7-1] |
GeneIDi | 22221 |
KEGGi | mmu:22221 |
UCSCi | uc009rwx.1, mouse [Q811S7-1] uc009rwy.1, mouse [Q811S7-2] |
Organism-specific databases
CTDi | 7342 |
MGIi | MGI:104889, Ubp1 |
Phylogenomic databases
eggNOGi | KOG4091, Eukaryota |
GeneTreei | ENSGT00940000156148 |
HOGENOMi | CLU_015127_2_0_1 |
InParanoidi | Q811S7 |
OMAi | CFLVTTI |
OrthoDBi | 386296at2759 |
PhylomeDBi | Q811S7 |
TreeFami | TF314132 |
Miscellaneous databases
BioGRID-ORCSi | 22221, 11 hits in 20 CRISPR screens |
ChiTaRSi | Ubp1, mouse |
PROi | PR:Q811S7 |
RNActi | Q811S7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000009741, Expressed in embryo and 303 other tissues |
Genevisiblei | Q811S7, MM |
Family and domain databases
CDDi | cd09588, SAM_LBP1, 1 hit |
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR007604, CP2 IPR013761, SAM/pointed_sf IPR041418, SAM_3 IPR040167, TF_CP2-like IPR037600, Ubp1_SAM |
PANTHERi | PTHR11037, PTHR11037, 1 hit |
Pfami | View protein in Pfam PF04516, CP2, 1 hit PF18016, SAM_3, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBIP1_MOUSE | |
Accessioni | Q811S7Primary (citable) accession number: Q811S7 Secondary accession number(s): A4QPG4 Q8C514 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2006 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families