Ubp1

Functionⁱ

Functions as a transcriptional activator in a promoter context-dependent manner. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2. Functions as a trans-acting factor that regulates the domestic strain CYP2D9 gene through specific association with the regulatory element SDI-A1. Binding to SDI-A1 depends on the type of nucleotide at position 299; binding is abolished by a nucleotide substitution at this position. Modulates the placental expression of CYP11A1 (By similarity).By similarity2 Publications

Miscellaneous

Present in both domestic and wild mouse strains. Recognizes the genetic difference at position 299 in the SDI-A1 element.

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 15282311
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Upstream-binding protein 1 Alternative name(s): Nuclear factor 2d9 Short name: NF2d9
Gene namesⁱ	Name:Ubp1 Synonyms:Cp2b, Nf2d9
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:104889 Ubp1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000229027	1 – 540	Upstream-binding protein 1Add BLAST		540

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	22	PhosphoserineBy similarity	1
Modified residueⁱ	390	PhosphoserineCombined sources	1
Modified residueⁱ	393	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q811S7
PaxDbⁱ	Q811S7
PeptideAtlas More...PeptideAtlasⁱ	Q811S7
PRIDEⁱ	Q811S7

PTM databases

iPTMnetⁱ	Q811S7
PhosphoSitePlusⁱ	Q811S7

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Highly expressed in erythroid cells.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000009741 Expressed in 286 organ(s), highest expression level in embryo
CleanExⁱ	MM_UBP1
Genevisibleⁱ	Q811S7 MM

Interactionⁱ

Subunit structureⁱ

Interacts with TFCP2 and PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1.2 Publications

Protein-protein interaction databases

BioGridⁱ	204421, 9 interactors
IntActⁱ	Q811S7, 2 interactors
STRINGⁱ	10090.ENSMUSP00000081946

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q811S7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 40	Transcriptional activationAdd BLAST		40
Regionⁱ	274 – 309	Erythroid-specific transcriptional activationAdd BLAST		36

Sequence similaritiesⁱ

Belongs to the grh/CP2 family. CP2 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG4091 Eukaryota ENOG410XNZ6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119235
HOGENOMⁱ	HOG000230625
HOVERGENⁱ	HBG053805
InParanoidⁱ	Q811S7
KEGG Orthology (KO) More...KOⁱ	K09275
OMAⁱ	HPSATIQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0YV2
PhylomeDBⁱ	Q811S7
TreeFamⁱ	TF314132

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd09588 SAM_LBP1, 1 hit
InterProⁱ	View protein in InterPro IPR007604 CP2 IPR013761 SAM/pointed_sf IPR037600 Ubp1_SAM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04516 CP2, 1 hit
SUPFAMⁱ	SSF47769 SSF47769, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q811S7-1) [UniParc]FASTA Add to basket

Also known as: CP2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWVLSMDEV IESGLVHDFD SSLSGIGQEL GAGAYSMSDV LALPIFKQED 
        60         70         80         90        100
SSLSLEDEAK HPPFQYVMCA ATSPAVKLHD ETLTYLNQGQ SYEIRMLDNR 
       110        120        130        140        150
KMGDMPELSG KLVKSIIRVV FHDRRLQYTE HQQLEGWKWN RPGDRLLDLD 
       160        170        180        190        200
IPMSVGIIDT RTNPSQLNAV EFLWDPAKRT SAFIQVHCIS TEFTPRKHGG 
       210        220        230        240        250
EKGVPFRIQV DTFKQNENGE YTDHLHSASC QIKVFKPKGA DRKQKNDREK 
       260        270        280        290        300
MEKRTAHEKE KYQPSYDTTI LTEMRLEPII EDAVEHEQKK SSKRTLPADY 
       310        320        330        340        350
GDSLAKRGSC SPWPDTPTAY VNNSPSPAPT FTSSQPSTCS VPDSNSSSPN 
       360        370        380        390        400
HQGDGAAQAS GEQIQPSATT QETQQWLLKN RFSSYTRLFS NFSGADLLKL 
       410        420        430        440        450
TKEDLVQICG AADGIRLYNS LKSRSVRPRL TIYVCQEQPS STALQGQPQA 
       460        470        480        490        500
AGSGGESGGG TPSVYHAIYL EEMVASEVAR KLASVFNIPF HQINQVYRQG 
       510        520        530        540
PTGIHILVSD QMVQNFQDET CFLFSTVKAE NNDGIHIILK

Length:540

Mass (Da):60,212

Last modified:June 1, 2003 - v1

Checksum:ⁱA0D66024E36CCEB9

GO

Isoform 2 (identifier: Q811S7-2) [UniParc]FASTA Add to basket

Also known as: CP2a

The sequence of this isoform differs from the canonical sequence as follows:
274-309: Missing.

« Hide

        10         20         30         40         50
MAWVLSMDEV IESGLVHDFD SSLSGIGQEL GAGAYSMSDV LALPIFKQED 
        60         70         80         90        100
SSLSLEDEAK HPPFQYVMCA ATSPAVKLHD ETLTYLNQGQ SYEIRMLDNR 
       110        120        130        140        150
KMGDMPELSG KLVKSIIRVV FHDRRLQYTE HQQLEGWKWN RPGDRLLDLD 
       160        170        180        190        200
IPMSVGIIDT RTNPSQLNAV EFLWDPAKRT SAFIQVHCIS TEFTPRKHGG 
       210        220        230        240        250
EKGVPFRIQV DTFKQNENGE YTDHLHSASC QIKVFKPKGA DRKQKNDREK 
       260        270        280        290        300
MEKRTAHEKE KYQPSYDTTI LTECSPWPDT PTAYVNNSPS PAPTFTSSQP 
       310        320        330        340        350
STCSVPDSNS SSPNHQGDGA AQASGEQIQP SATTQETQQW LLKNRFSSYT 
       360        370        380        390        400
RLFSNFSGAD LLKLTKEDLV QICGAADGIR LYNSLKSRSV RPRLTIYVCQ 
       410        420        430        440        450
EQPSSTALQG QPQAAGSGGE SGGGTPSVYH AIYLEEMVAS EVARKLASVF 
       460        470        480        490        500
NIPFHQINQV YRQGPTGIHI LVSDQMVQNF QDETCFLFST VKAENNDGIH 

IILK

Show »

Length:504

Mass (Da):56,173

Checksum:ⁱE0F79D8580F830D7

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	287	E → K in BAE24526 (PubMed:16141072).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_017731	274 – 309	Missing in isoform 2. 3 PublicationsAdd BLAST		36

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U20086 mRNA Translation: AAC52244.1 AY182062 mRNA Translation: AAO24130.1 BC139828 mRNA Translation: AAI39829.1 AK079815 mRNA Translation: BAC37754.1 AK143282 mRNA Translation: BAE25332.1 AK140942 mRNA Translation: BAE24526.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS40788.1 [Q811S7-1] CCDS40789.1 [Q811S7-2]
PIRⁱ	I49257
NCBI Reference Sequences More...RefSeqⁱ	NP_001076788.1, NM_001083319.1 [Q811S7-1] NP_038727.1, NM_013699.2 [Q811S7-2] XP_006512114.2, XM_006512051.3 [Q811S7-1] XP_006512117.2, XM_006512054.3 [Q811S7-2]
UniGeneⁱ	Mm.28052 Mm.386808

Genome annotation databases

Ensemblⁱ	ENSMUST00000009885; ENSMUSP00000009885; ENSMUSG00000009741 [Q811S7-2] ENSMUST00000084885; ENSMUSP00000081946; ENSMUSG00000009741 [Q811S7-1] ENSMUST00000116492; ENSMUSP00000112192; ENSMUSG00000009741 [Q811S7-2] ENSMUST00000214095; ENSMUSP00000149908; ENSMUSG00000009741 [Q811S7-2] ENSMUST00000216558; ENSMUSP00000150023; ENSMUSG00000009741 [Q811S7-1]
GeneIDⁱ	22221
KEGGⁱ	mmu:22221
UCSC genome browser More...UCSCⁱ	uc009rwx.1 mouse [Q811S7-1] uc009rwy.1 mouse [Q811S7-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q811S7	Upstream-binding protein 1		HUMAN		540	UniRef90_Q9NZI7
Uncharacterized protein		MYOLU		542
Uncharacterized protein		AOTNA		540
Upstream binding protein 1		GORGO		540
UBP1 (Fragment)		western gorilla		149
+113
Q811S7-2	upstream-binding protein 1 isoform X3		TURTR		518	UniRef90_Q811S7-2
Uncharacterized protein		PAPAN		505
upstream-binding protein 1 isoform X2		MESAU		504
Upstream binding protein 1 (LBP-1a), isoform CRA_b		HUMAN		504
upstream-binding protein 1 isoform X4		Florida manatee		504
+92

Protein	Similar proteins		Species	Score	Length	Source
Q811S7	Alpha-globin transcription factor CP2		HUMAN		502	UniRef50_Q12800
Transcription factor CP2		XENTR		507
Transcription factor CP2		XENLA		506
Alpha-globin transcription factor CP2		MOUSE		502
Transcription factor CP2		CHICK		496
+983

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U20086 mRNA Translation: AAC52244.1 AY182062 mRNA Translation: AAO24130.1 BC139828 mRNA Translation: AAI39829.1 AK079815 mRNA Translation: BAC37754.1 AK143282 mRNA Translation: BAE25332.1 AK140942 mRNA Translation: BAE24526.1
CCDSⁱ	CCDS40788.1 [Q811S7-1] CCDS40789.1 [Q811S7-2]
PIRⁱ	I49257
RefSeqⁱ	NP_001076788.1, NM_001083319.1 [Q811S7-1] NP_038727.1, NM_013699.2 [Q811S7-2] XP_006512114.2, XM_006512051.3 [Q811S7-1] XP_006512117.2, XM_006512054.3 [Q811S7-2]
UniGeneⁱ	Mm.28052 Mm.386808

3D structure databases

ProteinModelPortalⁱ	Q811S7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204421, 9 interactors
IntActⁱ	Q811S7, 2 interactors
STRINGⁱ	10090.ENSMUSP00000081946

PTM databases

iPTMnetⁱ	Q811S7
PhosphoSitePlusⁱ	Q811S7

Proteomic databases

EPDⁱ	Q811S7
PaxDbⁱ	Q811S7
PeptideAtlasⁱ	Q811S7
PRIDEⁱ	Q811S7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000009885; ENSMUSP00000009885; ENSMUSG00000009741 [Q811S7-2] ENSMUST00000084885; ENSMUSP00000081946; ENSMUSG00000009741 [Q811S7-1] ENSMUST00000116492; ENSMUSP00000112192; ENSMUSG00000009741 [Q811S7-2] ENSMUST00000214095; ENSMUSP00000149908; ENSMUSG00000009741 [Q811S7-2] ENSMUST00000216558; ENSMUSP00000150023; ENSMUSG00000009741 [Q811S7-1]
GeneIDⁱ	22221
KEGGⁱ	mmu:22221
UCSCⁱ	uc009rwx.1 mouse [Q811S7-1] uc009rwy.1 mouse [Q811S7-2]

Organism-specific databases

CTDⁱ	7342
MGIⁱ	MGI:104889 Ubp1

Phylogenomic databases

eggNOGⁱ	KOG4091 Eukaryota ENOG410XNZ6 LUCA
GeneTreeⁱ	ENSGT00760000119235
HOGENOMⁱ	HOG000230625
HOVERGENⁱ	HBG053805
InParanoidⁱ	Q811S7
KOⁱ	K09275
OMAⁱ	HPSATIQ
OrthoDBⁱ	EOG091G0YV2
PhylomeDBⁱ	Q811S7
TreeFamⁱ	TF314132

Miscellaneous databases

ChiTaRSⁱ	Ubp1 mouse
Protein Ontology More...PROⁱ	PR:Q811S7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000009741 Expressed in 286 organ(s), highest expression level in embryo
CleanExⁱ	MM_UBP1
Genevisibleⁱ	Q811S7 MM

Family and domain databases

CDDⁱ	cd09588 SAM_LBP1, 1 hit
InterProⁱ	View protein in InterPro IPR007604 CP2 IPR013761 SAM/pointed_sf IPR037600 Ubp1_SAM
Pfamⁱ	View protein in Pfam PF04516 CP2, 1 hit
SUPFAMⁱ	SSF47769 SSF47769, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UBIP1_MOUSE
Accessionⁱ	Q811S7Primary (citable) accession number: Q811S7 Secondary accession number(s): A4QPG4 , Q3UPR3, Q3US11, Q60786, Q8C514
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
	Last sequence update:	June 1, 2003
	Last modified:	November 7, 2018
	This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q811S7 (UBIP1_MOUSE)

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Upstream-binding protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ