UniProtKB - Q811Q3 (Q811Q3_MOUSE)
Protein
Submitted name:
A disintegrin and metallopeptidase domain 30
Gene
Adam30
Organism
Mus musculus (Mouse)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- metalloendopeptidase activity Source: InterPro
GO - Biological processi
- integrin-mediated signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | IntegrinImported |
Enzyme and pathway databases
Reactomei | R-MMU-2534343, Interaction With Cumulus Cells And The Zona Pellucida |
Protein family/group databases
MEROPSi | M12.240 |
Names & Taxonomyi
Protein namesi | Submitted name: A disintegrin and metallopeptidase domain 30ImportedSubmitted name: ADAM30Imported |
Gene namesi | Name:Adam30Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1918328, Adam30 |
Subcellular locationi
Plasma Membrane
- external side of plasma membrane Source: MGI
- plasma membrane Source: GO_Central
- sperm head plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 686 – 708 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_5015098942 | 26 – 732 | Sequence analysisAdd BLAST | 707 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 456 ↔ 476 | PROSITE-ProRule annotation | ||
Disulfide bondi | 651 ↔ 660 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000043468, Expressed in spermatid and 15 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 202 – 393 | Peptidase M12BInterPro annotationAdd BLAST | 192 | |
Domaini | 398 – 484 | DisintegrinInterPro annotationAdd BLAST | 87 | |
Domaini | 628 – 661 | EGF-likeInterPro annotationAdd BLAST | 34 |
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG3607, Eukaryota |
GeneTreei | ENSGT00940000162954 |
HOGENOMi | CLU_012714_4_0_1 |
OMAi | ICGRLQC |
OrthoDBi | 162519at2759 |
TreeFami | TF314733 |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR006586, ADAM_Cys-rich IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR000742, EGF-like_dom IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q811Q3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRSVWAFLPQ HRWLFLTMLF HEAVGEEDLL FDPDWGFDSY EITIPKVISF
60 70 80 90 100
KKGAQGVDSS LSYLLQIEGK ARVVHLRPKK LLLPRHLPVF SFTQEGSLIE
110 120 130 140 150
DYPHIPDQCN YVGSVEGSQE SESTLSTCMG GLRGVLNIDS RYYQIEPLRA
160 170 180 190 200
SSSFEHVVYL VTEDNFNNET CGVVDEETGG QTAEEEEMAR ISSFHQSYKH
210 220 230 240 250
QRYLELVMVF DLDRFVFARG NMSRMVDDAI LLASIADTYF QDVSLKIQLK
260 270 280 290 300
ALEVWTYYNR IRLYYPSLSE VLGQFVHYKR NSMHHRLPAD WFHLYIARRY
310 320 330 340 350
IDANAWSWGR ACEEFHAGSA SSFLNVNILG PATWTAHELG HCVGMIHDEE
360 370 380 390 400
FCQCRGRKSC IMGTGRTGFS NCSYHQYFLH ASYKMSYCLS DFPKLHIVER
410 420 430 440 450
CGNKIVENKE ECDCGSKEDC KKDLCCGPDC KWKEGVNCSS GLCCHKCNFL
460 470 480 490 500
PSGYVCRKEV NECDLEEYCD GTSGVCPDDS YKQDGTPCRN GGFCFRKGCR
510 520 530 540 550
SRYLQCQSIF GRKAKEAPHQ CYEAVNMLGD QSGNCGIVNA TRYTRCHRGN
560 570 580 590 600
TICGRLQCIN VKALSKFPDH TIILSTYLRG DNLICWGTSY HGTMIPHGVP
610 620 630 640 650
DIGDISDGTS CGRNRVCLNR TCVDYTNLKF DCLPDKCNSR GVCNNRKNCH
660 670 680 690 700
CSYGWEPPFC VEVGYGGSLD SGPPGPRIEV LSTTSALYML RTILFLVSMI
710 720 730
VVCLGQLIRN LFRNRRRNLQ QKNPAETQGK KR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ9CUC4 | Q9CUC4_MOUSE | A disintegrin and metallopeptidase ... | Adam30 | 278 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC154173 Genomic DNA No translation available. BC113152 mRNA Translation: AAI13153.1 BC113762 mRNA Translation: AAI13763.1 AY190760 mRNA Translation: AAO38664.1 |
RefSeqi | NP_081941.1, NM_027665.2 |
Genome annotation databases
Ensembli | ENSMUST00000050342; ENSMUSP00000060505; ENSMUSG00000043468 |
GeneIDi | 71078 |
KEGGi | mmu:71078 |
UCSCi | uc008qpp.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC154173 Genomic DNA No translation available. BC113152 mRNA Translation: AAI13153.1 BC113762 mRNA Translation: AAI13763.1 AY190760 mRNA Translation: AAO38664.1 |
RefSeqi | NP_081941.1, NM_027665.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000060505 |
Protein family/group databases
MEROPSi | M12.240 |
Protocols and materials databases
Antibodypediai | 20207, 83 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000050342; ENSMUSP00000060505; ENSMUSG00000043468 |
GeneIDi | 71078 |
KEGGi | mmu:71078 |
UCSCi | uc008qpp.1, mouse |
Organism-specific databases
CTDi | 11085 |
MGIi | MGI:1918328, Adam30 |
Phylogenomic databases
eggNOGi | KOG3607, Eukaryota |
GeneTreei | ENSGT00940000162954 |
HOGENOMi | CLU_012714_4_0_1 |
OMAi | ICGRLQC |
OrthoDBi | 162519at2759 |
TreeFami | TF314733 |
Enzyme and pathway databases
Reactomei | R-MMU-2534343, Interaction With Cumulus Cells And The Zona Pellucida |
Miscellaneous databases
BioGRID-ORCSi | 71078, 2 hits in 18 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000043468, Expressed in spermatid and 15 other tissues |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR006586, ADAM_Cys-rich IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR000742, EGF-like_dom IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q811Q3_MOUSE | |
Accessioni | Q811Q3Primary (citable) accession number: Q811Q3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2003 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |