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Protein

Calcium-activated potassium channel subunit beta-2

Gene

Kcnmb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-activated potassium channel subunit beta-2
Alternative name(s):
BK channel subunit beta-2
Short name:
BKbeta2
Calcium-activated potassium channel, subfamily M subunit beta-2
Charybdotoxin receptor subunit beta-2
K(VCA)beta-2
Maxi K channel subunit beta-2
Rbeta3
Slo-beta-2
Gene namesi
Name:Kcnmb2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi631398 Kcnmb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46CytoplasmicSequence analysisAdd BLAST46
Transmembranei47 – 67Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini68 – 194ExtracellularSequence analysisAdd BLAST127
Transmembranei195 – 215Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini216 – 235CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001870531 – 235Calcium-activated potassium channel subunit beta-2Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ811Q0
PRIDEiQ811Q0

Expressioni

Tissue specificityi

Highly expressed in brain and heart. Also expressed in lung.1 Publication

Interactioni

Subunit structurei

Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB2 per KCNMA1 tetramer (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013410

Structurei

3D structure databases

ProteinModelPortaliQ811Q0
SMRiQ811Q0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 45Ball and chainAdd BLAST45

Domaini

The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus (By similarity).By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEU4 Eukaryota
ENOG4111FIG LUCA
HOGENOMiHOG000290180
HOVERGENiHBG052223
InParanoidiQ811Q0
KOiK04938
PhylomeDBiQ811Q0

Family and domain databases

Gene3Di4.10.81.20, 1 hit
InterProiView protein in InterPro
IPR003930 K_chnl_Ca-activ_BK_bsu
IPR037096 KCNMB2_ball/chain_dom_sf
IPR015382 KCNMB2_ball_chain_dom
PANTHERiPTHR10258 PTHR10258, 1 hit
PfamiView protein in Pfam
PF03185 CaKB, 1 hit
PF09303 KcnmB2_inactiv, 1 hit
PRINTSiPR01450 BKCHANNELB

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q811Q0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFIWTSGRTS SSYRHDEKRN IYQKIRDHDL LDKRKTVTAL KAGEDRAILL
60 70 80 90 100
GLAMMVCSIM MYFLLGITLL RSYMQSVWTE EAQRALLNVS ITETFNCSFS
110 120 130 140 150
CGPDCWKLSQ YPCLQVYVNL TSSGEKLLLY HTEETMKINQ KCSYIPKCGN
160 170 180 190 200
NFEESMSLVS VVMENFRRHQ HFPCYSDPEG NQKSVILTKL YSSNVLFHSL
210 220 230
FWPTCMMAGG VAIVAMVKLT QYLSLLCERI QRINR
Length:235
Mass (Da):27,154
Last modified:June 1, 2003 - v1
Checksum:iE111B041867A3F70
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K0A6A0A0G2K0A6_RAT
Calcium-activated potassium channel...
Kcnmb2 rCG_41373
235Annotation score:
G3V7A1G3V7A1_RAT
Calcium-activated potassium channel...
Kcnmb2
174Annotation score:
B5BNW4B5BNW4_RAT
Calcium-activated potassium channel...
Kcnmb2 KCNMB2
36Annotation score:
B5BNW3B5BNW3_RAT
Calcium-activated potassium channel...
Kcnmb2 KCNMB2
31Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84R → C in CAD56888 (PubMed:12454985).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY191836 mRNA Translation: AAO43501.1
AJ517198 mRNA Translation: CAD56888.1
RefSeqiNP_789831.1, NM_176861.1
UniGeneiRn.220612
Rn.92476

Genome annotation databases

GeneIDi294961
KEGGirno:294961
UCSCiRGD:631398 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY191836 mRNA Translation: AAO43501.1
AJ517198 mRNA Translation: CAD56888.1
RefSeqiNP_789831.1, NM_176861.1
UniGeneiRn.220612
Rn.92476

3D structure databases

ProteinModelPortaliQ811Q0
SMRiQ811Q0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013410

Proteomic databases

PaxDbiQ811Q0
PRIDEiQ811Q0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi294961
KEGGirno:294961
UCSCiRGD:631398 rat

Organism-specific databases

CTDi10242
RGDi631398 Kcnmb2

Phylogenomic databases

eggNOGiENOG410IEU4 Eukaryota
ENOG4111FIG LUCA
HOGENOMiHOG000290180
HOVERGENiHBG052223
InParanoidiQ811Q0
KOiK04938
PhylomeDBiQ811Q0

Miscellaneous databases

PROiPR:Q811Q0

Family and domain databases

Gene3Di4.10.81.20, 1 hit
InterProiView protein in InterPro
IPR003930 K_chnl_Ca-activ_BK_bsu
IPR037096 KCNMB2_ball/chain_dom_sf
IPR015382 KCNMB2_ball_chain_dom
PANTHERiPTHR10258 PTHR10258, 1 hit
PfamiView protein in Pfam
PF03185 CaKB, 1 hit
PF09303 KcnmB2_inactiv, 1 hit
PRINTSiPR01450 BKCHANNELB
ProtoNetiSearch...

Entry informationi

Entry nameiKCMB2_RAT
AccessioniPrimary (citable) accession number: Q811Q0
Secondary accession number(s): Q8CF83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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