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Entry version 134 (16 Oct 2019)
Sequence version 2 (22 Jul 2008)
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Protein

Rho GTPase-activating protein 32

Gene

Arhgap32

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity.5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 32
Alternative name(s):
Brain-specific Rho GTPase-activating protein
GAB-associated Cdc42/Rac GTPase-activating protein
GC-GAP
Rho-type GTPase-activating protein 32
Rho/Cdc42/Rac GTPase-activating protein RICS
RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling
p200RhoGAP
p250GAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arhgap32
Synonyms:Grit, Kiaa0712, Rics
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2450166 Arhgap32

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are fertile but display abnormal neurite growth.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi58R → K: Does not affect RhoA or CDC42 activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003452041 – 2089Rho GTPase-activating protein 32Add BLAST2089

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei706PhosphoserineBy similarity1
Modified residuei709PhosphoserineCombined sources1
Modified residuei732PhosphoserineCombined sources1
Modified residuei738PhosphoserineCombined sources1
Modified residuei852PhosphoserineCombined sources1
Modified residuei856PhosphoserineCombined sources1
Modified residuei892PhosphoserineBy similarity1
Modified residuei952PhosphoserineCombined sources1
Modified residuei1206PhosphoserineBy similarity1
Modified residuei1526Asymmetric dimethylarginineCombined sources1
Modified residuei1536Asymmetric dimethylarginineCombined sources1
Modified residuei1588PhosphoserineCombined sources1
Modified residuei2039Omega-N-methylarginineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform 2 is phosphorylated on multiple tyrosine residues by FYN (By similarity). Phosphorylated tyrosine residues undergo dephosphorylation after stimulation of NMDA receptors. Phosphorylated in vitro by CaMK2 in the presence of calmodulin and calcium; which inhibits GAP activity.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q811P8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q811P8

PRoteomics IDEntifications database

More...
PRIDEi
Q811P8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q811P8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q811P8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q811P8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 2 are highly expressed in brain, specially in cortex, corpus striatum, hippocampus and thalamus. Low levels in cerebellum, colon, small intestine, and kidney.6 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 1 is detectable by embryonic day 13, whereas isoform 2 is detected postnatally.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000041444 Expressed in 230 organ(s), highest expression level in cingulate cortex

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q811P8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q811P8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NTRK1 (via cytoplasmic domain); the interaction is independent of the phosphorylation state of NTRK1 (By similarity).

Interacts with SHC3 (via SH2 domain) (By similarity).

Interacts with RASA1 (via SH3 domain); the interaction is necessary for the Ras activation and cell transforming activities of ARHGAP32.

Interacts with GAB1 and GAB2.

Interacts with CRK and CRKL.

Found in a complex with CRKL and BCAR1; upon EGF stimulation BCAR1 may be replaced by EGFR (By similarity).

Interacts with NCK1 (via SH3 domain); NCK1 recruits phosphorylated BCAR1 to the complex.

Isoform 2 interacts with FYN; the interaction appears to be dependent on tyrosine phosphorylation of ARHGAP32 (By similarity).

Interacts with EGFR; the interaction requires EGF stimulation and is increased by SHC3.

Interacts with CDC42; the interaction requires constitutively active CDC42.

Interacts with CTNNB1, DLG4, CDH2 and GRIN2B (By similarity) (PubMed:12531901, PubMed:12857875, PubMed:16716191, PubMed:17272280, PubMed:17663722).

Interacts with GPHN (PubMed:27609886).

By similarity6 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
237045, 12 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q811P8

Protein interaction database and analysis system

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IntActi
Q811P8, 7 interactors

Molecular INTeraction database

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MINTi
Q811P8

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000133898

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q811P8

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini131 – 245PX; atypicalAdd BLAST115
Domaini259 – 321SH3PROSITE-ProRule annotationAdd BLAST63
Domaini372 – 567Rho-GAPPROSITE-ProRule annotationAdd BLAST196

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1395 – 1714Interaction with GAB2By similarityAdd BLAST320
Regioni1688 – 2089Interaction with FYNBy similarityAdd BLAST402

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1033 – 1038Poly-Pro6
Compositional biasi1309 – 1314Poly-Pro6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal PX domain interacts specifically with phosphatidylinositides.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PX domain-containing GAP family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1449 Eukaryota
ENOG410Y1FN LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154313

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000090208

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q811P8

KEGG Orthology (KO)

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KOi
K20647

Identification of Orthologs from Complete Genome Data

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OMAi
YGNGQPE

Database of Orthologous Groups

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OrthoDBi
1300981at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q811P8

TreeFam database of animal gene trees

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TreeFami
TF351451

Family and domain databases

Conserved Domains Database

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CDDi
cd07298 PX_RICS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.555.10, 1 hit
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001683 Phox
IPR042139 PX_ARHGAP32
IPR036871 PX_dom_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

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Pfami
View protein in Pfam
PF00787 PX, 1 hit
PF00620 RhoGAP, 1 hit
PF14604 SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00324 RhoGAP, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q811P8-1) [UniParc]FASTAAdd to basket
Also known as: PX-RICS

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METESETSSL GDDSVFWLDC EGVTQLTDGD EEEREESFRK MKSSIHSEED
60 70 80 90 100
DFVPELHRNV HPRERPDWEE TLSAMARGAD VPEIPGDLTL KSCGSTASTK
110 120 130 140 150
VKHVKKLPFT KGHFPKMAEC AHFHYENVEF GSIQLSLSEE QNEVMKNGCE
160 170 180 190 200
SKELVYLVQI ACQGKSWIVK RSYEDFRVLD KHLHLCIYDR RFSQLTELPR
210 220 230 240 250
SDVLKDSPES VTQMLTAYLS RLSTIAGNKI NCGPALTWME IDNKGNHLLV
260 270 280 290 300
HEESSINTPA VGAAHVIKRY TARAPDELTL EVGDIVSVID MPPKVLSTWW
310 320 330 340 350
RGKHGFQVGL FPGHCVELIN QKVPQSVTNS VPKPVSKKHG KLITFLRTFM
360 370 380 390 400
KSRPTKQKLK QRGILKERVF GCDLGEHLLN SGFEVPQVLQ SCTAFIERYG
410 420 430 440 450
IVDGIYRLSG VASNIQRLRH EFDSEHVPDL TKEPYVQDIH SVGSLCKLYF
460 470 480 490 500
RELPNPLLTY QLYEKFSDAV SAATDEERLI KIHDVIQQLP PPHYRTLEFL
510 520 530 540 550
MRHLSLLADY CSITNMHAKN LAIVWAPNLL RSKQIESACF SGTAAFMEVR
560 570 580 590 600
IQSVVVEFIL NHVDVLFSGK ISAVMQEGAA SLSRPKSLLV SSPSTKLLTL
610 620 630 640 650
EEAQARTQAQ VSSPIVTENK YIEVGEGPAA LQGKFHTVIE FPLERKRPQN
660 670 680 690 700
KMKKSPVGSW RSFFNLGKSS SVSKRKLQRN ESEPSEMKAM ALKGGRAEGT
710 720 730 740 750
LRSAKSEESL TSLHAVDGDS KLFRPRRPRS SSDALSASFN GDVLGNRCNS
760 770 780 790 800
YDNLPHDNES EEEVGLLHIP ALVSPHSAED VDLSPPDIGV ASLDFDPMSF
810 820 830 840 850
QCSPPKAESE CLESGASFLD SLGYTRDKLS PSKKDAEAGG SQSQTPGSTA
860 870 880 890 900
SSEPVSPVQE KLSPFFTLDL SPTDDKSSKP SSFTEKVVYA FSPKIGRKLS
910 920 930 940 950
KSPSMNISEP ISVTLPPRVS EVIGTVSNTV AQNASPTSWD KSVEERDVIN
960 970 980 990 1000
RSPTQLQLGK MKAGEREAQE TCEPEAQPLE QGAAEEVELP GTEERPVLSS
1010 1020 1030 1040 1050
QSKAVPSGQS QTGAVTHDPP QDPVPVSSVS LIPPPPPPKN VARMLALALA
1060 1070 1080 1090 1100
ESAQQASSQT LKRPGASQAG CTSYGDTAVV PSEEKLPSSY SSLTLDKTCF
1110 1120 1130 1140 1150
QTDRPAEQFH PQINGLGNCN QPLPEAAAMG GPTQSNTTDS GEQLHQVDLI
1160 1170 1180 1190 1200
GNSLHRNHIS GDPEKARSTS APLTDSEKSD DHGSFPEDHA GKSSVSTVSF
1210 1220 1230 1240 1250
LEQDQSPLHF SCGDQPLSYL GTSVDKPHHS SELTDKSPMP STLPRDKAHH
1260 1270 1280 1290 1300
PLSGSPEENS STATMAYMMA TPARAEPSNS EASRVLAEQP SAADFVAATL
1310 1320 1330 1340 1350
QRTHRTNRPL PPPPSQRPAE QPPVVGQVQE APSIGLNNSH KVQGTAPAPE
1360 1370 1380 1390 1400
RPPESRAMGD PAPIFLSDGT AAAQCPMGAS APQPGLPEKV RESSRAPPLH
1410 1420 1430 1440 1450
LRAESFPGHS CGFAAPVPPT RTMESKMAAA LHSSAADATS SSNYHSFVPS
1460 1470 1480 1490 1500
SASVDDVMPV PLPVSQPKHA SQKIAYSSFA RPDVTAEPFG PENCLHFNMT
1510 1520 1530 1540 1550
PNCQFRPQSV PPHHNKLEPH QVYGARSEPP ASMGPRYNTY VAPGRNMSGH
1560 1570 1580 1590 1600
HSKPCSRVEY VSSLGSSVRN PCCPEDILPY PTIRRVQSLH APPPSMIRSV
1610 1620 1630 1640 1650
PISRTEVPPD DEPAYCPRPV YQYKPYQSSQ ARSDYHVTQL QPYFENGRVH
1660 1670 1680 1690 1700
YRYSPYSSSS SSYYSPEGAL CDVDAYGTVQ LRPLHRLSSR DFAFYNPRLQ
1710 1720 1730 1740 1750
GKNVYNYAGL PPRPRANATG YFSGNDHNVV TMPPTADGKH TYTSWDLEDM
1760 1770 1780 1790 1800
EKYRMQSIRR ESRARQKVKG PIMSQYDNMT PAVQEDLGGI YVIHLRSKSD
1810 1820 1830 1840 1850
PGKTGLLSVA EGKEGRHPAK AVSPEGDERF YRKHPESEFD RAHHHGGYGS
1860 1870 1880 1890 1900
TQAEKPSLPQ KQSSLRNRKL HDMGCSLPEH RAHQEASHRQ LCESKNGPPY
1910 1920 1930 1940 1950
PQGAGQLDYG SKGMPDTSEP SNYHNSGKYM TSGQGSLTLN HKEVRLPKDL
1960 1970 1980 1990 2000
DRPRARQPPG PEKHSRDCYK EEEHFSQSMV PPPKPERSHS LKLHHTQNLE
2010 2020 2030 2040 2050
RDPSVLYQYQ THSKRQSSMT VVSQYDNLED YHSLPQHQRG GFGGAGMGAY
2060 2070 2080
VPSGFVHPQS RTYATALGQG AFLPTELSLP HPDTQIHAE
Length:2,089
Mass (Da):229,719
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7C4BD904D903F02
GO
Isoform 2 (identifier: Q811P8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-349: Missing.

Show »
Length:1,740
Mass (Da):190,331
Checksum:iAE701A72F0383D69
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R2G6S4R2G6_MOUSE
Rho GTPase-activating protein 32
Arhgap32
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2C0S4R2C0_MOUSE
Rho GTPase-activating protein 32
Arhgap32
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0349371 – 349Missing in isoform 2. 2 PublicationsAdd BLAST349

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY194286 mRNA Translation: AAO43676.1
AC134607 Genomic DNA No translation available.
BC132390 mRNA Translation: AAI32391.1
BC138042 mRNA Translation: AAI38043.1
AK173008 mRNA Translation: BAD32286.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS22951.3 [Q811P8-2]
CCDS57666.1 [Q811P8-1]

NCBI Reference Sequences

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RefSeqi
NP_001182561.1, NM_001195632.1 [Q811P8-1]
NP_796353.3, NM_177379.4 [Q811P8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000168954; ENSMUSP00000128448; ENSMUSG00000041444 [Q811P8-2]
ENSMUST00000174641; ENSMUSP00000133898; ENSMUSG00000041444 [Q811P8-1]
ENSMUST00000182802; ENSMUSP00000138145; ENSMUSG00000041444 [Q811P8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
330914

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:330914

UCSC genome browser

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UCSCi
uc009orv.2 mouse [Q811P8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY194286 mRNA Translation: AAO43676.1
AC134607 Genomic DNA No translation available.
BC132390 mRNA Translation: AAI32391.1
BC138042 mRNA Translation: AAI38043.1
AK173008 mRNA Translation: BAD32286.1
CCDSiCCDS22951.3 [Q811P8-2]
CCDS57666.1 [Q811P8-1]
RefSeqiNP_001182561.1, NM_001195632.1 [Q811P8-1]
NP_796353.3, NM_177379.4 [Q811P8-2]

3D structure databases

SMRiQ811P8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi237045, 12 interactors
CORUMiQ811P8
IntActiQ811P8, 7 interactors
MINTiQ811P8
STRINGi10090.ENSMUSP00000133898

PTM databases

iPTMnetiQ811P8
PhosphoSitePlusiQ811P8
SwissPalmiQ811P8

Proteomic databases

jPOSTiQ811P8
PaxDbiQ811P8
PRIDEiQ811P8

Genome annotation databases

EnsembliENSMUST00000168954; ENSMUSP00000128448; ENSMUSG00000041444 [Q811P8-2]
ENSMUST00000174641; ENSMUSP00000133898; ENSMUSG00000041444 [Q811P8-1]
ENSMUST00000182802; ENSMUSP00000138145; ENSMUSG00000041444 [Q811P8-2]
GeneIDi330914
KEGGimmu:330914
UCSCiuc009orv.2 mouse [Q811P8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9743
MGIiMGI:2450166 Arhgap32

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1449 Eukaryota
ENOG410Y1FN LUCA
GeneTreeiENSGT00940000154313
HOGENOMiHOG000090208
InParanoidiQ811P8
KOiK20647
OMAiYGNGQPE
OrthoDBi1300981at2759
PhylomeDBiQ811P8
TreeFamiTF351451

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Arhgap32 mouse

Protein Ontology

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PROi
PR:Q811P8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000041444 Expressed in 230 organ(s), highest expression level in cingulate cortex
ExpressionAtlasiQ811P8 baseline and differential
GenevisibleiQ811P8 MM

Family and domain databases

CDDicd07298 PX_RICS, 1 hit
Gene3Di1.10.555.10, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR042139 PX_ARHGAP32
IPR036871 PX_dom_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00787 PX, 1 hit
PF00620 RhoGAP, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG32_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q811P8
Secondary accession number(s): B9EHJ8, Q6A010
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: October 16, 2019
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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