UniProtKB - Q811H0 (ZBT42_MOUSE)

BLAST

>sp|Q811H0|ZBT42_MOUSE Zinc finger and BTB domain-containing protein 42 OS=Mus musculus OX=10090 GN=Zbtb42 PE=1 SV=2
MEFPEHGVRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDQPASS
RDTVRLNGDIVTVPAFSRLLDFMYEGRLDLHNLPVEDVLAAASYLHMYDIVKVCKGRLRK
KDPDLETRTLGTELPGQPPHPLPSWSPAFCQAAPKAKHPSLGVKATHPLPTFGPPSWQVA
EQSSGALDLSLKPSPRPEQVHPPCRLQTSLCSSVQQVAQPLVKAEQDSFSEQDSSSPQSA
DRSPPPVCASAAQGLAVDLEPLHIEGTGSQQLGLPAEPVLDSEELGPSRHLCICPLCCKL
FPSTHALQLHLSAHFRERDSVRARLSPEGSVPTCPLCSKTFSCTYTLKRHERTHSGEKPY
TCVQCGKSFQYSHNLSRHAVVHTREKPHACRWCERRFTQSGDLYRHVRKFHYGLVKPLLV

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History
Entry version 104 (07 Nov 2018)
Sequence version 2 (02 Mar 2010)
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Protein

Zinc finger and BTB domain-containing protein 42

Gene

Zbtb42

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	292 – 314	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	332 – 354	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	360 – 382	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	388 – 411	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to DNA damage stimulus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
muscle organ development Source: UniProtKB
negative regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 18262495

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger and BTB domain-containing protein 42 Alternative name(s): Protein simiRP58
Gene namesⁱ	Name:Zbtb42
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:3644133 Zbtb42

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000391930	1 – 420	Zinc finger and BTB domain-containing protein 42Add BLAST		420

Proteomic databases

PaxDbⁱ	Q811H0
PRIDEⁱ	Q811H0

PTM databases

PhosphoSitePlusⁱ	Q811H0

PhosphoSitePlusⁱ

Q811H0

Expressionⁱ

Tissue specificityⁱ

Highly expressed in skeletal muscle and ovary (at protein level). Low expression in brain, lung, spleen, liver and heart (at protein level). Not detected in kidney and intestines (at protein level). Also observed in testis and, at lower levels, in stomach and nervous system.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000037638 Expressed in 164 organ(s), highest expression level in stomach
ExpressionAtlasⁱ	Q811H0 baseline and differential
Genevisibleⁱ	Q811H0 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000133152

STRINGⁱ

10090.ENSMUSP00000133152

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q811H0
SMRⁱ	Q811H0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	24 – 92	BTBPROSITE-ProRule annotationAdd BLAST		69

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB18 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	292 – 314	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	332 – 354	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	360 – 382	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	388 – 411	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150831
InParanoidⁱ	Q811H0
OMAⁱ	YEGRMEF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A78
PhylomeDBⁱ	Q811H0
TreeFamⁱ	TF337437

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q811H0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEFPEHGVRL LGRLRQQREL GFLCDCTVLV GDARFPAHRA VLAACSVYFH 
        60         70         80         90        100
LFYRDQPASS RDTVRLNGDI VTVPAFSRLL DFMYEGRLDL HNLPVEDVLA 
       110        120        130        140        150
AASYLHMYDI VKVCKGRLRK KDPDLETRTL GTELPGQPPH PLPSWSPAFC 
       160        170        180        190        200
QAAPKAKHPS LGVKATHPLP TFGPPSWQVA EQSSGALDLS LKPSPRPEQV 
       210        220        230        240        250
HPPCRLQTSL CSSVQQVAQP LVKAEQDSFS EQDSSSPQSA DRSPPPVCAS 
       260        270        280        290        300
AAQGLAVDLE PLHIEGTGSQ QLGLPAEPVL DSEELGPSRH LCICPLCCKL 
       310        320        330        340        350
FPSTHALQLH LSAHFRERDS VRARLSPEGS VPTCPLCSKT FSCTYTLKRH 
       360        370        380        390        400
ERTHSGEKPY TCVQCGKSFQ YSHNLSRHAV VHTREKPHAC RWCERRFTQS 
       410        420
GDLYRHVRKF HYGLVKPLLV

Length:420

Mass (Da):46,717

Last modified:March 2, 2010 - v2

Checksum:ⁱ885237984257BBC7

Isoform 2 (identifier: Q811H0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-178: MEFPEHGVRL...LPTFGPPSWQ → MTSSRSARADSERRTQIWRP

« Hide

        10         20         30         40         50
MTSSRSARAD SERRTQIWRP VAEQSSGALD LSLKPSPRPE QVHPPCRLQT 
        60         70         80         90        100
SLCSSVQQVA QPLVKAEQDS FSEQDSSSPQ SADRSPPPVC ASAAQGLAVD 
       110        120        130        140        150
LEPLHIEGTG SQQLGLPAEP VLDSEELGPS RHLCICPLCC KLFPSTHALQ 
       160        170        180        190        200
LHLSAHFRER DSVRARLSPE GSVPTCPLCS KTFSCTYTLK RHERTHSGEK 
       210        220        230        240        250
PYTCVQCGKS FQYSHNLSRH AVVHTREKPH ACRWCERRFT QSGDLYRHVR 
       260 
KFHYGLVKPL LV

Note: No experimental confirmation available.

Show »

Length:262

Mass (Da):29,169

Checksum:ⁱFDBB573271FD1A78

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3UYC4	G3UYC4_MOUSE	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing protein 42	Zbtb42	60	Annotation score:
G3UY89	G3UY89_MOUSE	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing protein 42	Zbtb42	110	Annotation score:

Sequence cautionⁱ

The sequence AAH46387 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	197	P → R in AAH46387 (PubMed:15489334).Curated	1
Sequence conflictⁱ	254	G → S in AAH46387 (PubMed:15489334).Curated	1
Sequence conflictⁱ	330	S → T in AAH46387 (PubMed:15489334).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_038770	1 – 178	MEFPE…PPSWQ → MTSSRSARADSERRTQIWRP in isoform 2. 1 PublicationAdd BLAST		178

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC124373 Genomic DNA No translation available. BC046387 mRNA Translation: AAH46387.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS49190.1 [Q811H0-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001093930.1, NM_001100460.1 [Q811H0-1]
UniGeneⁱ	Mm.11350

Genome annotation databases

Ensemblⁱ	ENSMUST00000169593; ENSMUSP00000133152; ENSMUSG00000037638 [Q811H0-1]
GeneIDⁱ	382639
KEGGⁱ	mmu:382639
UCSC genome browser More...UCSCⁱ	uc007pez.2 mouse [Q811H0-2] uc007pfa.2 mouse [Q811H0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q811H0	Zinc finger and BTB domain-containing protein 42 (Fragment)		MOUSE		110	UniRef100_Q811H0
UPI0003D74FB3		MOUSE		338

Protein	Similar proteins		Species	Score	Length	Source
Q811H0	Zinc finger and BTB domain-containing protein 42		RAT		420	UniRef90_Q811H0
Zinc finger and BTB domain-containing protein 42 (Fragment)		MOUSE		110
Uncharacterized protein		NEOLE		435
zinc finger and BTB domain-containing protein 42		MESAU		420
UPI00042AB8D9		PERMB		420
+8

Protein	Similar proteins		Species	Score	Length	Source
Q811H0	Zinc finger and BTB domain-containing protein 42		RAT		420	UniRef50_Q811H0
Zinc finger and BTB domain-containing protein 42 (Fragment)		MOUSE		110
Uncharacterized protein		NEOLE		435
zinc finger and BTB domain-containing protein 42		MESAU		420
Zinc finger and BTB domain-containing protein 42 (Fragment)		TUPCH		352
+15
Q811H0-2	Uncharacterized protein		SHEEP		296	UniRef50_Q811H0-2
zinc finger and BTB domain-containing protein 42		LEPWE		244

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC124373 Genomic DNA No translation available. BC046387 mRNA Translation: AAH46387.1 Different initiation.
CCDSⁱ	CCDS49190.1 [Q811H0-1]
RefSeqⁱ	NP_001093930.1, NM_001100460.1 [Q811H0-1]
UniGeneⁱ	Mm.11350

3D structure databases

ProteinModelPortalⁱ	Q811H0
SMRⁱ	Q811H0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000133152

STRINGⁱ

10090.ENSMUSP00000133152

PTM databases

PhosphoSitePlusⁱ	Q811H0

PhosphoSitePlusⁱ

Q811H0

Proteomic databases

PaxDbⁱ	Q811H0
PRIDEⁱ	Q811H0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000169593; ENSMUSP00000133152; ENSMUSG00000037638 [Q811H0-1]
GeneIDⁱ	382639
KEGGⁱ	mmu:382639
UCSCⁱ	uc007pez.2 mouse [Q811H0-2] uc007pfa.2 mouse [Q811H0-1]

Organism-specific databases

CTDⁱ	100128927
MGIⁱ	MGI:3644133 Zbtb42

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00930000150831
InParanoidⁱ	Q811H0
OMAⁱ	YEGRMEF
OrthoDBⁱ	EOG091G0A78
PhylomeDBⁱ	Q811H0
TreeFamⁱ	TF337437

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q811H0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000037638 Expressed in 164 organ(s), highest expression level in stomach
ExpressionAtlasⁱ	Q811H0 baseline and differential
Genevisibleⁱ	Q811H0 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZBT42_MOUSE
Accessionⁱ	Q811H0Primary (citable) accession number: Q811H0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 2, 2010
	Last sequence update:	March 2, 2010
	Last modified:	November 7, 2018
	This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q811H0 (ZBT42_MOUSE)

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Zinc finger and BTB domain-containing protein 42

Zbtb42

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ