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UniProtKB - Q811H0 (ZBT42_MOUSE)
Protein
Zinc finger and BTB domain-containing protein 42
Gene
Zbtb42
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 292 – 314 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 332 – 354 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 360 – 382 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 388 – 411 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- muscle organ development Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and BTB domain-containing protein 42Alternative name(s): Protein simiRP58 |
Gene namesi | Name:Zbtb42 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3644133, Zbtb42 |
VEuPathDBi | HostDB:ENSMUSG00000037638 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- nucleoplasm 1 Publication
Note: In skeletal myofibers, highly enriched in subsynaptic nuclei at the neuromuscular junctions.1 Publication
Nucleus
- nucleoplasm Source: UniProtKB
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000391930 | 1 – 420 | Zinc finger and BTB domain-containing protein 42Add BLAST | 420 |
Proteomic databases
PaxDbi | Q811H0 |
PRIDEi | Q811H0 |
ProteomicsDBi | 275127 [Q811H0-1] 275128 [Q811H0-2] |
PTM databases
PhosphoSitePlusi | Q811H0 |
Expressioni
Tissue specificityi
Highly expressed in skeletal muscle and ovary (at protein level). Low expression in brain, lung, spleen, liver and heart (at protein level). Not detected in kidney and intestines (at protein level). Also observed in testis and, at lower levels, in stomach and nervous system.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000037638, Expressed in dorsal pancreas and 191 other tissues |
ExpressionAtlasi | Q811H0, baseline and differential |
Genevisiblei | Q811H0, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000133152 |
Miscellaneous databases
RNActi | Q811H0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 92 | BTBPROSITE-ProRule annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 127 – 204 | DisorderedSequence analysisAdd BLAST | 78 | |
Regioni | 222 – 247 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 222 – 243 | Polar residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 292 – 314 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 332 – 354 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 360 – 382 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 388 – 411 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163959 |
HOGENOMi | CLU_034521_0_0_1 |
InParanoidi | Q811H0 |
OMAi | PCILQTP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q811H0 |
TreeFami | TF337437 |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q811H0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEFPEHGVRL LGRLRQQREL GFLCDCTVLV GDARFPAHRA VLAACSVYFH
60 70 80 90 100
LFYRDQPASS RDTVRLNGDI VTVPAFSRLL DFMYEGRLDL HNLPVEDVLA
110 120 130 140 150
AASYLHMYDI VKVCKGRLRK KDPDLETRTL GTELPGQPPH PLPSWSPAFC
160 170 180 190 200
QAAPKAKHPS LGVKATHPLP TFGPPSWQVA EQSSGALDLS LKPSPRPEQV
210 220 230 240 250
HPPCRLQTSL CSSVQQVAQP LVKAEQDSFS EQDSSSPQSA DRSPPPVCAS
260 270 280 290 300
AAQGLAVDLE PLHIEGTGSQ QLGLPAEPVL DSEELGPSRH LCICPLCCKL
310 320 330 340 350
FPSTHALQLH LSAHFRERDS VRARLSPEGS VPTCPLCSKT FSCTYTLKRH
360 370 380 390 400
ERTHSGEKPY TCVQCGKSFQ YSHNLSRHAV VHTREKPHAC RWCERRFTQS
410 420
GDLYRHVRKF HYGLVKPLLV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3UY89 | G3UY89_MOUSE | Zinc finger and BTB domain-containi... | Zbtb42 | 110 | Annotation score: | ||
G3UYC4 | G3UYC4_MOUSE | Zinc finger and BTB domain-containi... | Zbtb42 | 60 | Annotation score: |
Sequence cautioni
The sequence AAH46387 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 197 | P → R in AAH46387 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 254 | G → S in AAH46387 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 330 | S → T in AAH46387 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038770 | 1 – 178 | MEFPE…PPSWQ → MTSSRSARADSERRTQIWRP in isoform 2. 1 PublicationAdd BLAST | 178 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC124373 Genomic DNA No translation available. BC046387 mRNA Translation: AAH46387.1 Different initiation. |
CCDSi | CCDS49190.1 [Q811H0-1] |
RefSeqi | NP_001093930.1, NM_001100460.1 [Q811H0-1] |
Genome annotation databases
Ensembli | ENSMUST00000169593; ENSMUSP00000133152; ENSMUSG00000037638 [Q811H0-1] |
GeneIDi | 382639 |
KEGGi | mmu:382639 |
UCSCi | uc007pez.2, mouse [Q811H0-2] uc007pfa.2, mouse [Q811H0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC124373 Genomic DNA No translation available. BC046387 mRNA Translation: AAH46387.1 Different initiation. |
CCDSi | CCDS49190.1 [Q811H0-1] |
RefSeqi | NP_001093930.1, NM_001100460.1 [Q811H0-1] |
3D structure databases
SMRi | Q811H0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000133152 |
PTM databases
PhosphoSitePlusi | Q811H0 |
Proteomic databases
PaxDbi | Q811H0 |
PRIDEi | Q811H0 |
ProteomicsDBi | 275127 [Q811H0-1] 275128 [Q811H0-2] |
Protocols and materials databases
Antibodypediai | 58775, 72 antibodies from 11 providers |
Genome annotation databases
Ensembli | ENSMUST00000169593; ENSMUSP00000133152; ENSMUSG00000037638 [Q811H0-1] |
GeneIDi | 382639 |
KEGGi | mmu:382639 |
UCSCi | uc007pez.2, mouse [Q811H0-2] uc007pfa.2, mouse [Q811H0-1] |
Organism-specific databases
CTDi | 100128927 |
MGIi | MGI:3644133, Zbtb42 |
VEuPathDBi | HostDB:ENSMUSG00000037638 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163959 |
HOGENOMi | CLU_034521_0_0_1 |
InParanoidi | Q811H0 |
OMAi | PCILQTP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q811H0 |
TreeFami | TF337437 |
Miscellaneous databases
BioGRID-ORCSi | 382639, 4 hits in 65 CRISPR screens |
ChiTaRSi | Zbtb42, mouse |
PROi | PR:Q811H0 |
RNActi | Q811H0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037638, Expressed in dorsal pancreas and 191 other tissues |
ExpressionAtlasi | Q811H0, baseline and differential |
Genevisiblei | Q811H0, MM |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZBT42_MOUSE | |
Accessioni | Q811H0Primary (citable) accession number: Q811H0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 2, 2010 |
Last sequence update: | March 2, 2010 | |
Last modified: | February 23, 2022 | |
This is version 118 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families