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Protein

Zinc finger and BTB domain-containing protein 42

Gene

Zbtb42

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri292 – 314C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 411C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: GO_Central
  • muscle organ development Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 42
Alternative name(s):
Protein simiRP58
Gene namesi
Name:Zbtb42
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:3644133 Zbtb42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003919301 – 420Zinc finger and BTB domain-containing protein 42Add BLAST420

Proteomic databases

PaxDbiQ811H0
PRIDEiQ811H0

PTM databases

PhosphoSitePlusiQ811H0

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle and ovary (at protein level). Low expression in brain, lung, spleen, liver and heart (at protein level). Not detected in kidney and intestines (at protein level). Also observed in testis and, at lower levels, in stomach and nervous system.2 Publications

Gene expression databases

BgeeiENSMUSG00000037638 Expressed in 164 organ(s), highest expression level in stomach
ExpressionAtlasiQ811H0 baseline and differential
GenevisibleiQ811H0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000133152

Structurei

3D structure databases

ProteinModelPortaliQ811H0
SMRiQ811H0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 92BTBPROSITE-ProRule annotationAdd BLAST69

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri292 – 314C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 411C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150831
InParanoidiQ811H0
OMAiYEGRMEF
OrthoDBiEOG091G0A78
PhylomeDBiQ811H0
TreeFamiTF337437

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q811H0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEFPEHGVRL LGRLRQQREL GFLCDCTVLV GDARFPAHRA VLAACSVYFH
60 70 80 90 100
LFYRDQPASS RDTVRLNGDI VTVPAFSRLL DFMYEGRLDL HNLPVEDVLA
110 120 130 140 150
AASYLHMYDI VKVCKGRLRK KDPDLETRTL GTELPGQPPH PLPSWSPAFC
160 170 180 190 200
QAAPKAKHPS LGVKATHPLP TFGPPSWQVA EQSSGALDLS LKPSPRPEQV
210 220 230 240 250
HPPCRLQTSL CSSVQQVAQP LVKAEQDSFS EQDSSSPQSA DRSPPPVCAS
260 270 280 290 300
AAQGLAVDLE PLHIEGTGSQ QLGLPAEPVL DSEELGPSRH LCICPLCCKL
310 320 330 340 350
FPSTHALQLH LSAHFRERDS VRARLSPEGS VPTCPLCSKT FSCTYTLKRH
360 370 380 390 400
ERTHSGEKPY TCVQCGKSFQ YSHNLSRHAV VHTREKPHAC RWCERRFTQS
410 420
GDLYRHVRKF HYGLVKPLLV
Length:420
Mass (Da):46,717
Last modified:March 2, 2010 - v2
Checksum:i885237984257BBC7
GO
Isoform 2 (identifier: Q811H0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: MEFPEHGVRL...LPTFGPPSWQ → MTSSRSARADSERRTQIWRP

Note: No experimental confirmation available.
Show »
Length:262
Mass (Da):29,169
Checksum:iFDBB573271FD1A78
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UYC4G3UYC4_MOUSE
Zinc finger and BTB domain-containi...
Zbtb42
60Annotation score:
G3UY89G3UY89_MOUSE
Zinc finger and BTB domain-containi...
Zbtb42
110Annotation score:

Sequence cautioni

The sequence AAH46387 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197P → R in AAH46387 (PubMed:15489334).Curated1
Sequence conflicti254G → S in AAH46387 (PubMed:15489334).Curated1
Sequence conflicti330S → T in AAH46387 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0387701 – 178MEFPE…PPSWQ → MTSSRSARADSERRTQIWRP in isoform 2. 1 PublicationAdd BLAST178

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124373 Genomic DNA No translation available.
BC046387 mRNA Translation: AAH46387.1 Different initiation.
CCDSiCCDS49190.1 [Q811H0-1]
RefSeqiNP_001093930.1, NM_001100460.1 [Q811H0-1]
UniGeneiMm.11350

Genome annotation databases

EnsembliENSMUST00000169593; ENSMUSP00000133152; ENSMUSG00000037638 [Q811H0-1]
GeneIDi382639
KEGGimmu:382639
UCSCiuc007pez.2 mouse [Q811H0-2]
uc007pfa.2 mouse [Q811H0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124373 Genomic DNA No translation available.
BC046387 mRNA Translation: AAH46387.1 Different initiation.
CCDSiCCDS49190.1 [Q811H0-1]
RefSeqiNP_001093930.1, NM_001100460.1 [Q811H0-1]
UniGeneiMm.11350

3D structure databases

ProteinModelPortaliQ811H0
SMRiQ811H0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000133152

PTM databases

PhosphoSitePlusiQ811H0

Proteomic databases

PaxDbiQ811H0
PRIDEiQ811H0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169593; ENSMUSP00000133152; ENSMUSG00000037638 [Q811H0-1]
GeneIDi382639
KEGGimmu:382639
UCSCiuc007pez.2 mouse [Q811H0-2]
uc007pfa.2 mouse [Q811H0-1]

Organism-specific databases

CTDi100128927
MGIiMGI:3644133 Zbtb42

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150831
InParanoidiQ811H0
OMAiYEGRMEF
OrthoDBiEOG091G0A78
PhylomeDBiQ811H0
TreeFamiTF337437

Miscellaneous databases

PROiPR:Q811H0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037638 Expressed in 164 organ(s), highest expression level in stomach
ExpressionAtlasiQ811H0 baseline and differential
GenevisibleiQ811H0 MM

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBT42_MOUSE
AccessioniPrimary (citable) accession number: Q811H0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: March 2, 2010
Last modified: November 7, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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