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Protein

Ankyrin repeat domain-containing protein 26

Gene

Ankrd26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior.2 Publications

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 26
Gene namesi
Name:Ankrd26
Synonyms:Kiaa1074
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1917887 Ankrd26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Deficient mice display hyperphagia, severe obesity, gigantism, insulin resistance and elevated serum leptin levels potentially linked to defects in primary cilia (PubMed:18162531, PubMed:24633808).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002408441 – 1581Ankyrin repeat domain-containing protein 26Add BLAST1581

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineBy similarity1
Modified residuei239PhosphoserineCombined sources1
Modified residuei260PhosphoserineBy similarity1
Modified residuei511PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ811D2
PaxDbiQ811D2
PRIDEiQ811D2

PTM databases

iPTMnetiQ811D2
PhosphoSitePlusiQ811D2

Expressioni

Tissue specificityi

Widely expressed (PubMed:18162531). Expressed in the arcuate and ventromedial nuclei within the hypothalamus and in the ependyma and the circumventricular organs (at protein level) (PubMed:18162531).2 Publications

Gene expression databases

CleanExiMM_ANKRD26

Interactioni

Subunit structurei

Interacts with TRIO. Interacts with GPS2. Interacts with CCDC85B. Interacts with HMMR.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108449

Structurei

3D structure databases

ProteinModelPortaliQ811D2
SMRiQ811D2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati46 – 76ANK 1Add BLAST31
Repeati80 – 109ANK 2Add BLAST30
Repeati113 – 142ANK 3Add BLAST30
Repeati146 – 175ANK 4Add BLAST30
Repeati179 – 208ANK 5Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili715 – 845Sequence analysisAdd BLAST131
Coiled coili876 – 1345Sequence analysisAdd BLAST470
Coiled coili1396 – 1470Sequence analysisAdd BLAST75
Coiled coili1521 – 1550Sequence analysisAdd BLAST30

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IHJ1 Eukaryota
COG0666 LUCA
HOGENOMiHOG000033957
HOVERGENiHBG079895
InParanoidiQ811D2
PhylomeDBiQ811D2

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039497 CC144C-like_CC_dom
IPR021885 DUF3496
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF14915 CCDC144C, 1 hit
PF12001 DUF3496, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q811D2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKIFGFRSK GPSPLGPSAR PRSNCVGFGR ESASGSHVPR YHIHDKDMGK
60 70 80 90 100
IHKAASVGDV AKVQHILILG KSGVNDRDKK DRTALHLACA YGHPEVVTLL
110 120 130 140 150
VERKCEIDAR DSESSTALIK AVQCQEEECA AILLDHGADP NVMDSSGNTA
160 170 180 190 200
LHYAVYSENT SMAAKLLAHN ANIEAKNKDD LTPMLLAVKE NKQHIVEFLV
210 220 230 240 250
KKKASIHAVD QLGSNRQMFE YDGKRLQRSE NSNPVDNGSE DGSLTRSYNT
260 270 280 290 300
PGPADSWPTS DEEDYNFDNK NVPKINLTEL WTAAQQSRKN QTKCGFEELD
310 320 330 340 350
NGARFDDSDS PSESEDAIEV EPAPSVRVQT LSPSRQSPDP VEGATELAIE
360 370 380 390 400
GEENGTDVIE SASQEQPNHD NLTRADGWHK SNKSEMMSAL GLGEDEDEDS
410 420 430 440 450
PWDSESISES VSLKDVGHFS GTADQTGKRR AHGQIEDVTY IPSCMSGSRN
460 470 480 490 500
FKMAKLEESR NVGLPVAHME APRKYVIMEP TIERRAPVLN KTETVGMTDA
510 520 530 540 550
QTFKSEPESV SREEQTRLSG SEDSQQKVEE KRKYKNNEAE PSGNLYSGAA
560 570 580 590 600
DGGADVKPQS GDTENQQSPR EGSEGRGSGP ALLMKEAKKM ENEKWVSREP
610 620 630 640 650
ARTAMSERTG LPTGGWPQMQ DGSCWSDTDQ SEARPTKKTS SKHNKDSGQT
660 670 680 690 700
AAVDNLDDFT ESSETASEDH ELQGPDSESI LCAIEHLRLE CKDTASLLKI
710 720 730 740 750
RDAVYSYKRL IELKRSHCEL LTGKLKRMEN KYKGLQKEMS ETEEVKSRLE
760 770 780 790 800
HEKVGWEQEL CRLRFALKQE EEKRRSADQL SEKTMEQLRR KGEQCQSEVE
810 820 830 840 850
ARQQLEASLR TLEMELKTVK SHLNQVLEER NETQRQLSRE QNARMLQDGI
860 870 880 890 900
LASHLCKQKE IEMTQKKMTS EVSVSHEKEK DLLHKNQRLQ DEVAVLRLEM
910 920 930 940 950
DTIKSHNQEK EKRYLEDIKI ANEKNDNLQR MVKLNMLSSK LDNEKQNKER
960 970 980 990 1000
LETDVESFRS RLASALHDHA EIQTAKRDLE IAFQRARDEW FRVKDKMNFD
1010 1020 1030 1040 1050
MSNLRDNNEV LSQQLSKTER KLNSLEIEFH HTKDELREKT LALKHAQRDL
1060 1070 1080 1090 1100
SQTQCQMKEV EHMFQDEQGK VSKFMGKQES IEERLAQLQS ENTLLRQQLD
1110 1120 1130 1140 1150
DAANKAESKD KTIVNIQDQF QDVLTRFQAE SQRHSLRLED RNQELVSECS
1160 1170 1180 1190 1200
HLRERLCQYE NEKAEREVVV RQLQQELADT LKKQSMSEAS LEVSSRYRSN
1210 1220 1230 1240 1250
LEEEARDLKK KLGQLRSQLQ EARDQHREAV HHAEKMEDHL QKLELEKSKF
1260 1270 1280 1290 1300
EITIKKQSEE IDQLQENLSR VNLSEEDKEK LQKLTELKES LECTVDQEQK
1310 1320 1330 1340 1350
RSSALEKELM RTIQKKCGKL EKNKKQLEQE VVNLRSHMEK NMVEHSQAQQ
1360 1370 1380 1390 1400
YAREVEERAR QDLVEKLKQV NLFLQAQAAS QESLEQLREN SNASVRSQME
1410 1420 1430 1440 1450
LRIKDLESQL YRMKAQEDFD KIELEKYKQL YQEEFRARKS LSSKLNKTSE
1460 1470 1480 1490 1500
KLEEASSKLL LEEQQNRSLL STLSTRPVVE CPCVGSLHNS LVFNRTLIPR
1510 1520 1530 1540 1550
ENIVVPTSGL QPSNKRVEIY LTKMHQELEK SINRELKEAT AELESEFCRV
1560 1570 1580
SPLGSATKAS QDQLSDASQE FIDILKKKYM I
Length:1,581
Mass (Da):180,647
Last modified:June 27, 2006 - v2
Checksum:i6C298F79B3731DC9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z482D3Z482_MOUSE
Ankyrin repeat domain-containing pr...
Ankrd26
1,681Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti469M → MGMEKN in BAB30930 (PubMed:16141072).Curated1
Sequence conflicti476V → A in BAB30930 (PubMed:16141072).Curated1
Sequence conflicti527K → R in BAB30930 (PubMed:16141072).Curated1
Sequence conflicti601A → V in AAH47067 (PubMed:15489334).Curated1
Sequence conflicti604A → T in AAH47067 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti114S → N1 Publication1
Natural varianti142V → A1 Publication1
Natural varianti218M → I1 Publication1
Natural varianti399D → H1 Publication1
Natural varianti450N → S1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047067 mRNA Translation: AAH47067.1 Sequence problems.
AK017783 mRNA Translation: BAB30930.1
AK173096 Transcribed RNA Translation: BAD32374.1
UniGeneiMm.276116

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC047067 mRNA Translation: AAH47067.1 Sequence problems.
AK017783 mRNA Translation: BAB30930.1
AK173096 Transcribed RNA Translation: BAD32374.1
UniGeneiMm.276116

3D structure databases

ProteinModelPortaliQ811D2
SMRiQ811D2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108449

PTM databases

iPTMnetiQ811D2
PhosphoSitePlusiQ811D2

Proteomic databases

MaxQBiQ811D2
PaxDbiQ811D2
PRIDEiQ811D2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1917887 Ankrd26
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IHJ1 Eukaryota
COG0666 LUCA
HOGENOMiHOG000033957
HOVERGENiHBG079895
InParanoidiQ811D2
PhylomeDBiQ811D2

Miscellaneous databases

PROiPR:Q811D2
SOURCEiSearch...

Gene expression databases

CleanExiMM_ANKRD26

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039497 CC144C-like_CC_dom
IPR021885 DUF3496
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF14915 CCDC144C, 1 hit
PF12001 DUF3496, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiANR26_MOUSE
AccessioniPrimary (citable) accession number: Q811D2
Secondary accession number(s): Q69ZS2, Q9CS61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: October 10, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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