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UniProtKB - Q811D2 (ANR26_MOUSE)
Protein
Ankyrin repeat domain-containing protein 26
Gene
Ankrd26
Organism
Mus musculus (Mouse)
Status
Functioni
Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior.
2 PublicationsGO - Biological processi
- glucose homeostasis Source: MGI
- negative regulation of ERK1 and ERK2 cascade Source: MGI
- negative regulation of fat cell differentiation Source: UniProtKB
- negative regulation of insulin receptor signaling pathway Source: MGI
- negative regulation of multicellular organism growth Source: MGI
- negative regulation of organ growth Source: MGI
- regulation of fatty acid metabolic process Source: MGI
- regulation of feeding behavior Source: MGI
- regulation of lipid metabolic process Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: Ankyrin repeat domain-containing protein 26 |
Gene namesi | Name:Ankrd26 Synonyms:Kiaa1074 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1917887, Ankrd26 |
Subcellular locationi
Cytoplasm and Cytosol
- cytosol 1 Publication
Note: Located just near the plasma membrane in close association with filamentous actin.1 Publication
Cytoskeleton
- actin cytoskeleton Source: MGI
- centrosome Source: MGI
Cytosol
- cytosol Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000240844 | 1 – 1581 | Ankyrin repeat domain-containing protein 26Add BLAST | 1581 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 13 | PhosphoserineBy similarity | 1 | |
Modified residuei | 239 | PhosphoserineCombined sources | 1 | |
Modified residuei | 260 | PhosphoserineBy similarity | 1 | |
Modified residuei | 511 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q811D2 |
PaxDbi | Q811D2 |
PRIDEi | Q811D2 |
ProteomicsDBi | 282119 |
PTM databases
iPTMneti | Q811D2 |
PhosphoSitePlusi | Q811D2 |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
Interacts with TRIO.
Interacts with GPS2.
Interacts with CCDC85B.
Interacts with HMMR.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000108449 |
Miscellaneous databases
RNActi | Q811D2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 46 – 76 | ANK 1Add BLAST | 31 | |
Repeati | 80 – 109 | ANK 2Add BLAST | 30 | |
Repeati | 113 – 142 | ANK 3Add BLAST | 30 | |
Repeati | 146 – 175 | ANK 4Add BLAST | 30 | |
Repeati | 179 – 208 | ANK 5Add BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 22 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 225 – 270 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 299 – 343 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 361 – 381 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 488 – 652 | DisorderedSequence analysisAdd BLAST | 165 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 715 – 845 | Sequence analysisAdd BLAST | 131 | |
Coiled coili | 876 – 1345 | Sequence analysisAdd BLAST | 470 | |
Coiled coili | 1396 – 1470 | Sequence analysisAdd BLAST | 75 | |
Coiled coili | 1521 – 1550 | Sequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 230 – 256 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 506 – 538 | Basic and acidic residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 559 – 573 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 586 – 601 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Keywords - Domaini
ANK repeat, Coiled coil, RepeatPhylogenomic databases
eggNOGi | ENOG502QR0R, Eukaryota |
InParanoidi | Q811D2 |
PhylomeDBi | Q811D2 |
Family and domain databases
Gene3Di | 1.25.40.20, 2 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR039497, CC144C-like_CC_dom IPR021885, DUF3496 |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF14915, CCDC144C, 2 hits PF12001, DUF3496, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q811D2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKIFGFRSK GPSPLGPSAR PRSNCVGFGR ESASGSHVPR YHIHDKDMGK
60 70 80 90 100
IHKAASVGDV AKVQHILILG KSGVNDRDKK DRTALHLACA YGHPEVVTLL
110 120 130 140 150
VERKCEIDAR DSESSTALIK AVQCQEEECA AILLDHGADP NVMDSSGNTA
160 170 180 190 200
LHYAVYSENT SMAAKLLAHN ANIEAKNKDD LTPMLLAVKE NKQHIVEFLV
210 220 230 240 250
KKKASIHAVD QLGSNRQMFE YDGKRLQRSE NSNPVDNGSE DGSLTRSYNT
260 270 280 290 300
PGPADSWPTS DEEDYNFDNK NVPKINLTEL WTAAQQSRKN QTKCGFEELD
310 320 330 340 350
NGARFDDSDS PSESEDAIEV EPAPSVRVQT LSPSRQSPDP VEGATELAIE
360 370 380 390 400
GEENGTDVIE SASQEQPNHD NLTRADGWHK SNKSEMMSAL GLGEDEDEDS
410 420 430 440 450
PWDSESISES VSLKDVGHFS GTADQTGKRR AHGQIEDVTY IPSCMSGSRN
460 470 480 490 500
FKMAKLEESR NVGLPVAHME APRKYVIMEP TIERRAPVLN KTETVGMTDA
510 520 530 540 550
QTFKSEPESV SREEQTRLSG SEDSQQKVEE KRKYKNNEAE PSGNLYSGAA
560 570 580 590 600
DGGADVKPQS GDTENQQSPR EGSEGRGSGP ALLMKEAKKM ENEKWVSREP
610 620 630 640 650
ARTAMSERTG LPTGGWPQMQ DGSCWSDTDQ SEARPTKKTS SKHNKDSGQT
660 670 680 690 700
AAVDNLDDFT ESSETASEDH ELQGPDSESI LCAIEHLRLE CKDTASLLKI
710 720 730 740 750
RDAVYSYKRL IELKRSHCEL LTGKLKRMEN KYKGLQKEMS ETEEVKSRLE
760 770 780 790 800
HEKVGWEQEL CRLRFALKQE EEKRRSADQL SEKTMEQLRR KGEQCQSEVE
810 820 830 840 850
ARQQLEASLR TLEMELKTVK SHLNQVLEER NETQRQLSRE QNARMLQDGI
860 870 880 890 900
LASHLCKQKE IEMTQKKMTS EVSVSHEKEK DLLHKNQRLQ DEVAVLRLEM
910 920 930 940 950
DTIKSHNQEK EKRYLEDIKI ANEKNDNLQR MVKLNMLSSK LDNEKQNKER
960 970 980 990 1000
LETDVESFRS RLASALHDHA EIQTAKRDLE IAFQRARDEW FRVKDKMNFD
1010 1020 1030 1040 1050
MSNLRDNNEV LSQQLSKTER KLNSLEIEFH HTKDELREKT LALKHAQRDL
1060 1070 1080 1090 1100
SQTQCQMKEV EHMFQDEQGK VSKFMGKQES IEERLAQLQS ENTLLRQQLD
1110 1120 1130 1140 1150
DAANKAESKD KTIVNIQDQF QDVLTRFQAE SQRHSLRLED RNQELVSECS
1160 1170 1180 1190 1200
HLRERLCQYE NEKAEREVVV RQLQQELADT LKKQSMSEAS LEVSSRYRSN
1210 1220 1230 1240 1250
LEEEARDLKK KLGQLRSQLQ EARDQHREAV HHAEKMEDHL QKLELEKSKF
1260 1270 1280 1290 1300
EITIKKQSEE IDQLQENLSR VNLSEEDKEK LQKLTELKES LECTVDQEQK
1310 1320 1330 1340 1350
RSSALEKELM RTIQKKCGKL EKNKKQLEQE VVNLRSHMEK NMVEHSQAQQ
1360 1370 1380 1390 1400
YAREVEERAR QDLVEKLKQV NLFLQAQAAS QESLEQLREN SNASVRSQME
1410 1420 1430 1440 1450
LRIKDLESQL YRMKAQEDFD KIELEKYKQL YQEEFRARKS LSSKLNKTSE
1460 1470 1480 1490 1500
KLEEASSKLL LEEQQNRSLL STLSTRPVVE CPCVGSLHNS LVFNRTLIPR
1510 1520 1530 1540 1550
ENIVVPTSGL QPSNKRVEIY LTKMHQELEK SINRELKEAT AELESEFCRV
1560 1570 1580
SPLGSATKAS QDQLSDASQE FIDILKKKYM I
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3Z482 | D3Z482_MOUSE | Ankyrin repeat domain-containing pr... | Ankrd26 | 1,681 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 469 | M → MGMEKN in BAB30930 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 476 | V → A in BAB30930 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 527 | K → R in BAB30930 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 601 | A → V in AAH47067 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 604 | A → T in AAH47067 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 114 | S → N1 Publication | 1 | |
Natural varianti | 142 | V → A1 Publication | 1 | |
Natural varianti | 218 | M → I1 Publication | 1 | |
Natural varianti | 399 | D → H1 Publication | 1 | |
Natural varianti | 450 | N → S1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC047067 mRNA Translation: AAH47067.1 Sequence problems. AK017783 mRNA Translation: BAB30930.1 AK173096 Transcribed RNA Translation: BAD32374.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC047067 mRNA Translation: AAH47067.1 Sequence problems. AK017783 mRNA Translation: BAB30930.1 AK173096 Transcribed RNA Translation: BAD32374.1 |
3D structure databases
AlphaFoldDBi | Q811D2 |
SMRi | Q811D2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000108449 |
PTM databases
iPTMneti | Q811D2 |
PhosphoSitePlusi | Q811D2 |
Proteomic databases
MaxQBi | Q811D2 |
PaxDbi | Q811D2 |
PRIDEi | Q811D2 |
ProteomicsDBi | 282119 |
Organism-specific databases
MGIi | MGI:1917887, Ankrd26 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | ENOG502QR0R, Eukaryota |
InParanoidi | Q811D2 |
PhylomeDBi | Q811D2 |
Miscellaneous databases
ChiTaRSi | Ankrd26, mouse |
PROi | PR:Q811D2 |
RNActi | Q811D2, protein |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 1.25.40.20, 2 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR039497, CC144C-like_CC_dom IPR021885, DUF3496 |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF14915, CCDC144C, 2 hits PF12001, DUF3496, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ANR26_MOUSE | |
Accessioni | Q811D2Primary (citable) accession number: Q811D2 Secondary accession number(s): Q69ZS2, Q9CS61 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | June 27, 2006 | |
Last modified: | May 25, 2022 | |
This is version 114 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot