Ankyrin repeat domain-containing protein 26

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• glucose homeostasis Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 21842266
• negative regulation of ERK1 and ERK2 cascade Source: MGIInferred from mutant phenotypeⁱ
  • 21669876
• negative regulation of fat cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • 22666460
• negative regulation of insulin receptor signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • 21842266
• negative regulation of multicellular organism growth Source: MGIInferred from mutant phenotypeⁱ
  • 18162531
• negative regulation of organ growth Source: MGIInferred from mutant phenotypeⁱ
  • 18162531
• regulation of fatty acid metabolic process Source: MGIInferred from mutant phenotypeⁱ
  • 18162531
• regulation of feeding behavior Source: MGIInferred from mutant phenotypeⁱ
  • 18162531
• regulation of lipid metabolic process Source: MGIInferred from mutant phenotypeⁱ
  • 18162531

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MKKIFGFRSK GPSPLGPSAR PRSNCVGFGR ESASGSHVPR YHIHDKDMGK 
        60         70         80         90        100
IHKAASVGDV AKVQHILILG KSGVNDRDKK DRTALHLACA YGHPEVVTLL 
       110        120        130        140        150
VERKCEIDAR DSESSTALIK AVQCQEEECA AILLDHGADP NVMDSSGNTA 
       160        170        180        190        200
LHYAVYSENT SMAAKLLAHN ANIEAKNKDD LTPMLLAVKE NKQHIVEFLV 
       210        220        230        240        250
KKKASIHAVD QLGSNRQMFE YDGKRLQRSE NSNPVDNGSE DGSLTRSYNT 
       260        270        280        290        300
PGPADSWPTS DEEDYNFDNK NVPKINLTEL WTAAQQSRKN QTKCGFEELD 
       310        320        330        340        350
NGARFDDSDS PSESEDAIEV EPAPSVRVQT LSPSRQSPDP VEGATELAIE 
       360        370        380        390        400
GEENGTDVIE SASQEQPNHD NLTRADGWHK SNKSEMMSAL GLGEDEDEDS 
       410        420        430        440        450
PWDSESISES VSLKDVGHFS GTADQTGKRR AHGQIEDVTY IPSCMSGSRN 
       460        470        480        490        500
FKMAKLEESR NVGLPVAHME APRKYVIMEP TIERRAPVLN KTETVGMTDA 
       510        520        530        540        550
QTFKSEPESV SREEQTRLSG SEDSQQKVEE KRKYKNNEAE PSGNLYSGAA 
       560        570        580        590        600
DGGADVKPQS GDTENQQSPR EGSEGRGSGP ALLMKEAKKM ENEKWVSREP 
       610        620        630        640        650
ARTAMSERTG LPTGGWPQMQ DGSCWSDTDQ SEARPTKKTS SKHNKDSGQT 
       660        670        680        690        700
AAVDNLDDFT ESSETASEDH ELQGPDSESI LCAIEHLRLE CKDTASLLKI 
       710        720        730        740        750
RDAVYSYKRL IELKRSHCEL LTGKLKRMEN KYKGLQKEMS ETEEVKSRLE 
       760        770        780        790        800
HEKVGWEQEL CRLRFALKQE EEKRRSADQL SEKTMEQLRR KGEQCQSEVE 
       810        820        830        840        850
ARQQLEASLR TLEMELKTVK SHLNQVLEER NETQRQLSRE QNARMLQDGI 
       860        870        880        890        900
LASHLCKQKE IEMTQKKMTS EVSVSHEKEK DLLHKNQRLQ DEVAVLRLEM 
       910        920        930        940        950
DTIKSHNQEK EKRYLEDIKI ANEKNDNLQR MVKLNMLSSK LDNEKQNKER 
       960        970        980        990       1000
LETDVESFRS RLASALHDHA EIQTAKRDLE IAFQRARDEW FRVKDKMNFD 
      1010       1020       1030       1040       1050
MSNLRDNNEV LSQQLSKTER KLNSLEIEFH HTKDELREKT LALKHAQRDL 
      1060       1070       1080       1090       1100
SQTQCQMKEV EHMFQDEQGK VSKFMGKQES IEERLAQLQS ENTLLRQQLD 
      1110       1120       1130       1140       1150
DAANKAESKD KTIVNIQDQF QDVLTRFQAE SQRHSLRLED RNQELVSECS 
      1160       1170       1180       1190       1200
HLRERLCQYE NEKAEREVVV RQLQQELADT LKKQSMSEAS LEVSSRYRSN 
      1210       1220       1230       1240       1250
LEEEARDLKK KLGQLRSQLQ EARDQHREAV HHAEKMEDHL QKLELEKSKF 
      1260       1270       1280       1290       1300
EITIKKQSEE IDQLQENLSR VNLSEEDKEK LQKLTELKES LECTVDQEQK 
      1310       1320       1330       1340       1350
RSSALEKELM RTIQKKCGKL EKNKKQLEQE VVNLRSHMEK NMVEHSQAQQ 
      1360       1370       1380       1390       1400
YAREVEERAR QDLVEKLKQV NLFLQAQAAS QESLEQLREN SNASVRSQME 
      1410       1420       1430       1440       1450
LRIKDLESQL YRMKAQEDFD KIELEKYKQL YQEEFRARKS LSSKLNKTSE 
      1460       1470       1480       1490       1500
KLEEASSKLL LEEQQNRSLL STLSTRPVVE CPCVGSLHNS LVFNRTLIPR 
      1510       1520       1530       1540       1550
ENIVVPTSGL QPSNKRVEIY LTKMHQELEK SINRELKEAT AELESEFCRV 
      1560       1570       1580 
SPLGSATKAS QDQLSDASQE FIDILKKKYM I                     

Experimental Info

Natural variant

Sequence databases

Keywords - Coding sequence diversityⁱ

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot