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Protein

U3 small nucleolar ribonucleoprotein protein MPP10

Gene

Mphosph10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein
Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar ribonucleoprotein protein MPP10
Alternative name(s):
M phase phosphoprotein 10
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915223 Mphosph10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001215361 – 681U3 small nucleolar ribonucleoprotein protein MPP10Add BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61PhosphoserineSequence analysis1
Modified residuei120PhosphoserineBy similarity1
Modified residuei140PhosphoserineBy similarity1
Modified residuei164PhosphoserineCombined sources1
Modified residuei168PhosphoserineCombined sources1
Modified residuei172PhosphoserineCombined sources1
Modified residuei244PhosphoserineCombined sources1
Modified residuei247PhosphoserineCombined sources1
Modified residuei277PhosphoserineBy similarity1
Modified residuei346PhosphoserineCombined sources1
Cross-linki351Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki383Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki395Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki556Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei609N6-acetyllysineBy similarity1
Cross-linki632Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki649Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Phosphorylated in M (mitotic) phase.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ810V0
MaxQBiQ810V0
PaxDbiQ810V0
PeptideAtlasiQ810V0
PRIDEiQ810V0

PTM databases

iPTMnetiQ810V0
PhosphoSitePlusiQ810V0

Expressioni

Gene expression databases

BgeeiENSMUSG00000030521 Expressed in 287 organ(s), highest expression level in primary oocyte
GenevisibleiQ810V0 MM

Interactioni

Subunit structurei

Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with IMP3 and IMP4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi212574, 1 interactor
STRINGi10090.ENSMUSP00000032735

Structurei

3D structure databases

ProteinModelPortaliQ810V0
SMRiQ810V0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili109 – 139Sequence analysisAdd BLAST31
Coiled coili349 – 383Sequence analysisAdd BLAST35
Coiled coili471 – 491Sequence analysisAdd BLAST21
Coiled coili575 – 604Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi292 – 298Poly-Glu7
Compositional biasi666 – 671Poly-Lys6

Sequence similaritiesi

Belongs to the MPP10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2600 Eukaryota
COG5384 LUCA
GeneTreeiENSGT00390000011359
HOGENOMiHOG000046317
HOVERGENiHBG052502
InParanoidiQ810V0
KOiK14559
OMAiCFLTIQD
OrthoDBiEOG091G09Q2
TreeFamiTF105794

Family and domain databases

InterProiView protein in InterPro
IPR012173 Mpp10
PANTHERiPTHR17039 PTHR17039, 1 hit
PfamiView protein in Pfam
PF04006 Mpp10, 1 hit
PIRSFiPIRSF017300 snoRNP_Mpp10, 1 hit

Sequencei

Sequence statusi: Complete.

Q810V0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPRVFRRQT LERCLREIRK ATNRPECFLT IQNGLASNFT SLTKVLYDFN
60 70 80 90 100
KVLENGRISG SPLQKLEINS FDDEQIWQQL ELQNEPVLQY FQNAVSETVE
110 120 130 140 150
DEDISLLPEC EDEECEEDAS EVEADNQENL ETDLDEEQLS DEGGDVPKGR
160 170 180 190 200
DRAKSSRKSD PRKSPVFSDE DSDLDFDIGK LEQQTKMQIK PPGKPREKSV
210 220 230 240 250
VDDKFFKLSE MESFLEKVEK EEEKRPDGEE EDEEDIDLFE DIDSDESEGG
260 270 280 290 300
LFGRQKIKSN KSSRNLKYKD FFDPVESDED ITGVDEELGP DEEKEEEEGF
310 320 330 340 350
AEEADESISD TDEDNDLEED ENSDQHKGSL KRVTFALPDD EAEDTSPLAV
360 370 380 390 400
KQESDEVKSS FEKRQEKMNE KIASLEKELL DKKPWQLQGE VTAQKRPENS
410 420 430 440 450
LLEETLHFDH AVRMAPVITE ETTLHLEDII KQRIRDQAWD DVERKEKPKE
460 470 480 490 500
DAYEYKKRLT LDHEKSKLSL AEIYEQEYLK LNQQKTEEED NPEHVEIQKM
510 520 530 540 550
MDSLFLKLDA LSNFHFIPKP PVPEIKVVSN LPAITMEEVA PVSVSDAALL
560 570 580 590 600
APEEIKEKNK AGDLKTAAEK TATDKKRERR KKKYQKRLKI KEKEKRKKLL
610 620 630 640 650
EKNNPDQSKS SRAAASEKLK QLTKTGKVSL LKDERKDKPL KSSQAFFSKL
660 670 680
QDQVKMQIND AKQPEKIKKK KQDISVHKLK L
Length:681
Mass (Da):78,735
Last modified:July 27, 2011 - v2
Checksum:i2C4038ACA05F8ED2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99V → I in AAH49270 (PubMed:15489334).Curated1
Sequence conflicti135D → E in AAH49270 (PubMed:15489334).Curated1
Sequence conflicti329S → G in AAH49270 (PubMed:15489334).Curated1
Sequence conflicti487E → A in AAH49270 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129199 Genomic DNA No translation available.
BC049270 mRNA Translation: AAH49270.1
CCDSiCCDS21333.1
RefSeqiNP_080759.2, NM_026483.2
UniGeneiMm.26973

Genome annotation databases

EnsembliENSMUST00000032735; ENSMUSP00000032735; ENSMUSG00000030521
GeneIDi67973
KEGGimmu:67973
UCSCiuc009hgg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129199 Genomic DNA No translation available.
BC049270 mRNA Translation: AAH49270.1
CCDSiCCDS21333.1
RefSeqiNP_080759.2, NM_026483.2
UniGeneiMm.26973

3D structure databases

ProteinModelPortaliQ810V0
SMRiQ810V0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212574, 1 interactor
STRINGi10090.ENSMUSP00000032735

PTM databases

iPTMnetiQ810V0
PhosphoSitePlusiQ810V0

Proteomic databases

EPDiQ810V0
MaxQBiQ810V0
PaxDbiQ810V0
PeptideAtlasiQ810V0
PRIDEiQ810V0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032735; ENSMUSP00000032735; ENSMUSG00000030521
GeneIDi67973
KEGGimmu:67973
UCSCiuc009hgg.1 mouse

Organism-specific databases

CTDi10199
MGIiMGI:1915223 Mphosph10

Phylogenomic databases

eggNOGiKOG2600 Eukaryota
COG5384 LUCA
GeneTreeiENSGT00390000011359
HOGENOMiHOG000046317
HOVERGENiHBG052502
InParanoidiQ810V0
KOiK14559
OMAiCFLTIQD
OrthoDBiEOG091G09Q2
TreeFamiTF105794

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

PROiPR:Q810V0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030521 Expressed in 287 organ(s), highest expression level in primary oocyte
GenevisibleiQ810V0 MM

Family and domain databases

InterProiView protein in InterPro
IPR012173 Mpp10
PANTHERiPTHR17039 PTHR17039, 1 hit
PfamiView protein in Pfam
PF04006 Mpp10, 1 hit
PIRSFiPIRSF017300 snoRNP_Mpp10, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMPP10_MOUSE
AccessioniPrimary (citable) accession number: Q810V0
Secondary accession number(s): E9QM78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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